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Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats

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Abstract

Diabetes mellitus is a complex disorder that disturbs the metabolism of carbohydrates, fats, and proteins. Medicinal plants play an important role in the management of diabetes mellitus. The present study was aimed to evaluate the antidiabetic potential of Zaleya decandra roots on alloxan-induced diabetes in rats. Oral administration of ethanolic extract of the root (200 mg/kg body weight/day) for 15 days restored the levels of glucose, cholesterol, triglycerides, total proteins, urea, creatinine, lipid peroxidation level, and antioxidant enzymes significantly in diabetic rats. Histopathological studies showed significant changes like necrosis and degeneration in the liver and pancreas of alloxan-induced diabetic rats. Also these histopathological abnormalities were found to be normalized after treatment with Z. decandra extract. The efficacy of the root extract was found to be equivalent when compared to the standard hypoglycemic drug glibenclamide (1.25 mg/kg body weight/day, orally) in diabetic rats.

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References

  1. King, H., Aubert, R. E., & Herman, W. H. (1998). Diabetes Care, 21, 1414–1431.

    Article  CAS  Google Scholar 

  2. Boyle, J. P., Honneycutt, A. A., Narayan, K. M., Hoerger, T. J., Geiss, L. S., Chen, H., et al. (2001). Diabetes Care, 24, 1936–1940.

    Article  CAS  Google Scholar 

  3. Sy, G. Y., Cisse, A., Nongonierma, R. B., Sarr, M., Mbodj, N. A., & Faye, B. (2005). Journal of Ethnopharmacology, 98, 171–175.

    Article  CAS  Google Scholar 

  4. Zhang, B. B. & Moller, D. E. (2000). Current Opinion in Chemical Biology, 4, 461–467.

    Article  CAS  Google Scholar 

  5. Srinivasan, K. (2005). International Journal of Food Sciences and Nutrition, 56, 399–414.

    Article  CAS  Google Scholar 

  6. Nadkarni, A. N. (1989). Indian Materia Medica (Vol. 1). Mumbai: Popular Book Depot.

    Google Scholar 

  7. Warrier, P. K., Nambiar, V. P., & Ramankutty, C. (1994). Indian medicinal plants a compendium of 500 species. vol. 1 (pp. 349–351). India: Orient Longman Pvt Ltd.

    Google Scholar 

  8. Nadkarni, K. M. (1996). Indian Materia Medica. vol.1 (3rd ed., p. 1228). Mumbai: Popular Prakashan Pvt Ltd.

    Google Scholar 

  9. Singaravel Sengottuvelu, Duraisamy Srinivasan, Rasilingam Duraisami, Jothivel Nandhakumar, Mani Vasudevan, Thangavel Sivakumar (2008) International Journal of Green Pharmacy 122–125

  10. Balamurugan, G. & Muthusamy, P. (2008). Bangladesh Journal of Pharmacology, 3, 83–89.

    Google Scholar 

  11. Trease, G. S. & Evans, H. C. (1978). Textbook of pharmacognosy (9th ed.). London: Bailiar Zindall and Co.

    Google Scholar 

  12. Harborne, J. B. (1984). Phytochemical methods. London: Chapman and Hall.

    Google Scholar 

  13. Hogberg, J., Larson, R. E., Kristoferson, A., & Orrhenices, S. (1974). Biochemical and Biophysical Research Communications, 56, 836–842.

    Article  CAS  Google Scholar 

  14. Misra, H. P. & Fridovich, I. (1972). Journal of Biological Chemistry, 247, 3170–3175.

    CAS  Google Scholar 

  15. Lueck, H. (1965). In: Methods of Enzymatic Analysis. London: Academic.

    Google Scholar 

  16. Rotruck, J. T., Pope, A. L., & Ganther, H. S. (1973). Science, 179, 588–590.

    Article  CAS  Google Scholar 

  17. Pari, L. & Uma, M. L. (2000). Phytotherapy Research, 14, 136–138.

    Article  CAS  Google Scholar 

  18. Stanley, P., Prince, M., & Menon, V. P. (2000). Journal of Ethnopharmacology, 70, 9–15.

    Article  Google Scholar 

  19. Ivorra, M. D., Paya, M., & Villar, A. (1988). Planta Medica, 54, 282–286.

    Article  CAS  Google Scholar 

  20. Davis, S. N. & Granner, D. K. (1996). In L. S. Goodman & A. G. Gilman (Eds.), The pharmacological basis of therapeutics (6th ed.). New York: McMillan.

    Google Scholar 

  21. Andrew, J. K. (2000). Diabetes. New York: Churchill Living Stone. 1.

    Google Scholar 

  22. Surana, S. J., Gokhale, S. B., Jadhav, R. B., Sawant, R. L., & Jyoti, B. W. (2008). Indian Journal of Pharmaceutical Sciences, 70, 229.

    Google Scholar 

  23. Kaleem, M., Sheema, Sarmad, H., & Bano, B. (2005). Indian Journal of Physiology and Pharmacology, 49, 65.

    CAS  Google Scholar 

  24. Pushparaj, P. N., Low, H. K., Manikandan, J., Tan, B. K. H., & Tan, C. H. (2007). Journal of Ethnopharmacology, 111, 430.

    Article  CAS  Google Scholar 

  25. Murali, B., Upadhyaya, U. M., & Goyal, R. K. (2002). Journal of Ethnopharmacology, 81, 199.

    Article  CAS  Google Scholar 

  26. Alarcon, A. F. J., Calzada, B. F., Hernandez, G. E., Ruiz, A. C., & Roman, R. R. (2005). Journal of Ethnopharmacology, 97, 447.

    Article  Google Scholar 

  27. Kaleem, M., Asif, M., Ahmed, Q. U., & Bano, B. (2006). Singapore Medical Journal, 47, 670–675.

    CAS  Google Scholar 

  28. Mano, T., Shinohara, R., Nagasaka, A., Nakagawa, H., Uchimura, K., Hayashi, R., et al. (2000). Metabolism, 49, 427–431.

    Article  CAS  Google Scholar 

  29. Halliwall, B. & Gutteridge, J. M. C. (1989). Free radicals in biology and medicine (2nd ed.). Oxford: Clarendern.

    Google Scholar 

  30. Oberley, L. W. (1988). Free Radical Biology & Medicine, 5, 113.

    Article  CAS  Google Scholar 

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Acknowledgement

The authors would like to express thanks to Chairman and Chancellor, Chief Executive officer, Vice chancellor, and Registrar of Karpagam University, Coimbatore-21, India for providing laboratory facilities and constant encouragement.

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Authors and Affiliations

  1. Department of Biochemistry, Karpagam University, Coimbatore, India

    Periasamy Meenakshi, Rajendran Bhuvaneshwari, Muthaiyan Ahalliya Rathi, Lakshmanan Thirumoorthi, Dugganaboyana Chinna Guravaiah, Muthedath Janardhanan Jiji & Velliyur Kanniappan Gopalakrishnan

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  1. Periasamy Meenakshi
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  2. Rajendran Bhuvaneshwari
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  3. Muthaiyan Ahalliya Rathi
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Correspondence to Velliyur Kanniappan Gopalakrishnan.

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Meenakshi, P., Bhuvaneshwari, R., Rathi, M.A. et al. Antidiabetic Activity of Ethanolic Extract of Zaleya decandra in Alloxan-Induced Diabetic Rats. Appl Biochem Biotechnol 162, 1153–1159 (2010). https://doi.org/10.1007/s12010-009-8871-x

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