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The Relation Between Trace Elements and Latent Tuberculosis Infection: a Study Based on National Health and Nutritional Examination Survey 2011–2012

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Abstract

This study aimed to analyze the potential association between trace elements and latent tuberculosis infection (LTBI) based on the data from the National Health and Nutritional Examination Survey (NHANES) during 2011–2012. In this cross-sectional study, tuberculin skin testing (TST) and QuantiFERON®-TB Gold In-Tube (QFT-GIT) were utilized to screen for LTBI. Participants with positive results of TST or/and QFT-GIT were defined as LTBI. Weighted univariate and multivariate logistic regression analyses were used to explore the association between trace elements and LTBI. Subgroup analyses were conducted according to gender, age, birthplace, race, and health insurance holding status. A total of 6064 participants were included in this study, of whom 655 (10.80%) participants were with positive results of LTBI. Weighted multivariable analysis demonstrated that zinc [odds ratio (OR) = 0.89; 95% confidence interval (CI), 0.82–0.97] and selenium (OR = 0.31; 95%CI, 0.13–0.70) in the serum may be associated with a reduced risk of LTBI. In different concentrations of zinc and selenium, serum zinc concentration of 12.56–13.99 μmol/l (vs. < 11.23 μmol/l; OR = 0.37, 95% CI, 0.20–0.67) was related to a reduced risk of LTBI, while no significant difference was observed under different selenium levels (P > 0.05). Subgroup analyses indicated that the role of zinc and selenium in reducing TB risk may be more significant in males, people aged 21–64, people born in the USA, people with health insurance, and non-Hispanic Whites. Maintaining serum zinc and selenium levels may help reduce the risk of LTBI and indirectly help people prevent TB.

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Data availability

The datasets generated during and/or analyzed during the current study are available in the NHANES database, https://www.cdc.gov/nchs/nhanes/index.htm.

References

  1. World Health Organization (2020) Global Tuberculosis Report 2020. Geneva. Available online: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2020. Accessed on 11 August 2021

  2. Simmons JD, Stein CM, Seshadri C et al (2018) Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection. Nat Rev Immunol 18(9):575–589. https://doi.org/10.1038/s41577-018-0025-3

    Article  CAS  Google Scholar 

  3. Cortese B, Micheli A, Picchi A et al (2010) Paclitaxel-coated balloon versus drug-eluting stent during PCI of small coronary vessels, a prospective randomised clinical trial. The PICCOLETO study. Heart 96(16):1291–1296. https://doi.org/10.1136/hrt.2010.195057

    Article  Google Scholar 

  4. Furin J, Cox H, Pai M (2019) Tuberculosis. Lancet 393(10181):1642–1656. https://doi.org/10.1016/S0140-6736(19)30308-3

    Article  Google Scholar 

  5. Estevez H, Palacios A, Gil D et al (2020) Antimycobacterial effect of selenium nanoparticles on mycobacterium tuberculosis. Front Microbiol 11:800. https://doi.org/10.3389/fmicb.2020.00800

    Article  Google Scholar 

  6. Gomez-Lara J, Ortega-Paz L, Brugaletta S et al (2020) Bioresorbable scaffolds versus permanent sirolimus-eluting stents in patients with ST-segment elevation myocardial infarction: vascular healing outcomes from the MAGSTEMI trial. EuroIntervention 16(11):e913–e921. https://doi.org/10.4244/EIJ-D-20-00198

    Article  Google Scholar 

  7. Heidary M, Zaker Bostanabad S, Amini SM et al (2019) The anti-mycobacterial activity of Ag, ZnO, And Ag- ZnO nanoparticles against MDR- and XDR-mycobacterium tuberculosis. Infect Drug Resist 12:3425–3435. https://doi.org/10.2147/IDR.S221408

    Article  CAS  Google Scholar 

  8. Neyrolles O, Mintz E, Catty P (2013) Zinc and copper toxicity in host defense against pathogens: mycobacterium tuberculosis as a model example of an emerging paradigm. Front Cell Infect Microbiol 3:89. https://doi.org/10.3389/fcimb.2013.00089

    Article  CAS  Google Scholar 

  9. Kurthkoti K, Amin H, Marakalala MJ, Ghanny S, Subbian S, Sakatos A, Livny J, Fortune SM, Berney M, Rodriguez GM (2017) The Capacity of Mycobacterium tuberculosis To Survive Iron Starvation Might Enable It To Persist in Iron-Deprived Microenvironments of Human Granulomas. mBio 8(4):e01092-17. https://doi.org/10.1128/mBio.01092-17

