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How Does Preeclampsia Predispose to Future Cardiovascular Disease?

  • Preeclampsia (VD Garovic, Section Editor)
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Abstract

Over the last few decades, there has been increasing emphasis on cardiovascular disease in women and study of female-specific cardiovascular risk factors. Hypertension in pregnancy, and specifically preeclampsia, has been identified as one such risk factor. In this review, we explore the epidemiological evidence for preeclampsia as a risk factor for cardiovascular disease. We propose reasons for this association, giving evidence for potential pathways linking preeclampsia with future cardiovascular disease.

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References

Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance

  1. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2095–128. doi:10.1016/S0140-6736(12)61728-0. Important global epidemiologic study which shifts the paradigm in our understanding of disease burden worldwide.Cardiovascular disease is now understood to be the major cause of death even in low and middle income countries, rather than communicable diseases.

    Article  PubMed  Google Scholar 

  2. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics–2014 update: a report from the American Heart Association. Circulation. 2014;129(3):e28–e292. doi:10.1161/01.cir.0000441139.02102.80.

    Article  PubMed  Google Scholar 

  3. Report of the American College of Obstetricians and Gynecologists' Task Force on Hypertension in Pregnancy. Hypertension in pregnancy. Obstet Gynecol. 2013;122(5):1122–31. doi:10.1097/01.AOG.0000437382.03963.88. Recently updated gudelines on hypertension in pregnancy. Of importance is the decreased emphasis on proteinuria to make the diagnosis of preeclampsia, and the inclusion of any end-organ dysfunction.

  4. Dolea C, AbouZahr C. Global burden of hypertensive disorders of pregnancy in the year 2000. In: Evidence and Information for Policy (EIP), World Health Organization. 2003. http://www.who.int/healthinfo/statistics/bod_hypertensivedisordersofpregnancy.pdf.

  5. Ananth CV, Lawrence CK. Pre-eclampsia and cardiovascular disease: more questions than answers? Bjog. 2013;120(8):920–3. doi:10.1111/1471-0528.12215.

    Article  CAS  PubMed  Google Scholar 

  6. Corwin J, Herrick WW. Relation of Hypertensive Toxemia of Pregnancy to Chronic Cardiovascular Disease. JAMA: The Journal of the American Medical Association. 1927;88(7):457. doi:10.1001/jama.1927.02680330009003.

    Article  Google Scholar 

  7. Lin YS, Tang CH, Yang CY, Wu LS, Hung ST, Hwa HL, et al. Effect of pre-eclampsia-eclampsia on major cardiovascular events among peripartum women in Taiwan. Am J Cardiol. 2011;107(2):325–30. doi:10.1016/j.amjcard.2010.08.073. Large epidemiological study showing increased rates of major adverse cardiovascular events in Taiwanese women with a history of preeclampsia. Prior to this, studies such as this have been conducted in predominantly white populations.

    Article  PubMed  Google Scholar 

  8. Ray JG, Vermeulen MJ, Schull MJ, Redelmeier DA. Cardiovascular health after maternal placental syndromes (CHAMPS): population-based retrospective cohort study. Lancet. 2005;366(9499):1797–803. doi:10.1016/s0140-6736(05)67726-4.

    Article  PubMed  Google Scholar 

  9. Irgens HU, Reisaeter L, Irgens LM, Lie RT. Long term mortality of mothers and fathers after pre-eclampsia: population based cohort study. BMJ. 2001;323(7323):1213–7.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  10. Lykke JA, Langhoff-Roos J, Sibai BM, Funai EF, Triche EW, Paidas MJ. Hypertensive pregnancy disorders and subsequent cardiovascular morbidity and type 2 diabetes mellitus in the mother. Hypertension. 2009;53(6):944–51. doi:10.1161/hypertensionaha.109.130765.

