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Determination of Serum Zinc and Phosphorus Levels in Patients with Hypothyroidism

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Abstract  

Various studies reported that serum zinc (Zn) and phosphorus (P) levels altered in patients with hypothyroidism and vice versa, but results were found inconsistent. It was aimed to find the association between serum Zn and P in patients with hypothyroidism. In this case–control study, a total of 100 subjects (50 newly diagnosed patients of hypothyroidism and 50 controls) were enrolled aged between 25 and 60 years. Biochemical parameters such as thyroid profile, serum Zn, and P were estimated in each subject. A p < 0.05 was considered statistically significant. The mean level of body mass index (BMI), thyroid-stimulating hormone (TSH), and serum P was found significantly elevated in cases compared to controls (p < 0.001). However, the mean level of total triiodothyronine (T3), thyroxine (T4), and serum Zn was found significantly reduced in cases compared to controls (p < 0.001). The serum Zn has shown a significant negative correlation with T3 and BMI among cases (r =  − 0.313 p < 0.05, r =  − 0.338 p < 0.05, respectively). However, serum P has shown a significant positive correlation with TSH and BMI among cases (r = 0.310 p < 0.05, r = 0.449 p < 0.01, respectively). Regression analysis indicated that serum Zn significantly predicted hypothyroidism (p < 0.00). Similarly, serum P significantly predicted hypothyroidism (p < 0.007). Results showed that serum Zn levels were significantly reduced and serum P levels were significantly elevated in cases compared to controls. The serum Zn and serum P both significantly associated with hypothyroidism.

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Data Availability

The data that support the findings of this study are not openly available due to reasons of sensitivity and are available from the corresponding author upon reasonable request.

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Acknowledgements

We are grateful to the Prof. (Dr.) Abha Chandra, Dean, Integral Institute of Medical Sciences & Research (IIMSR) for the invaluable help and encouragement to carry out research work without any hindrance.

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Authors and Affiliations

  1. Department of Biochemistry, Integral Institute of Medical Sciences & Research (IIMSR), Integral University, Lucknow, Uttar Pradesh, 226026, India

    Amrendra Mani Patel, Saba Khan & Roshan Alam

  2. Department of Physiotherapy, Integral Institute of Allied Health Sciences & Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh, 226026, India

    Ahmad Merajul Hasan Inam

  3. Department of Basic Medical Sciences, Integral Institute of Allied Health Sciences & Research (IIAHSR), Integral University, Lucknow, Uttar Pradesh, 226026, India

    Mohammad Mustufa Khan

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"A.B. wrote the main manuscript text and C.D.E. prepared figures and tables. All authors reviewed the manuscript."

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Correspondence to Mohammad Mustufa Khan.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (IEC Approval No. IEC/IIMS&R/2022/15) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Patel, A.M., Khan, S., Inam, A.M.H. et al. Determination of Serum Zinc and Phosphorus Levels in Patients with Hypothyroidism. Biol Trace Elem Res (2023). https://doi.org/10.1007/s12011-023-03905-8

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