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Therapeutic Options for In-Stent Restenosis

  • Ischemic Heart Disease (D Mukherjee, Section Editor)
  • Published:
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Abstract

Purpose of Review

In-stent restenosis (ISR) is a complex disease process that became apparent shortly after the introduction of stents into clinical practice. This review seeks to define in-stent restenosis (ISR) as well as to summarize the major treatment options that have been developed and studied over the past two decades.

Recent Findings

Recent developments in drug-coated balloons and bioresorbable vascular scaffolds have added new potential treatments for ISR. Two recent network meta-analyses performed a head-to-head comparison of all the various treatment modalities in order to identify the best approach to management of ISR.

Summary

Current data suggests that repeat stenting with second-generation drug-eluting stents is most likely to lead to the best angiographic and clinical outcomes. In situations where repeat stenting is not preferable, drug-coated balloon therapy seems to be a reasonably effective alternative.

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Papers of particular interest, published recently, have been highlighted as: •• Of major importance

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Authors and Affiliations

  1. Division of Cardiovascular Diseases, Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA

    Charles Nicolais, Vladimir Lakhter & Brian O’Murchu

  2. Division of Cardiovascular Diseases, Albert Einstein Health Center, Philadelphia, PA, USA

    Hafeez Ul Hassan Virk

  3. Division of Cardiovascular Diseases, University of Utah Health Sciences Center, Salt Lake City, UT, USA

    Partha Sardar

  4. Division of Cardiovascular Diseases, Mount Sinai St Luke’s-West Hospitals, New York, NY, USA

    Chirag Bavishi

  5. Division of Cardiovascular Diseases, St Francis Hospital-Hoffman Heart Center, Teaching affiliate, University of Connecticut School of Medicine, Farmington, CT, USA

    Saurav Chatterjee

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  1. Charles Nicolais
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Charles Nicolais, Vladimir Lakhter, Hafeez Ul Hassan Virk, Partha Sardar, Chirag Bavishi, Brian O’Murchu, and Saurav Chatterjee declare that they have no conflict of interest.

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Nicolais, C., Lakhter, V., Virk, H.U.H. et al. Therapeutic Options for In-Stent Restenosis. Curr Cardiol Rep 20, 7 (2018). https://doi.org/10.1007/s11886-018-0952-4

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