    Article  CAS  PubMed  Google Scholar 

  11. Wikstrom AK, Haglund B, Olovsson M, Lindeberg SN. The risk of maternal ischaemic heart disease after gestational hypertensive disease. Bjog. 2005;112(11):1486–91. doi:10.1111/j.1471-0528.2005.00733.x.

    Article  PubMed  Google Scholar 

  12. Kestenbaum B, Seliger SL, Easterling TR, Gillen DL, Critchlow CW, Stehman-Breen CO, et al. Cardiovascular and thromboembolic events following hypertensive pregnancy. Am J Kidney Dis. 2003;42(5):982–9.

    Article  PubMed  Google Scholar 

  13. Garovic VD, Bailey KR, Boerwinkle E, Hunt SC, Weder AB, Curb D, et al. Hypertension in pregnancy as a risk factor for cardiovascular disease later in life. J Hypertens. 2010;28(4):826–33. doi:10.1097/HJH.0b013e328335c29a.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  14. Hannaford P, Ferry S, Hirsch S. Cardiovascular sequelae of toxaemia of pregnancy. Heart. 1997;77(2):154–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  15. Smith GC, Pell JP, Walsh D. Pregnancy complications and maternal risk of ischaemic heart disease: a retrospective cohort study of 129,290 births. Lancet. 2001;357(9273):2002–6. doi:10.1016/s0140-6736(00)05112-6.

    Article  CAS  PubMed  Google Scholar 

  16. Wilson BJ, Watson MS, Prescott GJ, Sunderland S, Campbell DM, Hannaford P, et al. Hypertensive diseases of pregnancy and risk of hypertension and stroke in later life: results from cohort study. BMJ. 2003;326(7394):845. doi:10.1136/bmj.326.7394.845.

    Article  PubMed Central  PubMed  Google Scholar 

  17. Bellamy L, Casas JP, Hingorani AD, Williams DJ. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: systematic review and meta-analysis. BMJ. 2007;335(7627):974. doi:10.1136/bmj.39335.385301.BE.

    Article  PubMed Central  PubMed  Google Scholar 

  18. McDonald SD, Malinowski A, Zhou Q, Yusuf S, Devereaux PJ. Cardiovascular sequelae of preeclampsia/eclampsia: a systematic review and meta-analyses. Am Heart J. 2008;156(5):918–30. doi:10.1016/j.ahj.2008.06.042.

    Article  PubMed  Google Scholar 

  19. Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women-2011 update a guideline from the american heart association. J Am Coll Cardiol. 2011;57(12):1404–23. doi:10.1016/j.jacc.2011.02.005.

    Article  PubMed Central  PubMed  Google Scholar 

  20. Mannisto T, Mendola P, Vaarasmaki M, Jarvelin MR, Hartikainen AL, Pouta A, et al. Elevated blood pressure in pregnancy and subsequent chronic disease risk. Circulation. 2013;127(6):681–90. doi:10.1161/CIRCULATIONAHA.112.128751. Demonstration that any degree of hypertension in pregnancy is associated with an increased risk for cardiovascular disease. Previous reports conflicted on whether 'milder' forms of hypertensive pregnancy were associated with increased risk.

    Article  PubMed  Google Scholar 

  21. Ros HS, Cnattingius S, Lipworth L. Comparison of risk factors for preeclampsia and gestational hypertension in a population-based cohort study. Am J Epidemiol. 1998;147(11):1062–70.

    Article  CAS  PubMed  Google Scholar 

  22. Gaillard R, Steegers EA, Hofman A, Jaddoe VW. Associations of maternal obesity with blood pressure and the risks of gestational hypertensive disorders. The Generation R Study J Hypertens. 2011;29(5):937–44. doi:10.1097/HJH.0b013e328345500c.

    CAS  Google Scholar 

  23. Bodnar LM, Catov JM, Klebanoff MA, Ness RB, Roberts JM. Prepregnancy body mass index and the occurrence of severe hypertensive disorders of pregnancy. Epidemiology. 2007;18(2):234–9. doi:10.1097/01.ede.0000254119.99660.e7.

