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Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia

  • Chronic Leukemias (J Goldman, Section Editor)
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Abstract

In recent years new, more potent tyrosine-kinase inhibitors have been introduced to accompany imatinib for the treatment of chronic myeloid leukemia. Most patients in chronic phase obtain an optimal response to these oral agents with minimal toxicity. Allogeneic stem cell transplantation is therefore indicated only in a minority of patients who do not achieve an adequate response to first, second or third generation agents. Patients in accelerated phase have a lower chance of achieving an optimal response on these drugs. For patients in blast phase, transplantation remains the only therapy with curative potential, although now it is increasingly used in combination with tyrosine-kinase inhibitors. In this review we address the role of allogeneic stem cell transplantation in the treatment of this disease and how patients should be transplanted.

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Acknowledgment

The authors are grateful for support from the National Institute for Health Research Biomedical Research Centre funding scheme.

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  1. Imperial College London at Hammersmith Hospital, London, UK

    Jiří Pavlů & Jane F. Apperley

  2. Department of Haematology, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Room 2.20 Catherine Lewis Centre, Du Cane Road, London, W12 0HS, UK

    Jiří Pavlů

  3. Centre for Haematology, Faculty of Medicine, Commonwealth Building, Imperial College London, Du Cane Road, London, W12 0NN, UK

    Jane F. Apperley

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Correspondence to Jiří Pavlů.

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Pavlů, J., Apperley, J.F. Allogeneic Stem Cell Transplantation for Chronic Myeloid Leukemia. Curr Hematol Malig Rep 8, 43–51 (2013). https://doi.org/10.1007/s11899-012-0149-7

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