    Article  Google Scholar 

  10. Kolloli A, Singh P, Rodriguez GM, Subbian S (2019) Effect of iron supplementation on the outcome of non-progressive pulmonary mycobacterium tuberculosis infection. J Clin Med 8(8):1155. https://doi.org/10.3390/jcm8081155

    Article  CAS  Google Scholar 

  11. Neyrolles O, Wolschendorf F, Mitra A, Niederweis M (2015) Mycobacteria, metals, and the macrophage. Immunol Rev 264(1):249–263. https://doi.org/10.1111/imr.12265

    Article  CAS  Google Scholar 

  12. Choi R, Kim HT, Lim Y et al (2015) Serum Concentrations of Trace Elements in Patients with Tuberculosis and Its Association with Treatment Outcome. Nutrients 7(7):5969–5981. https://doi.org/10.3390/nu7075263

    Article  CAS  Google Scholar 

  13. Wang CY, Hu YL, Wang YH, Chen CH, Lai CC, Huang KL (2012) Association between vitamin D and latent tuberculosis infection in the United States: NHANES, 2011–2012. Infect Drug Resist 12:2251–2257. https://doi.org/10.2147/IDR.S213845

    Article  Google Scholar 

  14. Kinsara AJ, Niazi K, Patel I, Amoudi O (2003) Effectiveness of stents in small coronary arteries. Am J Cardiol 92(5):584–587. https://doi.org/10.1016/s0002-9149(03)00727-6

    Article  Google Scholar 

  15. National Health and Nutrition Examination Survey. 2011–2012 Data Documentation, Codebook, and Frequencies. Copper, Selenium & Zinc - Serum (CUSEZN_G). Available online: https://wwwn.cdc.gov/Nchs/Nhanes/2011-2012/CUSEZN_G.htm. Accessed on 11 August 2021

  16. Qian F, Misra S, Prabhu KS (2019) Selenium and selenoproteins in prostanoid metabolism and immunity. Crit Rev Biochem Mol Biol 54(6):484–516. https://doi.org/10.1080/10409238.2020.1717430

    Article  CAS  Google Scholar 

  17. Hood MI, Skaar EP (2012) Nutritional immunity: transition metals at the pathogen-host interface. Nat Rev Microbiol 10(8):525–537. https://doi.org/10.1038/nrmicro2836

    Article  CAS  Google Scholar 

  18. Gao S, Li T, Guo Y, Sun C, Xianyu B, Xu H (2020) Selenium-containing nanoparticles combine the NK cells mediated immunotherapy with radiotherapy and chemotherapy. Adv Mater 32(12):e1907568. https://doi.org/10.1002/adma.201907568

    Article  CAS  Google Scholar 

  19. Lai H, Zeng D, Liu C, Zhang Q, Wang X, Chen T (2019) Selenium-containing ruthenium complex synergizes with natural killer cells to enhance immunotherapy against prostate cancer via activating TRAIL/FasL signaling. Biomaterials 219:119377. https://doi.org/10.1016/j.biomaterials.2019.119377

    Article  CAS  Google Scholar 

  20. Ma C, Hoffmann FW, Marciel MP et al (2021) Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation. Mol Metab 47:101170. https://doi.org/10.1016/j.molmet.2021.101170

    Article  CAS  Google Scholar 

  21. Ma C, Hoffmann PR (2021) Selenoproteins as regulators of T cell proliferation, differentiation, and metabolism. Semin Cell Dev Biol 115:54–61. https://doi.org/10.1016/j.semcdb.2020.11.006

    Article  CAS  Google Scholar 

  22. Dow A, Sule P, O’Donnell TJ, Burger A, Mattila JT, Antonio B, Vergara K, Marcantonio E, Adams LG, James N, Williams PG, Cirillo JD, Prisic S (2021) Zinc limitation triggers anticipatory adaptations in Mycobacterium tuberculosis. PLoS Pathog 17(5):e1009570. https://doi.org/10.1371/journal.ppat.1009570

    Article  CAS  Google Scholar 

  23. Moraes ML, Ramalho DM, Delogo KN et al (2014) Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment. J Bras Pneumol 40(3):269–278. https://doi.org/10.1590/s1806-37132014000300010

