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Peripheral Nerve Injuries Treatment: a Systematic Review

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Abstract

Patients with peripheral nerve injuries, especially severe injury, often face poor nerve regeneration and incompletely functional recovery, even after surgical nerve repair. Current researches have extensively focused on the new approaches for the treatment of peripheral nerve injuries. This review summarizes treatments of peripheral nerve injures, from conventional suturing method, to conduit coaptation with stem cell and growth factor, and review the developments of research and clinical application of these therapies.

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References

  1. Jensen, P. H., Li, J. Y., Dahlström, A., & Dotti, C. G. (1999). Axonal transport of synucleins is mediated by all rate components. European Journal of Neuroscience, 11(10), 3369–3376.

    Article  CAS  PubMed  Google Scholar 

  2. Lundborg, G., & Richard, P. (2003). Bunge memorial lecture. Nerve injury and repair—a challenge to the plastic brain. Journal of the Peripheral Nervous System, 8(4), 209–226.

    Article  PubMed  Google Scholar 

  3. Johnson, E. O., & Soucacos, P. N. (2008). Nerve repair: experimental and clinical evaluation of biodegradable artificial nerve guides. Injury, 39(S3), 30–36.

    Article  Google Scholar 

  4. Sameem, M., Wood, T. J., & Bain, J. R. (2011). A systematic review on the use of fibrin glue for peripheral nerve repair. Plastic and Reconstructive Surgery, 127(6), 2381–2390.

    Article  CAS  PubMed  Google Scholar 

  5. Jiang, X., Lim, S. H., Mao, H.-Q., & Chew, S. Y. (2010). Current applications and future perspectives of artificial nerve conduits. Experimental Neurology, 223(1), 86–101.

    Article  PubMed  Google Scholar 

  6. Gu, X., Ding, F., Yang, Y., & Liu, J. (2011). Construction of tissue engineered nerve grafts and their application in peripheral nerve regeneration. Progress in Neurobiology, 93(2), 204–230.

    Article  CAS  PubMed  Google Scholar 

  7. Nichols, C. M., Brenner, M. J., Fox, I. K., Tung, T. H., Hunter, D. A., Rickman, S. R., et al. (2004). Effects of motor versus sensory nerve grafts on peripheral nerve regeneration. Experimental Neurology, 190(2), 347–355.

    Article  PubMed  Google Scholar 

  8. Panseri, S., Cunha, C., Lowery, J., Del Carro, U., Taraballi, F., Amadio, S., et al. (2008). Electrospun micro- and nanofiber tubes for functional nervous regeneration in sciatic nerve transections. BMC Biotechnology, 8, 39.

    Article  PubMed Central  PubMed  Google Scholar 

  9. Muir, D. (2010). The potentiation of peripheral nerve sheaths in regeneration and repair. Experimental Neurology, 223(1), 102–111.

    Article  CAS  PubMed  Google Scholar 

  10. Mackinnon, S. E., Doolabh, V. B., Novak, C. B., & Trulock, E. P. (2001). Clinical outcome following nerve allograft transplantation. Plastic and Reconstructive Surgery, 107(6), 1419–1429.

    Article  CAS  PubMed  Google Scholar 

  11. Whitlock, E. L., Tuffaha, S. H., Luciano, J. P., Yan, Y., Hunter, D. A., Magill, C. K., et al. (2009). Processed allografts and type I collagen conduits for repair of peripheral nerve gaps. Muscle and Nerve, 39(6), 787–799.

    Article  CAS  PubMed  Google Scholar 

  12. Zhang, Y., Luo, H., Zhang, Z., Lu, Y., Huang, X., Yang, L., et al. (2010). A nerve graft constructed with xenogeneic acellular nerve matrix and autologous adipose-derived mesenchymal stem cells. Biomaterials, 31(20), 5312–5324.

    Article  CAS  PubMed  Google Scholar 

  13. Lundborg, G., & Kanje, M. (1996). Bioartificial nerve grafts: a prototype. Scandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery, 30(2), 105–110.

    Article  CAS  PubMed  Google Scholar 

  14. Nadim, W., Anderson, P. N., & Turmaine, M. (1990). The role of Schwann cells and basal lamina tubes in the regeneration of axons through lengths of freeze-killed nerve grafts. Neuropathology and Applied Neurobiology, 16(5), 411–421.

    Article  CAS  PubMed  Google Scholar 

  15. Udina, E., Ceballos, D., Gold, B. G., & Navarro, X. (2003). FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers. Experimental Neurology, 183(1), 220–231.

