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Altered Serum Selenium and Uric Acid Levels and Dyslipidemia in Hemodialysis Patients Could be Associated with Enhanced Cardiovascular Risk

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Abstract

In the present study, the first objective was to follow up serum selenium (Se) concentrations in 117 hemodialysis patients (HPs) during a 2-year longitudinal study, relating concentrations to biochemical indexes (n = 6; namely lipoprotein profile, uric acid, and total protein levels). It was also evaluated whether the disease is associated with an enhanced cardiovascular risk. A healthy control group (n = 50) was also studied. Mean serum Se levels were significantly lower in HPs than in the controls (p = 0.002); mean levels significantly increased from the first to third blood sampling (p < 0.001). HPs showed a marked dyslipidemia, with a significant reduction in total cholesterol, low-density lipoprotein, and high-density lipoprotein cholesterol levels and a significant increase in triglyceride levels (p < 0.001). HPs showed a marked hyperuricemia (p < 0.001). Serum selenium levels in HPs were correlated negatively with uric acid levels (inflammation biomarker; p < 0.01). In HPs, serum Se levels are reduced due to their disease (chronic renal failure). Serum Se levels rose until the third blood sampling. The marked dyslipidemia and hyperuricemia found in HPs and the negative correlation between the serum Se and uric acid levels in these patients could imply an enhanced cardiovascular risk.

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Acknowledgments

The authors would like to thank all the volunteers for their participation. The study was supported by grant AGR-141 (Junta de Andalucía) Spain.

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Authors and Affiliations

  1. Department of Nutrition and Food Chemistry, Faculty of Pharmacy, University of Granada, 18071, Granada, Spain

    Loreto Martí del Moral, Miguel Navarro-Alarcón, Herminia López-Ga de la Serrana & María Jesús Oliveras-López

  2. Institute of Neurosciences, Department of Pharmacology, School of Medicine, University of Granada, 18071, Granada, Spain

    Ahmad Agil

  3. Hemodialysis Department, Guadix Hospital, Granada, Spain

    Magdalena Palomares-Bayo

Authors
  1. Loreto Martí del Moral
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  2. Ahmad Agil
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  3. Miguel Navarro-Alarcón
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  4. Herminia López-Ga de la Serrana
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  5. Magdalena Palomares-Bayo
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  6. María Jesús Oliveras-López
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Correspondence to Miguel Navarro-Alarcón.

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Martí del Moral, L., Agil, A., Navarro-Alarcón, M. et al. Altered Serum Selenium and Uric Acid Levels and Dyslipidemia in Hemodialysis Patients Could be Associated with Enhanced Cardiovascular Risk. Biol Trace Elem Res 144, 496–503 (2011). https://doi.org/10.1007/s12011-011-9152-4

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  • DOI: https://doi.org/10.1007/s12011-011-9152-4

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