    Article  PubMed  Google Scholar 

  24. Magnussen EB, Vatten LJ, Lund-Nilsen TI, Salvesen KA, Davey Smith G, Romundstad PR. Prepregnancy cardiovascular risk factors as predictors of pre-eclampsia: population based cohort study. BMJ. 2007;335(7627):978. doi:10.1136/bmj.39366.416817.BE.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Duckitt K, Harrington D. Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies. BMJ. 2005;330(7491):565. doi:10.1136/bmj.38380.674340.E0.

    Article  PubMed Central  PubMed  Google Scholar 

  26. Bryson CL, Ioannou GN, Rulyak SJ, Critchlow C. Association between gestational diabetes and pregnancy-induced hypertension. Am J Epidemiol. 2003;158(12):1148–53.

    Article  PubMed  Google Scholar 

  27. Ray JG, Vermeulen MJ, Schull MJ, McDonald S, Redelmeier DA. Metabolic syndrome and the risk of placental dysfunction. J Obstet Gynaecol Can. 2005;27(12):1095–101.

    PubMed  Google Scholar 

  28. McDonald SD, Yusuf S, Walsh MW, Lonn E, Teo K, Anand SS, et al. Increased cardiovascular risk after pre-eclampsia in women with dysglycaemia. Diabetic medicine : a journal of the British Diabetic Association. 2013;30(1):e1–7. doi:10.1111/dme.12033. Even among a group of women with altered glucose homeostasis, the addition of preeclampsia confers an even higher risk of future cardiovascular disease. This association was shown to be independent of known cardiovascular risk factors, implying that preeclampsia itself may be an independent risk factor for cardiovascular disease.

    Article  CAS  Google Scholar 

  29. Meekins JW, Pijnenborg R, Hanssens M, McFadyen IR, van Asshe A. A study of placental bed spiral arteries and trophoblast invasion in normal and severe pre-eclamptic pregnancies. Br J Obstet Gynaecol. 1994;101(8):669–74.

    Article  CAS  PubMed  Google Scholar 

  30. Khong TY, De Wolf F, Robertson WB, Brosens I. Inadequate maternal vascular response to placentation in pregnancies complicated by pre-eclampsia and by small-for-gestational age infants. Br J Obstet Gynaecol. 1986;93(10):1049–59.

    Article  CAS  PubMed  Google Scholar 

  31. Burton GJ, Woods AW, Jauniaux E, Kingdom JC. Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy. Placenta. 2009;30(6):473–82. doi:10.1016/j.placenta.2009.02.009.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  32. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, et al. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111(5):649–58. doi:10.1172/JCI17189.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  33. Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, et al. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med. 2006;12(6):642–9. doi:10.1038/nm1429.

    Article  CAS  PubMed  Google Scholar 

  34. Sandrim VC, Palei AC, Metzger IF, Gomes VA, Cavalli RC, Tanus-Santos JE. Nitric oxide formation is inversely related to serum levels of antiangiogenic factors soluble fms-like tyrosine kinase-1 and soluble endogline in preeclampsia. Hypertension. 2008;52(2):402–7. doi:10.1161/HYPERTENSIONAHA.108.115006.

  35. Craici IM, Wagner SJ, Weissgerber TL, Grande JP, Garovic VD. Advances in the pathophysiology of pre-eclampsia and related podocyte injury. Kidney Int. 2014. doi:10.1038/ki.2014.17.

    Google Scholar 

  36. Herse F, Lamarca B. Angiotensin II Type 1 Receptor Autoantibody (AT1-AA)-Mediated Pregnancy Hypertension. Am J Reprod Immunol. 2013;69(4):413–8. doi:10.1111/aji.12072.

    Article  CAS  PubMed  Google Scholar 

  37. Wagner SJ, Craici IM, Grande JP, Garovic VD. From placenta to podocyte: vascular and podocyte pathophysiology in preeclampsia. Clin Nephrol. 2012;78(3):241–9.

