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Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus

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Abstract

Introduction

It is necessary to assay multiple autoantibodies simultaneously in the same group of new-onset systemic lupus erythematosus (SLE) patient.

Aim

To determine the prevalence and clinical significance of 15 autoantibodies in patients with new-onset SLE.

Methods

Twenty new-onset patients with SLE and 32 healthy individuals were enrolled in the present study. Serum levels of 15 autoantibodies were detected by enzyme linked immunosorbent assay. The clinical parameters of the patients were also recorded.

Results

The positive rate of anti-ssDNA was the highest (85%). The positive rates of anti-dsDNA, anti-ssDNA, AHA, anti-SSA, anti-SSB, anti-Sm, anti-U1RNP, AnuA, and rRNP were significantly higher in SLE patients than in nomal controls. In terms of clinical manifestation, there were significant associations of rRNP with photaesthesia and of AHA with nephritis.

Conclusion

Clusters of autoantibodies were identified and associations of antibodies with symptoms were found in new-onset patients with SLE.

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Acknowledgments

This work was supported by grants from the National Natural Science Foundation of China (30771848), the key program of National Natural Science Foundation of China (30830089) and the Specialized Research Fund for Doctoral Program of Higher Education of China (20070366002).

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Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China

    W.-X. Li, H.-F. Pan, L.-H. Li, N. Zhang, J. Li, Y.-G. Fan, J.-B. Feng, X.-W. Tang, H. Chen & D.-Q. Ye

  2. Department of Rheumatology, Anhui Provincial Hospital, Hefei, China

    X.-P. Li

Authors
  1. W.-X. Li
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  2. H.-F. Pan
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  3. L.-H. Li
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  4. N. Zhang
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  5. J. Li
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  6. Y.-G. Fan
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  7. J.-B. Feng
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  8. X.-W. Tang
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  9. H. Chen
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  10. X.-P. Li
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  11. D.-Q. Ye
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Corresponding author

Correspondence to D.-Q. Ye.

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Li, WX., Pan, HF., Li, LH. et al. Prevalence and clinical significance of 15 autoantibodies in patients with new-onset systemic lupus erythematosus. Ir J Med Sci 179, 623–627 (2010). https://doi.org/10.1007/s11845-010-0543-x

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  • DOI: https://doi.org/10.1007/s11845-010-0543-x

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