Skip to main content
Log in

Minimally invasive pancreatic surgery: the new frontier?

  • Published:
Current Gastroenterology Reports Aims and scope Submit manuscript

Abstract

Recent advances in minimally invasive pancreatic surgery encompass laparoscopic, retroperitoneoscopic, endoscopic, thoracoscopic, and percutaneous approaches. Applications of endoscopic pancreatic surgery include laparoscopic resection, necrosectomy, drainage of pseudocysts, gastric and biliary bypass, and thoracoscopic splanchnotomy. This review provides an update on laparoscopic pancreatic resections. Over 400 cases of laparoscopic distal pancreatectomy (LDP) and enucleation (LEn) have been reported in the English literature, largely for benign disease. LDP and LEn have been associated with reductions in blood loss, morbidity, and hospital stay and a greater rate of splenic preservation compared with open surgery. Laparoscopic ultrasound is essential for intraoperative localization of insulinomas because failure of localization is the most common cause for conversion to laparotomy. The role of LDP with en bloc splenectomy and laparoscopic pancreaticoduodenectomy (LPD) for malignancy remains controversial. The majority of LPDs have been performed for malignancy. The short-term results of the limited world experience of 34 reported LPDs appear favorable.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References and Recommended Reading

  1. Mabrut JY, Fernandez-Cruz L, Azagra JS, et al.: Hepatobiliary and Pancreatic Section (HBPS) of the Royal Belgian Society of Surgery; Belgian Group for Endoscopic Surgery (BGES); Club Coelio. Laparoscopic pancreatic resection: results of a multicenter European study of 127 patients. Surgery 2005, 137:597–605. This is the largest series of laparoscopic pancreatic resections.

    Article  PubMed  Google Scholar 

  2. Ayav A, Bresler L, Brunaud L, et al.: Laparoscopic approach for solitary insulinoma: a multicentre study. Langenbecks Arch Surg 2005, 390:134–140. This French study is the second largest series of LDP and LEn (34 patients). The spleen was preserved in 80% of patients undergoing LDP.

    Article  PubMed  CAS  Google Scholar 

  3. Dulucq JL, Wintringer P, Stabilini C, et al.: Are major laparoscopic pancreatic resections worthwhile? A prospective study of 32 patients in a single institution. Surg Endosc 2005, 19:1028–1034. This is the largest series of laparoscopic pancreaticoduodenectomy (11 patients).

    Article  PubMed  CAS  Google Scholar 

  4. Lebedyev A, Zmora O, Kuriansky J, et al.: Laparoscopic distal pancreatectomy. Surg Endosc 2004, 18:1427–1430.

    Article  PubMed  CAS  Google Scholar 

  5. Fernandez-Cruz L, Martinez I, Cesar-Borges G, et al.: Laparoscopic surgery in patients with sporadic and multiple insulinomas associated with multiple endocrine neoplasia type 1. J Gastrointest Surg 2005, 9:381–388. This is the largest series of laparoscopic pancreatic resection for insulinoma in patients with MEN-1 syndrome.

    Article  PubMed  Google Scholar 

  6. Edwin B, Mala T, Mathisen O, et al.: Laparoscopic resection of the pancreas: a feasibility study of the short-term outcome. Surg Endosc 2004, 18:407–411.

    Article  PubMed  CAS  Google Scholar 

  7. Shimizu S, Tanaka M, Konomi H, et al.: Laparoscopic pancreatic surgery: current indications and surgical results. Surg Endosc 2004, 18:402–406.

    Article  PubMed  CAS  Google Scholar 

  8. Fernandez-Cruz L, Martinez I, Gilabert R, et al.: Laparoscopic distal pancreatectomy combined with preservation of the spleen for cystic neoplasms of the pancreas. J Gastrointest Surg 2004, 8:493–501.

    Article  PubMed  Google Scholar 

  9. Fabre JM, Dulucq JL, Vacher C, et al.: Is laparoscopic left pancreatic resection justified? Surg Endosc 2002, 16:1358–1361.

    Article  PubMed  CAS  Google Scholar 

  10. Park AE, Heniford BT: Therapeutic laparoscopy of the pancreas. Ann Surg 2002, 236:149–158.

    Article  PubMed  Google Scholar 

  11. Fernandez-Cruz L, Saenz A, Astudillo E, et al.: Outcome of laparoscopic pancreatic surgery: endocrine and nonendocrine tumors. World J Surg 2002, 26:1057–1065.

