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Role of the Gut in Modulating Lipoprotein Metabolism

  • Lipid Abnormalities and Cardiovascular Prevention (G De Backer, Section Editor)
  • Published:
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Abstract

The intestinal production of lipoproteins is one of the key processes by which the body prepares dietary lipid for dissemination to locations throughout the body where they are required. Paramount to this is the relationship between dietary lipid and the enterocytes that line the gut, along with the processes which prepare this lipid for efficient uptake by these cells. These include those which occur in the mouth and stomach along with those which occur within the intestinal lumen itself. Additionally, the interplay between digested lipid, dual avenues for lipid uptake by enterocytes (passive and lipid transporter proteins), a system of intercellular lipid resynthesis and transport, and a complex system of lipoprotein synthesis yield a system open to significant modulation. In this review, we will attempt to outline the processes of lipid digestion, lipoprotein synthesis and the exogenous and endogenous factors which exert their influence.

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Alan A. Hennessy, R. Paul Ross, Gerald F. Fitzgerald, Noel Caplice, and Catherine Stanton declare that they have no conflict of interest.

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Authors and Affiliations

  1. Teagasc Food Research Centre, Moorepark, Fermoy, Co. Cork, Ireland

    Alan A. Hennessy, R. Paul Ross & Catherine Stanton

  2. Alimentary Pharmabiotic Centre, University College Cork, Co. Cork, Ireland

    Alan A. Hennessy, R. Paul Ross, Gerald F. Fitzgerald & Catherine Stanton

  3. Microbiology Department, University College Cork, Co. Cork, Ireland

    Gerald F. Fitzgerald

  4. Centre for Research in Vascular Biology, University College Cork, Co. Cork, Ireland

    Noel Caplice

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  1. Alan A. Hennessy
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  2. R. Paul Ross
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  3. Gerald F. Fitzgerald
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  5. Catherine Stanton
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Correspondence to Catherine Stanton.

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This article is part of the Topical Collection on Lipid Abnormalities and Cardiovascular Prevention

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Hennessy, A.A., Ross, R.P., Fitzgerald, G.F. et al. Role of the Gut in Modulating Lipoprotein Metabolism. Curr Cardiol Rep 16, 515 (2014). https://doi.org/10.1007/s11886-014-0515-2

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