Abstract
Nonculture methods are useful when diagnosing several systemic or invasive mycoses. Commercially available methods include immunoassays to detect cell wall or capsular polysaccharides; zymogen-based colorimetric assays to detect (1→3)-β-D-glucan, another cell wall polysaccharide; and molecular methods to detect fungal DNA. Molecular diagnostic methods have received much attention in the last decade but their accuracy has not been established, in part because of a lack of standardized, commercially available reagents or test kits. Serologic tests for antibodies are useful for diagnosis of histoplasmosis and coccidioidomycosis.
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Wheat, L.J. Nonculture diagnostic methods for invasive fungal infections. Curr Infect Dis Rep 9, 465–471 (2007). https://doi.org/10.1007/s11908-007-0071-7
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DOI: https://doi.org/10.1007/s11908-007-0071-7