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Role of HDL in Those with Diabetes

  • Diabetes and Cardiovascular Disease (S Malik, Section Editor)
  • Published:
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Abstract

Low levels of high-density lipoprotein cholesterol (HDL-C) have been associated with an increased risk of coronary heart disease in prospective population studies and clinical trials of high-risk patients treated with a low to moderate intensity statin. As a result, therapeutic targets were developed to increase concentrations of HDL-C. Subsequently, clinical trials of high-intensity statins have not supported this previously well-established association. In trials of high-intensity statin therapy, low HDL particle concentration (HDL-P) has been associated with an increased risk of future cardiovascular events. Therefore, strategies that increase HDL-C without expanding the pool of HDL-P with its rich proteome/lipidome do not seem to be an effective strategy. In this review, we discuss potential mechanisms of action for the anti-atherogenic effect of HDL and the impact of current and emerging therapies on the functional capacity of HDL-P. Finally, we discuss emerging therapies that increase the concentration and functional properties of HDL.

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Conflict of Interest

Carlos G. Santos-Gallego declares that he has no conflict of interest. Robert S. Rosenson has received grant/research support from Astra Zeneca, Amgen, Hoffman-LaRoche, Sanofi-Aventis. He has been a consultant/advisor for Abbott Labs, Aegerion, Amgen, Astra Zeneca, GSK Hoffman-LaRoche, Janssen, LipoScience, Novartis, Regeneron, Sanofi-Aventis. He has equity interests/stock options in LipoScience, Medicines Company. He has received honoraria from Kowa. He receives royalties from UpToDate, Inc.

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  1. Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, Box 1030, New York, NY, 10029, USA

    Carlos G. Santos-Gallego & Robert S. Rosenson

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  1. Carlos G. Santos-Gallego
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This article is part of the Topical Collection on Diabetes and Cardiovascular Disease

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Santos-Gallego, C.G., Rosenson, R.S. Role of HDL in Those with Diabetes. Curr Cardiol Rep 16, 512 (2014). https://doi.org/10.1007/s11886-014-0512-5

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