    Article  CAS  PubMed  Google Scholar 

  16. Evans, D. G., Baser, M. E., McGaughran, J., Sharif, S., Howard, E., & Moran, A. (2002). Malignant peripheral nerve sheath tumours in neurofibromatosis 1. Journal of Medical Genetics, 39(5), 311–314.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  17. Schmidt, C. E., & Leach, J. B. (2003). Neural tissue engineering: strategies for repair and regeneration. Annual Review of Biomedical Engineering, 5, 293–347.

    Article  CAS  PubMed  Google Scholar 

  18. Pierucci, A., de Duek, E. A., & de Oliveira, A. L. (2008). Peripheral nerve regeneration through biodegradable conduits prepared using solvent evaporation. Tissue Engineering Part A, 14(5), 595–606.

    Article  CAS  PubMed  Google Scholar 

  19. Archibald, S. J., Shefner, J., Krarup, C., & Madison, R. D. (1995). Monkey median nerve repaired by nerve graft or collagen nerve guide tube. Journal of Neuroscience, 15(5pt2), 4109–4123.

    CAS  PubMed  Google Scholar 

  20. Kehoe, S., Zhang, X. F., & Boyd, D. (2012). FDA approved guidance conduits and wraps for peripheral nerve injury: a review of materials and efficacy. Injury, 43(5), 553–572.

    Article  CAS  PubMed  Google Scholar 

  21. Guénard, V., Kleitman, N., Morrissey, T. K., Bunge, R. P., & Aebischer, P. (1992). Syngeneic Schwann cells derived from adult nerves seeded in semipermeable guidance channels enhance peripheral nerve regeneration. Journal of Neuroscience, 12(9), 3310–3320.

    PubMed  Google Scholar 

  22. Mosahebi, A., Fuller, P., Wiberg, M., & Terenghi, G. (2002). Effect of allogeneic Schwann cell transplantation on peripheral nerve regeneration. Experimental Neurology, 173(2), 213–223.

    Article  CAS  PubMed  Google Scholar 

  23. Tohill, M., Mantovani, C., Wiberg, M., & Terenghi, G. (2004). Rat bone marrow mesenchymal stem cells glial markers and stimulate nerve regeneration. Neuroscience Letters, 362(3), 200–203.

    Article  CAS  PubMed  Google Scholar 

  24. Radtke, C., Aizer, A. A., Agulian, S. K., Lankford, K. L., Vogt, P. M., & Kocsis, J. D. (2009). Transplantation of olfactory ensheathing cells enhances peripheral nerve regeneration after microsurgical nerve repair. Brain Research, 13(1254), 10–17.

    Article  Google Scholar 

  25. Verdú, E., Navarro, X., Gudiño-Cabrera, G., Rodríguez, F. J., Ceballos, D., Valero, A., et al. (1999). Olfactory bulb ensheathing cells enhance peripheral nerve regeneration. Neuroreport, 10(5), 1097–1101.

    Article  PubMed  Google Scholar 

  26. Radtke, C., Wewetzer, K., Reimers, K., & Vogt, P. M. (2011). Transplantation of olfactory ensheathing cells as adjunct cell therapy for peripheral nerve injury. Cell Transplantation, 20(2), 145–152.

    Article  PubMed  Google Scholar 

  27. Tohill, M., & Terenghi, G. (2004). Stem-cell plasticity and therapy for injuries of the peripheral nervous system. Biotechnology and Applied Biochemistry, 40(Pt1), 17–24.

    CAS  PubMed  Google Scholar 

  28. Wang, Y., Zhao, Z., Ren, Z., Zhao, B., Zhang, L., Chen, J., et al. (2012). Recellularized nerve allografts with differentiated mesenchymal stem cell promote peripheral nerve regeneration. Neuroscience Letters, 514(1), 96–101.

    Article  CAS  PubMed  Google Scholar 

  29. Hu, N., Wu, H., Xue, C., Gong, Y., Wu, J., Xiao, Z., et al. (2013). Long-term outcome of the repair of 50 mm long median nerve defects in rhesus monkeys with marrow mesenchymal stem cells-containing, chitosan-based tissue engineered nerve grafts. Biomaterials, 34(1), 100–111.

    Article  CAS  PubMed  Google Scholar 

  30. Longo, F. M., Manthorpe, M., Skaper, S. D., Lundborg, G., & Varon, S. (1983). Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Research, 261(1), 109–116.

    Article  CAS  PubMed  Google Scholar 

  31. Kingham, P. J., Kalbermatten, D. F., Mahay, D., Armstrong, S. J., Wiberg, M., & Terenghi, G. (2007). Adipose-derived stem cells differentiate into a Schwann cell phenotype and promote neurite outgrowth in vitro. Experimental Neurology, 207(2), 267–274.

