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Regulation of Cardiomyocyte Division During Cardiac Regeneration

  • Regenerative Medicine (SM Wu, Section Editor)
  • Published:
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Abstract

Purpose of Review

This review explores efforts made over the previous three decades to determine mechanisms of cardiomyocyte cell division. Many investigators have explored cell therapy strategies in animal models and clinical trials over the past 2 decades with marginal results thus far in clinical testing. Hence, there is a greater focus now on strategies to induce cardiomyocyte proliferation.

Recent Findings

Reports to induce reactivation of the cardiomyocyte cell cycle predated the focus on cell therapy, and we summarize the literature on this topic, which began with the very first transgenic mouse studies in cardiovascular science.

Summary

These earlier studies form the foundation for the use of cell cycle manipulation in cardiac repair and should inform current and future investigations with respect to rigor of assessment in the degree of cardiomyocyte cell division and gold standard measures of cardiac functional improvement.

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Data Availability

The data that support findings of this study are available from the corresponding author upon request.

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Funding

Hina W. Chaudhry has grant funding from NIH Grant: R01 HL150345 to fund some of the studies mentioned above and is an equity holder in VentriNova. She also has issued and pending patents pertaining to cyclin A2 for cardiac repair and the use of CDX2 cells for cardiac repair.

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Authors and Affiliations

  1. Division of Cardiology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Bingyan J. Wang

  2. Cardiovascular Regenerative Medicine, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, NY, USA

    Hina W. Chaudhry

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  1. Bingyan J. Wang
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Correspondence to Hina W. Chaudhry.

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Bingyan J. Wang reports no conflicts of interest.

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Wang, B.J., Chaudhry, H.W. Regulation of Cardiomyocyte Division During Cardiac Regeneration. Curr Cardiol Rep 25, 615–620 (2023). https://doi.org/10.1007/s11886-023-01886-7

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