    Article  CAS  PubMed  Google Scholar 

  38. Chambers JC, Fusi L, Malik IS, Haskard DO, De Swiet M, Kooner JS. Association of maternal endothelial dysfunction with preeclampsia. Jama. 2001;285(12):1607–12.

    Article  CAS  PubMed  Google Scholar 

  39. Agatisa PK, Ness RB, Roberts JM, Costantino JP, Kuller LH, McLaughlin MK. Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk. Am J Physiol Heart Circ Physiol. 2004;286(4):H1389–93. doi:10.1152/ajpheart.00298.2003.

    Article  CAS  PubMed  Google Scholar 

  40. Germain AM, Romanik MC, Guerra I, Solari S, Reyes MS, Johnson RJ, et al. Endothelial dysfunction: a link among preeclampsia, recurrent pregnancy loss, and future cardiovascular events? Hypertension. 2007;49(1):90–5. doi:10.1161/01.HYP.0000251522.18094.d4.

    Article  CAS  PubMed  Google Scholar 

  41. Hamad RR, Eriksson MJ, Silveira A, Hamsten A, Bremme K. Decreased flow-mediated dilation is present 1 year after a pre-eclamptic pregnancy. J Hypertens. 2007;25(11):2301–7. doi:10.1097/HJH.0b013e3282ef5fc0.

    Article  CAS  PubMed  Google Scholar 

  42. Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, et al. Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk. Circulation. 2010;122(18):1846–53. doi:10.1161/CIRCULATIONAHA.110.948455.

    Article  CAS  PubMed  Google Scholar 

  43. Bytautiene E, Bulayeva N, Bhat G, Li L, Rosenblatt KP, Saade GR. Long-term alterations in maternal plasma proteome after sFlt1-induced preeclampsia in mice. Am J Obstet Gynecol. 2013;208(5):388 e1–e10. doi:10.1016/j.ajog.2013.01.042. This animal model of preeclampsia demonstrated that induction of preeclampsia resulted in a plasma proteome that is associated with increased cardiovascular risk even when evaluated long after pregnancy.

    Article  Google Scholar 

  44. Lerman A, Cannan CR, Higano SH, Nishimura RA, Holmes Jr DR. Coronary vascular remodeling in association with endothelial dysfunction. Am J Cardiol. 1998;81(9):1105–9.

    Article  CAS  PubMed  Google Scholar 

  45. Gutierrez E, Flammer AJ, Lerman LO, Elizaga J, Lerman A, Fernandez-Aviles F. Endothelial dysfunction over the course of coronary artery disease. Eur Heart J. 2013;34(41):3175–81. doi:10.1093/eurheartj/eht351.

    Article  PubMed  Google Scholar 

  46. Ostlund E, Al-Nashi M, Hamad RR, Larsson A, Eriksson M, Bremme K, et al. Normalized endothelial function but sustained cardiovascular risk profile 11 years following a pregnancy complicated by preeclampsia. Hypertension research : official journal of the Japanese Society of Hypertension. 2013;36(12):1081–7. doi:10.1038/hr.2013.81.

    Article  Google Scholar 

  47. Stekkinger E, Zandstra M, Peeters LL, Spaanderman ME. Early-onset preeclampsia and the prevalence of postpartum metabolic syndrome. Obstet Gynecol. 2009;114(5):1076–84. doi:10.1097/AOG.0b013e3181b7b242.

    Article  PubMed  Google Scholar 

  48. Pouta A, Hartikainen A-L, Sovio U, Gissler M, Laitinen J, McCarthy MI, et al. Manifestations of Metabolic Syndrome After Hypertensive Pregnancy. Hypertension. 2004;43(4):825–31. doi:10.1161/01.hyp.0000120122.39231.88.

    Article  CAS  PubMed  Google Scholar 

  49. Callaway LK, McIntyre HD, O'Callaghan M, Williams GM, Najman JM, Lawlor DA. The association of hypertensive disorders of pregnancy with weight gain over the subsequent 21 years: findings from a prospective cohort study. Am J Epidemiol. 2007;166(4):421–8. doi:10.1093/aje/kwm099.

