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Beta-Blockers in Pregnancy: Clinical Update

  • Preeclampsia (VD Garovic, Section Editor)
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Abstract

Purpose of Review

The aim of this review was to determine the anticipated benefits and adverse effects of beta-blockers in pregnant women with hypertension. The other issue was to assess the possible adverse effects of beta-blockers for their babies and provide current consensus recommendations for appropriate selection and individualized antihypertensive treatment with beta-blockers in pregnancy-associated hypertension.

Recent Findings

Hypertensive disorders of pregnancy are a major cause of maternal and fetal morbidity, with consequences later in life. Certain beta-blockers are useful for ameliorating hypertension in pregnancy and may have a protective role in endothelial dysfunction. However, some aspects of beta-blocker use in pregnancy are contentious among providers. Evidence on their safety, although well documented, is variable, and recent research reveals areas of controversy. Besides intrauterine growth restriction, other neonatal and obstetric complications remain a concern and should be explored thoroughly.

Summary

Attention is necessary when treating pregnancy-associated hypertensive disorders with beta-blockers. Specific beta-blockers are considered safe in pregnancy, although the associated effects in the fetus are not clearly known and evidence is lacking for many safety outcomes, other than intrauterine growth restriction. Nevertheless, beta-blockers with specific indications in pregnancy under individualized selection and monitoring may confer substantial improvements in pregnant women with hypertension.

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Authors and Affiliations

  1. Department of Cardiology, School of Medicine, Hippokration General Hospital, National and Kapodistrian University of Athens, Athens, Greece

    Vasiliki Katsi & Konstantinos Tsioufis

  2. Department of Internal Medicine, Evangelismos General Hospital, Athens, Greece

    Ilias P. Papakonstantinou

  3. Departmentof Cardiology, General and Maternal Hospital of Athens Elena Venizelou, Athens, Greece

    Ourania Papazachou & Thomas Makris

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Katsi, V., Papakonstantinou, I.P., Papazachou, O. et al. Beta-Blockers in Pregnancy: Clinical Update. Curr Hypertens Rep 25, 13–24 (2023). https://doi.org/10.1007/s11906-023-01234-8

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