    Article  CAS  PubMed  Google Scholar 

  32. Tobita, M., Uysal, A. C., Ogawa, R., Hyakusoku, H., & Mizuno, H. (2008). Periodontal tissue regeneration with adipose-derived stem cells. Tissue Engineering Part A, 14(6), 945–953.

    Article  CAS  PubMed  Google Scholar 

  33. di Summa, P. G., Kingham, P. J., Raffoul, W., Wiberg, M., Terenghi, G., & Kalbermatten, D. F. (2010). Adipose-derived stem cells enhance peripheral nerve regeneration. Journal of Plastic Reconstructive and Aesthetic Surgery, 63(9), 1544–1552.

    Article  Google Scholar 

  34. Orbay, H., Uysal, A. C., Hyakusoku, H., & Mizuno, H. (2012). Differentiated and undifferentiated adipose-derived stem cells improve function in rats with peripheral nerve gaps. Journal of Plastic Reconstructive and Aesthetic Surgery, 65(5), 657–664.

    Article  Google Scholar 

  35. Rehman, J., Traktuev, D., Li, J., Merfeld-Clauss, S., Temm-Grove, C. J., Bovenkerk, J. E., et al. (2004). Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation, 109(10), 1292–1298.

    Article  PubMed  Google Scholar 

  36. Okada, Y., Matsumoto, A., Shimazaki, T., Enoki, R., Koizumi, A., Ishii, S., et al. (2008). Spatiotemporal recapitulation of central nervous system development by murine embryonic stem cell-derived neural stem/progenitor cells. Stem Cells, 26(12), 3086–3098.

    Article  CAS  PubMed  Google Scholar 

  37. Miura, K., Okada, Y., Aoi, T., Okada, A., Takahashi, K., Okita, K., et al. (2009). Variation in the safety of induced pluripotent stem cell lines. Nature Biotechnology, 27(8), 743–745.

    Article  CAS  PubMed  Google Scholar 

  38. Uemura, T., Takamatsu, K., Ikeda, M., Okada, M., Kazuki, K., Ikada, Y., et al. (2012). Transplantation of induced pluripotent stem cell-derived neurospheres for peripheral nerve repair. Biochemical and Biophysical Research Communications, 419(1), 130–135.

    Article  CAS  PubMed  Google Scholar 

  39. Xu, L., Zhou, S., Feng, G. Y., Zhang, L. P., Zhao, D. M., Sun, Y., et al. (2012). Neural stem cells enhance nerve regeneration after sciatic nerve injury in rats. Molecular Neurobiology, 46(2), 265–274.

    Article  CAS  PubMed  Google Scholar 

  40. Ohta, M., Suzuki, Y., Chou, H., Ishikawa, N., Suzuki, S., Tanihara, M., et al. (2004). Novel heparin/alginate gel combined with basic fibroblast growth factor promotes nerve regeneration in rat sciatic nerve. Journal of Biomedical Materials Research Part A, 71(4), 661–668.

    Article  PubMed  Google Scholar 

  41. Wang, S., Cai, Q., Hou, J., Bei, J., Zhang, T., Yang, J., et al. (2003). Acceleration effect of basic fibroblast growth factor on the regeneration of peripheral nerve through a 15-mm gap. Journal of Biomedical Materials Research Part A, 66(3), 522–531.

    Article  PubMed  Google Scholar 

  42. Li, Z., Peng, J., Wang, G., Yang, Q., Yu, H., Guo, Q., et al. (2008). Effects of local release of hepatocyte growth factor on peripheral nerve regeneration in acellular nerve grafts. Experimental Neurology, 214(1), 47–54.

    Article  CAS  PubMed  Google Scholar 

  43. Yu, H., Peng, J., Guo, Q., Zhang, L., Li, Z., Zhao, B., et al. (2009). Improvement of peripheral nerve regeneration in acellular nerve grafts with local release of nerve growth factor. Microsurgery, 29(4), 330–336.

    Article  PubMed  Google Scholar 

  44. Ikeda, M., Uemura, T., Takamatsu, K., Okada, M., Kazuki, K., Tabata, Y., Ikada, Y., Nakamura, H. (2013). Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stemcell technology and basic fibroblast growth factor drug delivery system. Journal of Biomedical Materials Research Part A (epub ahead of print).

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Authors and Affiliations

  1. Department of Hand Surgery, The First Hospital of Jilin University, Changchun, 130031, China

    Ruijun Li, Zhigang Liu, Yuemei Pan, Lei Chen, Zhixin Zhang & Laijin Lu

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  1. Ruijun Li
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Correspondence to Laijin Lu.

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Li, R., Liu, Z., Pan, Y. et al. Peripheral Nerve Injuries Treatment: a Systematic Review. Cell Biochem Biophys 68, 449–454 (2014). https://doi.org/10.1007/s12013-013-9742-1

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