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Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease

  • Mechanisms of Hypertension and Target-Organ Damage (JE Hall and ME Hall, Section Editors)
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Abstract

Purpose of Review

The study aims to review recent advances in knowledge on the interplay between miRNAs and the sex-determining Region Y (SRY)-related high-mobility-group box 6 (Sox6) in physiology and pathophysiology, highlighting an important role in autoimmune and cardiometabolic conditions.

Recent Findings

The transcription factor Sox6 is an important member of the SoxD family and plays an indispensable role in adult tissue homeostasis, regeneration, and physiology. Abnormal expression of the Sox6 gene has been implicated in several disease conditions including diabetes, cardiomyopathy, autoimmune diseases, and hypertension. Expression of Sox6 is regulated by miRNAs, which are RNAs of about 22 nucleotides, and have also been implicated in several pathophysiological conditions where Sox6 plays a role.

Summary

Regulation of Sox6 by miRNAs is important in diverse physiological tissues and organs. Dysregulation of the interplay between miRNAs and Sox6 is an important determinant of various disease conditions and may be actionable for therapeutic purposes.

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Acknowledgements

Graphics were produced using Biorender.com.

Funding

This work was supported by National Institutes of Health grants K01HL130497, R03HL155041, and R01HL144941 to AK.

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Authors and Affiliations

  1. Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Room 536 Robinson Research Building, Nashville, TN, 37232-6602, USA

    Mohammad Saleem, Fernando Elijovich, Cheryl L. Laffer, Lale A. Ertuglu & Annet Kirabo

  2. Centre for Translational and Clinical Research, Jamia Hamdard, New Delhi, India

    Sharla Rahman

  3. School of Medicine and Health Sciences, Mulungushi University, HAND Research Group, Livingstone, Zambia

    Sepiso K. Masenga

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Contributions

M.S. and S.R. wrote the initial draft of the manuscript. F.E. and C.L.L edited the manuscript and figures. L.A.E. and and S.K.M. prepared the figures, edited, and improved the manuscript. A.K. edited and approved the final version.

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Correspondence to Annet Kirabo.

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Authors declare that they do not have any conflict of interest/competing interests except Dr. Annet Kirabo. Dr. Kirabo has a patent entitled “Methods for Treating Inflammation and Hypertension with Gamma-Ketoaldehyde Scavengers (U.S. Patent # 14/232,615). Dr. Kirabo is an associate editor for circulation research with compensation.

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Saleem, M., Rahman, S., Elijovich, F. et al. Sox6, A Potential Target for MicroRNAs in Cardiometabolic Disease. Curr Hypertens Rep 24, 145–156 (2022). https://doi.org/10.1007/s11906-022-01175-8

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