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Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models

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Abstract

Diabetic cardiomyopathy, as one of the main cardiac complications in diabetic patients, is identified to connect with oxidative stress that is due to interruption in balance between reactive oxygen species or/and reactive nitrogen species generation and their clearance by antioxidant protection systems. Transcription factor the nuclear factor erythroid 2-related factor 2 (Nrf2) plays a significant role in maintaining the oxidative homeostasis by regulating multiple downstream antioxidants. The Nrf2 plays a significant role in ARE-mediated basal and inducible expression of more than 200 genes that can be grouped into numerous categories as well as antioxidant genes and phase II detoxifying enzymes. On the other hand, activation of Nrf2 by natural and synthetic therapeutics or antioxidants has been revealed effective for the prevention and treatment of toxicities and diseases connected with oxidative stress. Hence, recently focus has been shifted toward plants and plant-based medicines in curing such chronic diseases, as they are supposed to be less toxic. In this review, we focused on the role of some natural products on diabetic cardiomyopathy through Nrf2 pathway.

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Abbreviations

Nrf2:

Nuclear factor erythroid 2-related factor 2

Keap1:

Kelch-like ECH-associated protein 1

PI3K/AKT:

Phosphatidylinositol-3-kinase/protein kinase B

H2S:

Hydrogen sulfide

NQO1:

NAD(P)H:quinone oxidoreductase 1

HO-1:

Heme oxygenase 1

GCLM:

Glutamate–cysteine ligase modifier subunit

ERK/p38:

Extracellular signal-regulated kinases/p38

TBHP:

tert-Butyl hydroperoxide

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Acknowledgements

The authors thank for the management of K.S. Rangasamy College of Arts and Science (Autonomous) and Department of Science and Technology (DST-SERB) for providing financial support for this work (Ref No: SR/SO/HS/0227/2012).

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Author notes

  1. V. V. Sathibabu Uddandrao and Parim Brahmanaidu have contributed equally to this work.

Authors and Affiliations

  1. Department of Biochemistry, Centre for Biological Sciences, K. S. Rangasamy College of Arts and Science (Autonomous), Thokkavadi, Tiruchengode, Namakkal District, Tamilnadu, 637215, India

    V. V. Sathibabu Uddandrao, P. R. Nivedha, S. Vadivukkarasi & Ganapathy Saravanan

  2. Department of Biotechnology, Vikrama Simhapuri University, Nellore, Andhra Pradesh, 524003, India

    Parim Brahmanaidu

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  1. V. V. Sathibabu Uddandrao
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Correspondence to Ganapathy Saravanan.

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Sathibabu Uddandrao, V.V., Brahmanaidu, P., Nivedha, P.R. et al. Beneficial Role of Some Natural Products to Attenuate the Diabetic Cardiomyopathy Through Nrf2 Pathway in Cell Culture and Animal Models. Cardiovasc Toxicol 18, 199–205 (2018). https://doi.org/10.1007/s12012-017-9430-2

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