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Ceruloplasmin, Copper, Selenium, Iron, Zinc, and Manganese Levels in Normal and Sulfite Oxidase Deficient Rat Plasma: Effects of Sulfite Exposure

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Abstract

A noticeable effect of sulfite treatment was observed on the plasma ceruloplasmin ferroxidase activity of rats with normal sulfite oxidase activity when compared to normal controls. The plasma levels of selenium, iron, and zinc were unaffected by sulfite in normal and sulfite oxidase (SOX)-deficient rats. While plasma level of Mn was decreasing, plasma Cu level increased in SOX-deficient rats. Treating SOX-deficient groups with sulfite did not alter plasma level of Mn but made plasma level of Cu back to its normal level. This is the first evidence that Cu and Mn status were affected in experimental sulfite oxidase deficiency induced by low molybdenum diet with tungsten addition deserving further research to determine the underlying mechanisms of these observations in experimental sulfite oxidase deficiency.

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Acknowledgments

The authors thank the Pamukkale University Research Fund, which supported this research through Project Number 2004-TPF006.

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Authors and Affiliations

  1. Faculty of Engineering, Food Engineering Department, Pamukkale University, Kinikli, 20020, Denizli, Turkey

    Emine Nur Herken

  2. Faculty of Medicine, Department of Histology and Embryology, Pamukkale University, Kinikli, 20020, Denizli, Turkey

    Erdogan Kocamaz

  3. Faculty of Medicine, Department of Physiology, Pamukkale University, Kinikli, 20020, Denizli, Turkey

    Melek Bor Kucukatay & Vural Kucukatay

  4. Faculty of Medicine, Department of Biochemistry, Suleyman Demirel University, Isparta, Turkey

    Huseyin Vural & Hilmi Demirin

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  1. Emine Nur Herken
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  2. Erdogan Kocamaz
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Correspondence to Emine Nur Herken.

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Herken, E.N., Kocamaz, E., Kucukatay, M.B. et al. Ceruloplasmin, Copper, Selenium, Iron, Zinc, and Manganese Levels in Normal and Sulfite Oxidase Deficient Rat Plasma: Effects of Sulfite Exposure. Biol Trace Elem Res 123, 202–210 (2008). https://doi.org/10.1007/s12011-008-8105-z

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  • DOI: https://doi.org/10.1007/s12011-008-8105-z

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