Abstract
A simple, regioselective, environmentally clean and economical method for the preparation of side chain/ ring brominated aromatic compounds is reported in 70–98% yield by an electrochemical method using two phase electrolysis technique. Electrochemical reactions were carried out using aqueous 25–50 wt% sodium bromide containing catalytic amount (5 wt%) of hydrobromic acid as an aqueous phase and chloroform containing alkyl aromatic compounds as an organic phase, at a temperature of 0–30 °C in an undivided cell. The same two-phase electrolytic system can be used for the oxidation of benzylic alcohols to the corresponding benzaldehydes in 80–94% yield without over oxidation to carboxylic acids. The advantage of this very mild procedure is a room temperature reaction used with an undivided cell. Excellent conversions are observed. After completion of alcohol oxidation the electrolyte can be reused for a number of times, demonstrating “spent reagent” free electro organic reaction as an attractive one. In the case of side chain/ring bromination of alkyl aromatic compounds, the electrolyte can be reused after making up the concentration of the electrolyte with 47 wt% HBr solution. In some cases homogeneous electrolysis is applied, where the two-phase electrolysis did not work. Styrene epoxidation and α-bromination of ketones underwent homogeneous electrolysis at room temperature without any catalyst. The reaction was performed in CH3CN-water (3: 2) using equimolar amount of NaBr as an electrolyte to get 68% of styrene epoxide. Use of an ionic liquid 1-butyl 3-methyl imidazolium bromide (Bmim) Br, instead of NaBr improved the yield and current efficiency of styrene epoxide to 86%.
Similar content being viewed by others
References
T.M. Shaikh and A. Sudalai Tetrahedron Lett., 46, 5587 (2005).
M. Eissen and D. Lenoir, Chem. Eng. J., 14, 9830 (2008).
A. Chakradhar, R. Roopa, K. C. Rajanna and P.K. Saiprakash, Synth. Commun., 39, 1817 (2009).
R. Mestres and J. Palenzuela Green Chem., 4, 314 (2003).
J. B. Sperry and D. L. Wright, Chem. Soc. Rev., 35, 605 (2006).
J. Yoshida, K. Kataoka, R. Horcajada and A. Nagaki Chem. Rev., 108, 2265 (2008).
S. Suga, K. Matsumoto, K. Ueoka and J. Yoshida J. Am. Chem. Soc., 128, 7710 (2006).
S.R. Forsyth and D. Pletcher, Extended abstracts of Ist International Symposium on Electro organic synthesis, Kurashiki, 35 (1986).
H. Fees, H. Wendt, J. Chem. Technol. Biotechnol., 30, 297 (1980).
M. Morita, S. Yamamoto and Y. Matsuda, J. Appl. Electrochem., 18, 49 (1988).
T. Raju, K. Kulangiappar, K. Shankar and M. Anbu Kulandai Electrochim. Acta, 51, 356 (2005).
A. Muthukumaran, T. Raju and V. Krishnan, Bull. Electrochem., 9, 630 (1993).
M. Anbu Kulandainathan, K. Kulangiappar, M. Elangovan, S. Govindu, T. Raju and V. Krishnan, Bull. Electrochem., 16, 392 (2000).
T. Raju, K. Kulangiappar, M. Anbu Kulandainathan, M. Revathy, U. Uma and A. Malini, Tetrahedron Lett., 47, 4581 (2006).
T. Ogamino, K. Mori, S. Yamamura and S. Nishiyama, Electrochim. Acta, 49, 4865 (2004).
K. Rossen, R. P. Volante and P. J. Reider Tetrahedron Lett., 38, 777 (1997).
N. H. Jonathan, A. Ahmed and H. S. Rodney, US Patent, 5,385,650. Jan 31 (1995).
T. Raju, K. Kulangiappar and M. Anbu Kulandainathan, Tetrahedron Lett., 46, 7047 (2005).
K. Kulangiappar, G. Karthick and M. Anbu Kulandainathan, Synth. Commun., 39, 2304 (2010).
Ullman’s encyclopedia of Industrial chemistry, 6th Ed., Wiley-VCH, Weinheim Electronic Release (1998).
A. Butler and J. V. Walker, Chem. Rev., 93, 1937 (1993).
M. Hudluchy, Oxidations in organic chemistry, ACS Monograph series, American Chemical society Washington, DC (1990).
S. S. Stahl, Angew. Chem., Int. Ed., 43, 3400 (2004).
G. Cainelli and G. Cardillo, Chromium oxidants in organic chemistry, Springer, Berlin (1984).
M. Musawir, P. N. Davey, G. Kelly and I.V. Kozhevnikov Chem. Commun., 14, 14 (2003).
R. E.W. Jansson and N. R. Tomov J. Appl. Electrochem., 10, 583 (1980).
Y. Shimizu, K. Mitsudo and H. Tanaka, Tetrahedron Lett., 46, 8975 (2005).
B. S. Koo, C. K. Lee and K. J. Lee, Synth. Commun., 32, 2115 (2002).
T. Yoshida, M. Okimoto and M. Hoshi, Synth. Commun., 41, 3134 (2011).
M. C. Jose, M. T. Molina and A. Shazia, Chem. Rev., 104, 2857 (2004).
B. S. Lane and K. Burgess, Chem. Rev., 103, 2457 (2003).
I. Sakia, B. Kashyap and P. Phukan, Synth. Commun., 40, 2647 (2010).
T. Raju and K. Kulangiappar, Unpublished results.
I. Massuquinini, J. M. Antunio, P. Ana, D. I. Esteves and J. M. Maria, Comptes Rendus Chimie., 841 (2009).
T. Raju and K. Kulangiappar, Unpublished results.
A. M. Erian, S. M. Sherif and H. M. Gaber, Molecules., 8, 793 (2003).
C. Giodano, G. Castaldi and C. Giordano, JP92054657 — B2 (1992).
L. C. King and G. K. Ostrum, J. Org. Chem., 29, 3459 (1964).
A. T. Khan, P. Goswami and L.H. Choudhury, Tetrahedron Lett., 47, 2751 (2006).
K. Tanemura, T. Suzuki, Y. Nishida, K. Satsumabayashi and T. Horaguchi, Chem. Lett., 32, 932 (2003).
S. Kajigaeshi, T, Kakinami, T. Okamoto and S. Fujisaki, Bull. Chem. Soc. Jpn., 60, 1159 (1987).
R. Senthil Kumar, K. Kulangiappar and M. Anbu Kulandainathan, Synth. Commun., 40, 1736 (2010).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Thasan, R., Kumarasamy, K. Electrochemical bromination and oxidation of alkyl aromatic compounds by two-phase electrolysis. Korean J. Chem. Eng. 31, 365–373 (2014). https://doi.org/10.1007/s11814-014-0012-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11814-014-0012-8