    Article  PubMed  Google Scholar 

  50. Magnussen EB, Vatten LJ, Smith GD, Romundstad PR. Hypertensive disorders in pregnancy and subsequently measured cardiovascular risk factors. Obstet Gynecol. 2009;114(5):961–70. doi:10.1097/AOG.0b013e3181bb0dfc.

    Article  PubMed  Google Scholar 

  51. Stekkinger E, Scholten R, van der Vlugt MJ, van Dijk AP, Janssen MC, Spaanderman ME. Metabolic syndrome and the risk for recurrent pre-eclampsia: a retrospective cohort study. Bjog. 2013;120(8):979–86. doi:10.1111/1471-0528.12189.

    Article  CAS  PubMed  Google Scholar 

  52. Rodie VA, Freeman DJ, Sattar N, Greer IA. Pre-eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? Atherosclerosis. 2004;175(2):189–202. doi:10.1016/j.atherosclerosis.2004.01.038.

    Article  CAS  PubMed  Google Scholar 

  53. Kattah AG, Asad R, Scantlebury DC, Bailey KR, Wiste HJ, Hunt SC, et al. Hypertension in pregnancy is a risk factor for microalbuminuria later in life. J Clin Hypertens (Greenwich). 2013;15(9):617–23. doi:10.1111/jch.12116. Evidence of either persistent or recurrent renal injury many years following hypertensive pregnancy.

    Article  Google Scholar 

  54. Gerstein HC, Mann JF, Yi Q, Zinman B, Dinneen SF, Hoogwerf B, et al. Albuminuria and risk of cardiovascular events, death, and heart failure in diabetic and nondiabetic individuals. Jama. 2001;286(4):421–6.

    Article  CAS  PubMed  Google Scholar 

  55. Vikse BE, Irgens LM, Leivestad T, Skjaerven R, Iversen BM. Preeclampsia and the risk of end-stage renal disease. N Engl J Med. 2008;359(8):800–9. doi:10.1056/NEJMoa0706790.

    Article  CAS  PubMed  Google Scholar 

  56. Wang IK, Muo CH, Chang YC, Liang CC, Chang CT, Lin SY, et al. Association between hypertensive disorders during pregnancy and end-stage renal disease: a population-based study. CMAJ. 2013;185(3):207–13. doi:10.1503/cmaj.120230. Study demonstrating that preeclampsia-eclampsia had a very strong association with endstage renal disease (adjusted HR 14).

    Article  PubMed Central  PubMed  Google Scholar 

  57. Wu CC, Chen SH, Ho CH, Liang FW, Chu CC, Wang HY, et al. End-stage renal disease after hypertensive disorders in pregnancy. Am J Obstet Gynecol. 2014;210(2):147 e1–8. doi:10.1016/j.ajog.2013.09.027. Similar findings as the above study. Women who had preeclampsia superimposed on chronic hypertension had the strongest association with end-stage renal disease.

    Article  Google Scholar 

  58. Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108(17):2154–69. doi:10.1161/01.CIR.0000095676.90936.80.

    Article  PubMed  Google Scholar 

  59. Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin Proc. 2008;83(11):1203–12. doi:10.4065/83.11.1203.

    Article  PubMed  Google Scholar 

  60. White WM, Turner ST, Bailey KR, Mosley Jr TH, Kardia SL, Wiste HJ, et al. Hypertension in pregnancy is associated with elevated homocysteine levels later in life. Am J Obstet Gynecol. 2013;209(5):454 e1–7. doi:10.1016/j.ajog.2013.06.030.

    Article  Google Scholar 

  61. Visser S, Hermes W, Ket JC, Otten RH, Van Pampus MG, Bloemenkamp KW, et al. Systematic Review and Meta-analysis on Non-classic Cardiovascular Biomarkers after Hypertensive Pregnancy Disorders. Am J Obstet Gynecol. 2014. doi:10.1016/j.ajog.2014.03.032.

