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Surface Modifications of Titanium Implants by Multilayer Bioactive Coatings with Drug Delivery Potential: Antimicrobial, Biological, and Drug Release Studies

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Abstract

Recent strategies to locally deliver antimicrobial agents to combat implant-associated infections—one of the most common complications in orthopedic surgery—are gaining interest. However, achieving a controlled release profile over a desired time frame remains a challenge. In this study, we present an innovative multifactorial approach to combat infections which comprises a multilayer chitosan/bioactive glass/vancomycin nanocomposite coating with an osteoblastic potential and a drug delivery capacity. The bioactive drug-eluting coating was prepared on the surface of titanium foils by a multistep electrophoretic deposition technique. The adopted deposition strategy allowed for a high antibiotic loading of 1038.4 ± 40.2 µg/cm2. The nanocomposite coating exhibited a suppressed burst release with a prolonged sustained vancomycin release for up to 6 weeks. Importantly, the drug release profile was linear with respect to time, indicating a zero-order release kinetics. An in vitro bactericidal assay against Staphylococcus aureus confirmed that releasing the drug reduced the risk of bacterial infection. Excellent biocompatibility of the developed coating was also demonstrated by in vitro cell studies with a model MG-63 osteoblast cell line.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Sharif University of Technology, Azadi Avenue, P.O. Box 11365-9466, Tehran, Iran

    Farideh Ordikhani & Abdolreza Simchi

  2. Department of Biomedical Engineering, Saint Louis University, 3507 Lindell Blvd, Saint Louis, MO, USA

    Silviya Petrova Zustiak

  3. Institute for Nanoscience and Nanotechnology, Sharif University of Technology, Azadi Avenue, P.O. Box 11365-9466, Tehran, Iran

    Abdolreza Simchi

Authors
  1. Farideh Ordikhani
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  2. Silviya Petrova Zustiak
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  3. Abdolreza Simchi
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Correspondence to Silviya Petrova Zustiak or Abdolreza Simchi.

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Ordikhani, F., Zustiak, S.P. & Simchi, A. Surface Modifications of Titanium Implants by Multilayer Bioactive Coatings with Drug Delivery Potential: Antimicrobial, Biological, and Drug Release Studies. JOM 68, 1100–1108 (2016). https://doi.org/10.1007/s11837-016-1840-2

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