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Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia

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Abstract

Objectives

This study investigates the roles of HIF-2α, hepcidin, and ghrelin in iron deficiency anemia (IDA), the most widespread nutritional disorder globally.

Material and methods

Fifty IDA patients (18–50 years, BMI 19–25) and 40 healthy volunteers were studied. Hemoglobin, ferritin, hepcidin, HIF-2α, and ghrelin levels were analyzed.

Results

IDA patients showed lower hemoglobin, ferritin, hepcidin, and ghrelin levels than the control group, but HIF-2α levels were similar. Positive correlations were observed in both groups between hepcidin and HIF-2α (p < 0.001), hepcidin and ghrelin (p < 0.001), and HIF-2α and ghrelin (p < 0.001). Hemoglobin was correlated positively with HIF-2α, and ferritin was correlated positively with HIF-2α in the patient group.

Conclusion

The study suggests that the low hepcidin levels in IDA patients enhance iron absorption. The lack of significant HIF-2α level differences may be due to the absence of chronic hypoxia in current hemoglobin levels of IDA patients. Moreover, the low ghrelin levels in patients and the correlations between ghrelin, hepcidin, and HIF-2α in both groups indicate their involvement in iron metabolism.

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Funding

A grant was received from Antalya Training and Research Hospital scientific research project for the article.

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Authors and Affiliations

  1. Antalya Training and Research Hospital, Internal Medicine Clinic, Antalya Eğitim ve Araştırma Hastanesi, Varlık Mh. Kazım Karabekir Cd. 07100, Antalya, Turkey

    Esra Rizaogullari Guzel

  2. Antalya Training and Research Hospital, Biochemistry Clinic, Antalya, Turkey

    Nihan Cansel Sarkaya & Ayşegul Ugur Kurtoglu

  3. Antalya Training and Research Hospital, Hematology Clinic, Antalya, Turkey

    Volkan Karakus & Erdal Kurtoglu

Authors
  1. Esra Rizaogullari Guzel
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  2. Nihan Cansel Sarkaya
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  3. Ayşegul Ugur Kurtoglu
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  4. Volkan Karakus
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  5. Erdal Kurtoglu
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Correspondence to Esra Rizaogullari Guzel.

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Guzel, E.R., Sarkaya, N.C., Kurtoglu, A.U. et al. Roles of ghrelin, hepcidin and HIF-2α in iron metabolism in iron deficiency anemia. Ir J Med Sci (2024). https://doi.org/10.1007/s11845-024-03655-z

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  • DOI: https://doi.org/10.1007/s11845-024-03655-z

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