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Disease Mechanisms in psoriasis and psoriatic arthritis

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Abstract

Any hypothesis that tries to explain disease mechanisms in psoriasis and psoriatic arthritis (PsA) must take into account the containment of the inflammatory process to three specific sites: the skin, synovium, and enthesis. This article reviews the recent literature that advances our understanding of disease mechanisms at these specific sites. Additional progress will be achieved by research that focuses on common pathogenic pathways at these sites, in particular when searching for foreign candidates or autoantigens triggering the T-cell-mediated immune response.

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  1. Department of Rheumatology, St. Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

    Oliver FitzGerald MD, FRCPI, FRCP(UK)

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  1. Patrick Costello PhD
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  2. Oliver FitzGerald MD, FRCPI, FRCP(UK)
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Costello, P., FitzGerald, O. Disease Mechanisms in psoriasis and psoriatic arthritis. Curr Rheumatol Rep 3, 419–427 (2001). https://doi.org/10.1007/s11926-996-0013-7

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