    Article  PubMed  CAS  Google Scholar 

  12. Patterson EJ, Gagner M, Salky B, et al.: Laparoscopic pancreatic resection: single-institution experience of 19 patients. J Am Coll Surg 2001, 193:281–287.

    Article  PubMed  CAS  Google Scholar 

  13. Berends FJ, Cuesta MA, Kazemier G, et al.: Laparoscopic detection and resection of insulinomas. Surgery 2000, 128:386–391.

    Article  PubMed  CAS  Google Scholar 

  14. Cuschieri SA, Jakimowicz JJ: Laparoscopic pancreatic resections. Semin Laparosc Surg 1998, 5:168–179.

    PubMed  CAS  Google Scholar 

  15. Gagner M, Pomp A: Laparoscopic pancreatic resection: Is it worthwhile? J Gastrointest Surg 1997, 1:20–26.

    Article  PubMed  CAS  Google Scholar 

  16. Gagner M, Pomp A: Laparoscopic pylorus-preserving pancreatoduodenectomy. Surg Endosc 1994, 8:408–410.

    Article  PubMed  CAS  Google Scholar 

  17. Kimura Y, Hirata K, Mukaiya M, et al.: Hand-assisted laparoscopic pylorus-preserving pancreaticoduodenectomy for pancreas head disease. Am J Surg 2005, 189:734–737.

    Article  PubMed  Google Scholar 

  18. Staudacher C, Orsenigo E, Baccari P, et al.: Laparoscopic assisted duodenopancreatectomy. Surg Endosc 2005, 19:352–356.

    Article  PubMed  CAS  Google Scholar 

  19. Ammori BJ: Laparoscopic hand-assisted pancreaticoduodenectomy: initial UK experience. Surg Endosc 2004, 18:717–718.

    Article  Google Scholar 

  20. Uyama I, Ogiwara H, Iida S, et al.: Laparoscopic minilaparotomy pancreaticoduodenectomy with lymphadenectomy using an abdominal wall-lift method. Surg Laparosc Endosc 1996, 6:405–410.

    Article  PubMed  CAS  Google Scholar 

  21. Mignon M: Natural history of neuroendocrine enteropancreatic tumors. Digestion 2000, 62:51–58.

    Article  PubMed  Google Scholar 

  22. Noone TC, Hosey J, Firat Z, et al.: Imaging and localization of islet-cell tumours of the pancreas on CT and MRI. Best Pract Res Clin Endocrinol Metab 2005, 19:195–211.

    Article  PubMed  Google Scholar 

  23. Anderson MA, Carpenter S, Thompson NW, et al.: Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol 2000, 95:2271–2277.

    Article  PubMed  CAS  Google Scholar 

  24. Chavan A, Kirchhoff TD, Brabant G, et al.: Role of the intra-arterial calcium stimulation test in the preoperative localization of insulinomas. Eur Radiol 2000, 10:1582–1586.

    Article  PubMed  CAS  Google Scholar 

  25. Saga T, Shimatsu A, Koizumi K, et al.: Morphological imaging in the localization of neuroendocrine gastroenteropancreatic tumors found by somatostatin receptor scintigraphy. Acta Radiol 2005, 46:227–232.

    Article  PubMed  CAS  Google Scholar 

  26. Hashimoto LA, Walsh RM: Preoperative localization of insulinomas is not necessary. J Am Coll Surg 1999, 189:368–373.

    Article  PubMed  CAS  Google Scholar 

  27. Talamini MA, Moesinger R, Yeo CJ, et al.: Cystadenomas of the pancreas: is enucleation an adequate operation? Ann Surg 1998, 227:896–903.

    Article  PubMed  CAS  Google Scholar 

  28. Goh PM, Khan AZ, So JB, et al.: Early experience with laparoscopic radical gastrectomy for advanced gastric cancer. Surg Laparosc Endosc Percutan Tech 2001, 11:83–87.

    Article  PubMed  CAS  Google Scholar 

  29. Warshaw AL: Conservation of the spleen with distal pancreatectomy. Arch Surg 1988, 123:550–553.

    PubMed  CAS  Google Scholar 

  30. Ejstrud P, Kristensen B, Hansen JB, et al.: Risk and patterns of bacteraemia after splenectomy: a population-based study. Scand J Infect Dis 2000, 32:521–525. Post-splenectomy bacteremia occurred within 30 days of surgery in 45% of patients and was eight times greater thereafter than in the non-splenectomized patients at 2.3 per 100 person-years at risk.