    Article  Google Scholar 

  24. Moraes ML, Ramalho DM, Delogo KN et al (2014) Association of serum levels of iron, copper, and zinc, and inflammatory markers with bacteriological sputum conversion during tuberculosis treatment. Biol Trace Elem Res 160(2):176–184. https://doi.org/10.1007/s12011-014-0046-0

    Article  CAS  Google Scholar 

  25. Lönnroth K, Jaramillo E, Williams BG, Dye C, Raviglione M (2009) Drivers of tuberculosis epidemics: the role of risk factors and social determinants. Soc Sci Med 68(12):2240–2246. https://doi.org/10.1016/j.socscimed.2009.03.041

    Article  Google Scholar 

  26. de AlencarXimenes RA, de Fátima Pessoa Militão de Albuquerque M, Souza WV et al (2009) Is it better to be rich in a poor area or poor in a rich area? A multilevel analysis of a case-control study of social determinants of tuberculosis. Int J Epidemiol 38(5):1285-1296. https://doi.org/10.1093/ije/dyp224

    Article  Google Scholar 

  27. Kipp AM, Stout JE, Hamilton CD, Van Rie A (2008) Extrapulmonary tuberculosis, human immunodeficiency virus, and foreign birth in North Carolina, 1993–2006. BMC Public Health 8:107. https://doi.org/10.1186/1471-2458-8-107

    Article  Google Scholar 

  28. Talwar A, Li R, Langer AJ (2021) Association between Birth Region and Time to Tuberculosis Diagnosis among Non-US-Born Persons in the United States. Emerg Infect Dis 27(6):1645–1653. https://doi.org/10.3201/eid2706.203663

    Article  Google Scholar 

  29. Pedrazzoli D, Carter DJ, Borghi J, Laokri S, Boccia D, Houben RM (2021) Does Ghana’s National Health Insurance Scheme provide financial protection to tuberculosis patients and their households? Soc Sci Med 277:113875. https://doi.org/10.1016/j.socscimed.2021.113875

    Article  Google Scholar 

  30. Im C, Kim Y (2021) Spatial pattern of tuberculosis (TB) and related socio-environmental factors in South Korea, 2008–2016. PLoS ONE 6(8):e0255727. https://doi.org/10.1371/journal.pone.0255727

    Article  CAS  Google Scholar 

  31. Nahid P, Jarlsberg LG, Kato-Maeda M et al (2018) Interplay of strain and race/ethnicity in the innate immune response to M. tuberculosis. PLoS One 13(5):e0195392. https://doi.org/10.1371/journal.pone.0195392

    Article  CAS  Google Scholar 

  32. Noppert GA, Clarke P, Hicken MT, Wilson ML (2019) Understanding the intersection of race and place: the case of tuberculosis in Michigan. BMC Public Health 19(1):1669. https://doi.org/10.1186/s12889-019-8036-y

    Article  Google Scholar 

  33. Noppert GA, Wilson ML, Clarke P, Ye W, Davidson P, Yang Z (2017) Race and nativity are major determinants of tuberculosis in the U.S.: evidence of health disparities in tuberculosis incidence in Michigan, 2004–2012. BMC Public Health 17(1):538. https://doi.org/10.1186/s12889-017-4461-y

    Article  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Respiratory and Critical Care Medicine, Chifeng Municipal Hospital, Chifeng, 024000, People’s Republic of China

    Rui Zhao

  2. Department of Endocrinology, Chifeng Municipal Hospital, Chifeng, 024000, People’s Republic of China

    Wei Miao

  3. Department of Infectious Disease, Dingxi People’s Hospital, No. 22 Anding Road, Dingxi, 743000, People’s Republic of China

    Baohua Li

Authors
  1. Rui Zhao
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  2. Wei Miao
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  3. Baohua Li
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Wei Miao. The first draft of the manuscript was written by Rui Zhao and Baohua Li. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Baohua Li.

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This is an observational study. The Dingxi People’s Hospital Research Ethics Committee has confirmed that no ethical approval is required.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no competing interests.

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Zhao, R., Miao, W. & Li, B. The Relation Between Trace Elements and Latent Tuberculosis Infection: a Study Based on National Health and Nutritional Examination Survey 2011–2012. Biol Trace Elem Res 201, 1080–1089 (2023). https://doi.org/10.1007/s12011-022-03240-4

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  • DOI: https://doi.org/10.1007/s12011-022-03240-4

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