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Current Status of Stem Cell Therapy in Heart Failure

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Abstract

Inspired by studies demonstrating the potential for new myocyte formation within adult mammalian hearts, an ongoing explosion of research is elucidating the biology of cardiac myogenesis and angiogenesis. Multiple lines of research suggest that disease-associated activation of endogenous cardiac repair processes are often insufficient to overcome the cell death resulting from myocardial infarction and chronic heart failure. In this context, this review highlights current evidence supporting endogenous cardiac repair mechanisms in human hearts, recent progress with clinical application of myocardial cell therapy, and complementary efforts to manipulate endogenous myocardial repair processes using a variety of tissue engineering strategies. The goal of this overview is to demonstrate that the insights and opportunities derived from each of these lines of inquiry are mutually complementary for ultimately achieving the goal of therapeutic cardiac regeneration.

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Abbreviations

BALANCE:

Clinical Benefit and Long-Term Outcome After Intracoronary Autologous Bone Marrow Cell Transplantation in Patients With Acute Myocardial Infarction

BOOST:

Bone Marrow Transfer to Enhance ST-Elevation Infarct Regeneration

CADUCEUS:

Cardiosphere-Derived Autologous Stem Cells to Reverse Ventricular Dysfunction

FIRSTLINE-AMI:

Front-Integrated Revascularization and Stem Cell Liberation in Evolving Acute Myocardial Infarction by Granulocyte Colony-Stimulating Factor

MAGIC:

Myoblast Autologous Grafting in Ischemic Cardiomyopathy

MARVEL-1:

To Assess Safety and Efficacy of Myoblast Implantation Into Myocardium Post Myocardial Infarction-1

MYSTAR:

Myocardial Stem Cell Administration After Acute Myocardial Infarction

PROMETHEUS:

Prospective Randomized Assessment Of Mesenchymal Stem Cell Therapy in Patients Undergoing Surgery

REPAIR-AMI:

Reinfusion of Enriched Progenitor Cells and Infarct Remodeling in Acute Myocardial Infarction

REVIVAL-2:

Bone Marrow Stem Cell Mobilisation Therapy for Acute Myocardial Infarction

SCIPIO:

Myocardial Regeneration Using Cardiac Stem Cells

STEMMI:

Stem Cells in Myocardial Infarction

TAC-HFT:

Transendocardial Autologous Cells in Heart Failure Trial

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Disclosure

The authors acknowledge the National Institutes of Health (for R01 HL089847 to K.B.M), the Southeastern Pennsylvania Affiliate of the American Heart Association (for a predoctoral fellowship to J.E.), and The American Heart Association-Jon Holden DeHaan Foundation Cardiac Myogenesis Research Center Program (for support of M.C. and K.B.M.).

No other potential conflicts of interest relevant to this article were reported.

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  1. University of Pennsylvania School of Medicine, BRB II/III, Room 608, 421 Curie Boulevard, Philadelphia, PA, 19014, USA

    Marta Codina, Jeremy Elser & Kenneth B. Margulies

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  1. Marta Codina
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Correspondence to Kenneth B. Margulies.

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Codina, M., Elser, J. & Margulies, K.B. Current Status of Stem Cell Therapy in Heart Failure. Curr Cardiol Rep 12, 199–208 (2010). https://doi.org/10.1007/s11886-010-0098-5

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