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Effect of Supranutritional Dosage Selenium in Neonatal Goat Kids on Productive Performance, Physicochemical Profiles in Meat, Selenium Levels in Tissues, and Histopathological Findings

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Abstract

Selenium (Se) is an essential element and antioxidant that catalyzes the destruction of hydrogen peroxide formed during cellular oxidative metabolism. Doses of Se as selenomethionine (SeMe) by oral route are 0.1–0.3 mgSe/kg DM, while the dose by parenteral route with sodium selenite (Na2SeO3) is 0.1 mgSe/BW. The effects of supranutritional Se supplementation on normal kids have rarely been studied. The objective of the study was to evaluate both Se sources on growth performance, Se in tissues, histopathological findings, and meat characteristics. Forty-five kids of the Pastoreña breed with 25-day age were distributed (4.7 ± 1.13 kg) in three treatments: a) control group, C: consumption with goat milk (GM: containing 0.135 mgSe/g); b) NaSe: GM plus Na2SeO3 injectable, 0.25 mgSe/kg BW; c) SeMe: GM plus oral dosage, 0.3 mgSe as SeMe daily. Fifteen animals per treatment were slaughtered at 7, 14, and 21 days. Feed conversion improved (P < 0.05) with Se supplement (P < 0.05) at 7 and 14 days. SeMe had higher protein and fat meat content (P < 0.05). SeMe increased Se liver at 14 and 21 days. NaSe and SeMe had higher (P < 0.05) levels of Se kidney. SeMe-21d showed 42% mononuclear and periportal cell infiltration lesions. In conclusion, Se administered through milk in goat kids was insufficient to prevent nutritional muscular dystrophy. The supranutritional dose of 0.25 mg/kg as NaSe was sufficient to maintain the Se level in tissues. SeMe increased Se liver and kidney efficiently. Both Se sources improved the bioavailability of the mineral in kids.

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Funding

This study was study was supported by the Colegio de Postgraduados Mexico and by the Scholarship of Consejo Nacional de Ciencia y Tecnología (CONACyT), México. The first author, Oscar Ortiz Morales (No. 283569), is a PhD student of the Program of Genetic Resources and Productivity–Livestock at the Graduate College (PREGEP-COLPOS).

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Authors and Affiliations

  1. Colegio de Postgraduados, Programa de Ganadería, Montecillo, Texcoco, México

    Oscar Ortiz-Morales, J. Efrén Ramírez-Bribiesca, David Hernández-Sánchez, José Ricardo Bárcena-Gama & José C. López-Ojeda

  2. Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma Benito Juárez de Oaxaca, Oaxaca de Juárez, México

    Jorge Hernández-Bautista

  3. FES-C, Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México, Mexico, México

    Elein Hernández-Trujillo, Victor M. Díaz-Sánchez & German Garrido-Fariña

  4. Colegio de Postgraduados, Programa de Genética, Montecillo, Texcoco, México

    Martha Hernández-Rodriguez

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All the authors have read and approved the submission of this manuscript. Ortiz-Morales, Ramírez-Bribiesca, Hernández-Bautista, and Díaz-Sánchez contributed to the study concept and design. Ortiz-Morales, Barcena-Gama, Diaz-Sánchez, and Garrido-Fariña reached the animals. Ortiz-Morales, Hernández-Rodriguez, Hernández-Trujillo, and López-Ojeda were responsible for the biochemical analysis. Ortiz-Morales and Hernández-Sánchez did the statistical analyses. Ortiz-Morales and Ramírez-Bribiesca drafted the manuscript and interpreted the data. Hernández-Bautista, Bárcena-Gama, Díaz-Sánchez, and Hernández-Sánchez contributed to the critical revisions of the manuscript for important intellectual content. All the authors provided study supervision.

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Correspondence to J. Efrén Ramírez-Bribiesca.

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Ortiz-Morales, O., Ramírez-Bribiesca, J.E., Hernández-Bautista, J. et al. Effect of Supranutritional Dosage Selenium in Neonatal Goat Kids on Productive Performance, Physicochemical Profiles in Meat, Selenium Levels in Tissues, and Histopathological Findings. Biol Trace Elem Res 201, 4374–4388 (2023). https://doi.org/10.1007/s12011-022-03528-5

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