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N-3 Fatty Acids for Prevention of Cardiovascular Disease

  • Clinical Trials and Their Interpretations (JR Kizer, Section Editor)
  • Published:
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Abstract

Cardiovascular disease (CVD) is the leading cause of death in the USA. A diet enriched with n-3 fatty acids (FA) has been reported to play an important role in preventing the development of CVD. Prior studies have demonstrated beneficial effects of n-3 FA on hypertriglyceridemia, blood pressure, inflammation, endothelial function, and platelet function. However, data on the relation of n-3 FA consumption with CVD risk remain inconsistent. This paper reviews current evidence on the effects of n-3 FA on CVD, CVD risk factors, and potential biologic mechanisms. Last, we discuss major limitations of currently available data and future directions in the field.

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Conflict of Interest

Owais Khawaja, John M Gaziano, and Luc Djoussé declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Correspondence to Luc Djoussé.

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This article is part of the Topical Collection on Clinical Trials and Their Interpretations

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Khawaja, O.A., Gaziano, J.M. & Djoussé, L. N-3 Fatty Acids for Prevention of Cardiovascular Disease. Curr Atheroscler Rep 16, 450 (2014). https://doi.org/10.1007/s11883-014-0450-0

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  • DOI: https://doi.org/10.1007/s11883-014-0450-0

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