    Article  PubMed  CAS  Google Scholar 

  31. Shoup M, Brennan MF, McWhite K, et al.: The value of splenic preservation with distal pancreatectomy. Arch Surg 2002, 137:164–168.

    Article  PubMed  Google Scholar 

  32. Griffith JP, Sue-Ling HM, Martin I, et al.: Preservation of the spleen improves survival after radical surgery for gastric cancer. Gut 1995, 36:684–690.

    PubMed  CAS  Google Scholar 

  33. Schwarz RE, Harrison LE, Conlon KC, et al.: The impact of splenectomy on outcomes after resection of pancreatic adenocarcinoma. J Am Coll Surg 1999, 188:516–521.

    Article  PubMed  CAS  Google Scholar 

  34. Lillemoe KD, Kaushal S, Cameron JL, et al.: Distal pancreatectomy: indications and outcomes in 235 patients. Ann Surg 1999, 229:693–700. This study from Johns Hopkins represents the largest single-institution experience of open distal pancreatectomy in the world literature.

    Article  PubMed  CAS  Google Scholar 

  35. Fahy BN, Frey CF, Ho HS, et al.: Morbidity, mortality, and technical factors of distal pancreatectomy. Am J Surg 2002, 183:237–241.

    Article  PubMed  Google Scholar 

  36. Yeo CJ, Cameron JL, Lillemoe KD, et al.: Pancreaticoduodenectomy with or without distal gastrectomy and extended retroperitoneal lymphadenectomy for periampullary adenocarcinoma, part 2: randomized controlled trial evaluating survival, morbidity, and mortality. Ann Surg 2002, 236:355–368. This is the largest study (299 patients) showing increased morbidity with extended resection with no survival advantage.

    Article  PubMed  Google Scholar 

  37. Montorsi M, Zago M, Mosca F, et al.: Efficacy of octreotide in the prevention of pancreatic fistula after elective pancreatic resections: a prospective, controlled, randomized clinical trial. Surgery 1995, 117:26–31.

    Article  PubMed  CAS  Google Scholar 

  38. Benoist S, Dugue L, Sauvanet A, et al.: Is there a role of preservation of the spleen in distal pancreatectomy? J Am Coll Surg 1999, 188:255–260.

    Article  PubMed  CAS  Google Scholar 

  39. Sarr MG; Pancreatic Surgery Group. The potent somatostatin analogue vapreotide does not decrease pancreas-specific complications after elective pancreatectomy: a prospective, multicenter, double-blinded, randomized, placebo-controlled trial. J Am Coll Surg 2003, 196:556–565. This study of 275 patients showed no benefit to vapreotide in patients without chronic pancreatitis.

    Article  PubMed  Google Scholar 

  40. Buchler M, Friess H, Klempa I, et al.: Role of octreotide in the prevention of postoperative complications following pancreatic resection. Am J Surg 1992, 163:125–130.

    Article  PubMed  CAS  Google Scholar 

  41. Ohwada S, Ogawa T, Tanahashi Y, et al.: Fibrin glue sandwich prevents pancreatic fistula following distal pancreatectomy. World J Surg 1998, 22:494–498.

    Article  PubMed  CAS  Google Scholar 

  42. Suzuki Y, Fujino Y, Tanioka Y, et al.: Randomized clinical trial of ultrasonic dissector or conventional division in distal pancreatectomy for non-fibrotic pancreas. Br J Surg, 1999, 86:608–611.

    Article  PubMed  CAS  Google Scholar 

  43. Bilimoria MM, Cormier JN, Mun Y, et al.: Pancreatic leak after left pancreatectomy is reduced following main pancreatic duct ligation. Br J Surg 2003, 90:190–196. Identification of the pancreatic duct and suture ligation were performed in 73 of 126 patients who underwent distal pancreatectomy and were associated with a significantly lower pancreatic fistula rate (9.6% vs 34%, P > 0.001).

    Article  PubMed  CAS  Google Scholar 

  44. Kiely JM, Nakeeb A, Komorowski RA, et al.: Cystic pancreatic neoplasms: enucleate or resect? J Gastrointest Surg 2003, 7:890–897.

