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Nano-delivery Systems and Therapeutic Applications of Phytodrug Mangiferin

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Abstract

In order to cure a range of ailments, scientists have investigated a number of bioactive antioxidant compounds produced from natural sources. Mangiferin, a C-glycosyl xanthone-structured yellow polyphenol, is abundant in mangoes and other dietary sources. In-depth examinations found that it is effective in the treatment of a variety of disorders due to its antiviral, anti-inflammatory, antiproliferative, antigenotoxic, antiatherogenic, radioprotective, nephroprotective, antihyperlipidemic, and antidiabetic properties. However, it is recognised that mangiferin’s poor bioavailability, volatility, and limited solubility restrict its therapeutic usefulness. Over time, effective solutions to these problems have arisen in the shape of effective delivery methods. The current articles present a summary of the several researches that have updated Mangiferin’s biopharmaceutical characteristics. Additionally, strategies for enhancing the bioavailability, stability, and solubility of this phytodrug have been discussed. This review provides detailed information on the development of innovative Mangiferin delivery methods such as nanoparticles, liposomes, micelles, niosomes, microspheres, metal nanoparticles, and complexation, as well as its therapeutic applications in a variety of sectors. This article provides effective guidance for researchers who desire to work on the formulation and development of an effective delivery method for improved magniferin therapeutic effectiveness.

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Authors and Affiliations

  1. Apollo College of Pharmacy, Anjora, Durg, 491001, Chhattisgarh, India

    Madhuri Baghel

  2. Foothill High School, 4375, Foothill Road, Pleasanton, CA, 94588, USA

    Ishita Baghel

  3. M. J. College, Bhilai, 490023, Chhattisgarh, India

    Pramila Kumari

  4. Bhupal Nobles’ Institute of Pharmaceutical Sciences, Bhupal Nobles’ University, Udaipur, 313001, India

    Meenakshi Bharkatiya

  5. Mahakal Institute of Pharmaceutical Studies, Ujjain, India

    Garvita Joshi

  6. Rungta College of Pharmaceutical Sciences and Research, Bhilai, 490023, CG, India

    Kalyani Sakure

  7. Shri Shankaracharya Institute of Pharmaceutical Sciences and Research, Junwani, Bhilai, 490020, Chhattisgarh, India

    Hemant Badwaik

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Baghel, M., Baghel, I., Kumari, P. et al. Nano-delivery Systems and Therapeutic Applications of Phytodrug Mangiferin. Appl Biochem Biotechnol (2024). https://doi.org/10.1007/s12010-024-04906-6

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