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Relevance of microRNA 21 in Different Types of Hypertension

  • Resistant Hypertension (E Pimenta, Section Editor)
  • Published:
Current Hypertension Reports Aims and scope Submit manuscript

Abstract

Hypertension (HTN) is a chronic medical condition that commonly affects the aging population worldwide. The prevalence of HTN is increasing in developing countries and is one of the leading causes of death in older individuals. HTN results from a complex interplay of genetic and environmental factors. Besides, HTN can result in various other health complications such as stroke and chronic kidney diseases, if not treated. Although various studies have explained the underlying mechanisms in the pathogenesis of HTN, limited information is available on their biomarkers. MicroRNAs (miRNAs) are RNA molecules that have been recognized as key regulators for HTN. miR-21 is a common microRNA that is has been reported to be significantly upregulated in HTN individuals. Hence, miR-21 can be a potential therapeutic target for HTN. The number of studies related to miR-21 on hypertension is limited. Therefore, the main thrust of this paper is to provide an overview of the current clinical evidence and significance of miR-21 in HTN.

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Acknowledgments

We would like to express our sincere gratitude to our Chancellor Dr.P.Shamaraju, REVA university, Bangalore for giving moral support and motivation.

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Authors and Affiliations

  1. Department of Biotechnology, School of Chemical and Biological Sciences, REVA University, Bangalore, 560064, India

    Durairaj Sekar, B. R. Shilpa & Anupam J. Das

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  1. Durairaj Sekar
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  2. B. R. Shilpa
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Correspondence to Durairaj Sekar.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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This article is part of the Topical Collection on Resistant Hypertension

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Sekar, D., Shilpa, B.R. & Das, A.J. Relevance of microRNA 21 in Different Types of Hypertension. Curr Hypertens Rep 19, 57 (2017). https://doi.org/10.1007/s11906-017-0752-z

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