    Article  PubMed  Google Scholar 

  45. Fernandez-Cruz L, Saenz A, Astudillo E, et al.: Laparoscopic pancreatic surgery in patients with chronic pancreatitis. Surg Endosc 2002, 16:996–1003.

    Article  PubMed  CAS  Google Scholar 

  46. Tan M, Kandaswamy R, Sutherland DE, et al.: Laparoscopic donor distal pancreatectomy for living donor pancreas and pancreas-kidney transplantation. Am J Transplant 2005, 5:1966–1970.

    Article  PubMed  Google Scholar 

  47. Ammori BJ, El-Dhuwaib Y, Ballester P, et al.: Laparoscopic distal pancreatectomy for neuroendocrine tumors of the pancreas. Hepatogastroenterology 2005, 52:620–624.

    PubMed  Google Scholar 

  48. Veldkamp R, Kuhry E, Hop WC, et al.; COlon cancer Laparoscopic or Open Resection Study Group (COLOR). Laparoscopic surgery versus open surgery for colon cancer: short-term outcomes of a randomised trial. Lancet Oncol 2005, 6:477–484.

    Article  PubMed  Google Scholar 

  49. Leung KL, Kwok SP, Lam SC, et al.: Laparoscopic resection of rectosigmoid carcinoma: prospective randomised trial. Lancet 2004, 363:1187–1192.

    Article  PubMed  Google Scholar 

  50. Jacob BP, Salky B: Laparoscopic colectomy for colon adenocarcinoma: an 11-year retrospective review with 5-year survival rates. Surg Endosc 2005, 19:643–649.

    Article  PubMed  CAS  Google Scholar 

  51. Schmidt CM, Powell ES, Yiannoutsos CT, et al.: Pancreaticoduodenectomy: a 20-year experience in 516 patients. Arch Surg 2004, 139:718–725.

    Article  PubMed  Google Scholar 

  52. Schafer M, Mullhaupt B, Clavien PA: Evidence-based pancreatic head resection for pancreatic cancer and chronic pancreatitis. Ann Surg 2002, 236:137–148.

    Article  PubMed  Google Scholar 

  53. Sohn TA, Yeo CJ, Cameron JL, et al.: Resected adenocarcinoma of the pancreas-616 patients: results, outcomes, and prognostic indicators. J Gastrointest Surg 2000, 4:567–579.

    Article  PubMed  CAS  Google Scholar 

  54. Pedrazzoli S, DiCarlo V, Dionigi R, et al.: Standard versus extended lymphadenectomy associated with pancreatoduodenectomy in the surgical treatment of adenocarcinoma of the head of the pancreas: a multicenter, prospective, randomized study. Lymphadenectomy Study Group. Ann Surg 1998, 228:508–517. In this underpowered study of 81 patients, an unplanned subgroup analysis showed a trend toward longer survival in node-positive patients treated with extended resection.

    Article  PubMed  CAS  Google Scholar 

  55. Farnell MB, Pearson RK, Sarr MG, et al.; Pancreas Cancer Working Group. A prospective randomized trial comparing standard pancreatoduodenectomy with pancreatoduodenectomy with extended lymphadenectomy in resectable pancreatic head adenocarcinoma. Surgery 2005, 138:618–630. Extended resection was associated with significantly longer operation and greater blood loss but did not appear to offer survival advantage. The study was underpowered (79 patients).

    Article  PubMed  Google Scholar 

  56. Berger AC, Watson JC, Ross EA, et al.: The metastatic/ examined lymph node ratio is an important prognostic factor after pancreaticoduodenectomy for pancreatic adenocarcinoma. Am Surg 2004, 70:235–240.

    PubMed  Google Scholar 

  57. Tanimura S, Higashino M, Fukunaga Y, et al.: Handassisted laparoscopic distal gastrectomy with regional lymph node dissection for gastric cancer. Surg Laparosc Endosc Percutan Tech 2001, 111:155–160.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Basil J. Ammori FRCS, MD.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ammori, B.J., Baghdadi, S. Minimally invasive pancreatic surgery: the new frontier?. Curr Gastroenterol Rep 8, 132–142 (2006). https://doi.org/10.1007/s11894-006-0009-5

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11894-006-0009-5

Keywords

Navigation