    Google Scholar 

  62. Campos O. Doppler Echocardiography During Pregnancy: Physiological and Abnormal Findings. Echocardiography. 1996;13(2):135–46.

    Article  PubMed  Google Scholar 

  63. Savu O, Jurcut R, Giusca S, van Mieghem T, Gussi I, Popescu BA, et al. Morphological and functional adaptation of the maternal heart during pregnancy. Circulation Cardiovascular imaging. 2012;5(3):289–97. doi:10.1161/CIRCIMAGING.111.970012.

    Article  PubMed  Google Scholar 

  64. Zanati Bazan SG, Borges VM, Martin LC, Magalhaes CG, Hueb JC, de Arruda Silveira LV, et al. Disproportionate Pregnancy-Induced Myocardial Hypertrophy in Women With Essential Hypertension. Am J Hypertens. 2013. doi:10.1093/ajh/hpt023.

    PubMed  Google Scholar 

  65. Melchiorre K, Sutherland GR, Baltabaeva A, Liberati M, Thilaganathan B. Maternal cardiac dysfunction and remodeling in women with preeclampsia at term. Hypertension. 2011;57(1):85–93. doi:10.1161/HYPERTENSIONAHA.110.162321. One of the few contemporary echocardiographic studies showing myocardial structural and functional changes in preeclamptic pregnancy.

    Article  CAS  PubMed  Google Scholar 

  66. Ingec M, Yilmaz M, Gundogdu F. Left atrial mechanical functions in pre-eclampsia. J Obstet Gynaecol Res. 2005;31(6):535–9. doi:10.1111/j.1447-0756.2005.00332.x.

    Article  PubMed  Google Scholar 

  67. Melchiorre K, Sutherland GR, Watt-Coote I, Liberati M, Thilaganathan B. Severe myocardial impairment and chamber dysfunction in preterm preeclampsia. Hypertens Pregnancy. 2012;31(4):454–71. doi:10.3109/10641955.2012.697951.

    Article  PubMed  Google Scholar 

  68. Melchiorre K, Sutherland GR, Liberati M, Thilaganathan B. Preeclampsia is associated with persistent postpartum cardiovascular impairment. Hypertension. 2011;58(4):709–15. doi:10.1161/HYPERTENSIONAHA.111.176537. Strong evidence for persistent myocardial structural and functional changes following preeclamptic pregnancy.

    Article  CAS  PubMed  Google Scholar 

  69. Strobl I, Windbichler G, Strasak A, Weiskopf-Schwendinger V, Schweigmann U, Ramoni A, et al. Left ventricular function many years after recovery from pre-eclampsia. Bjog. 2011;118(1):76–83. doi:10.1111/j.1471-0528.2010.02780.x.

    Article  CAS  PubMed  Google Scholar 

  70. Ray JG, Schull MJ, Kingdom JC, Vermeulen MJ. Heart failure and dysrhythmias after maternal placental syndromes: HAD MPS Study. Heart. 2012;98(15):1136–41. doi:10.1136/heartjnl-2011-301548. Women with a history of placental syndromes have a higher risk of heart failure and arrhythmias even after adjusting for traditional risk factors. This was the first study to demonstrate this association, and gives credence to echocardiographic studies that show myocardial structural and functional changes.

    Article  PubMed  Google Scholar 

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Dawn C Scantlebury and Sharonne N. Hayes declare that they have no conflict of interest.

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  1. Division of Cardiovacular Disease, Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA

    Dawn C. Scantlebury & Sharonne N. Hayes

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Correspondence to Dawn C. Scantlebury.

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Scantlebury, D.C., Hayes, S.N. How Does Preeclampsia Predispose to Future Cardiovascular Disease?. Curr Hypertens Rep 16, 472 (2014). https://doi.org/10.1007/s11906-014-0472-6

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