Skip to main content
SpringerLink
Log in

Side effects during treatment of advanced gastric carcinoma by chemotherapy combined with CIK-cell transfusion in elderly people

  • Published:
Chinese Journal of Clinical Oncology

Abstract

Objective

To study the side effects and therapeutic results of autologous cytokine-induced killer (CIK) cell treatment in elderly patients with advanced gastric cancer.

Methods

CIK cells were induced and cultured using biotechnics in vitro, and then the cells were infused back into the patients. Sixty elderly gastric cancer patients treated by chemotherapy (FOLFOX4 protocol) were followed-up. Among them, 29 patients were treated with CIK cells during application of chemotherapy. Short-term curative effects and adverse events from the CIK transfusion and chemotherapy were observed.

Results

Eight cases developed partial remission (PR), 9 cases moderate remission (MR), 7 cases stable disease (SD) and 5 cases progressive disease (PD). Out of a total of 29 patients who received chemotherapy combined with autologous CIK therapy, the total remission rate (PR + MR) was 58.6%. The total remission rate following chemotherapy alone was 45.2%, including 5 PR cases, 9 MR cases, 7 SD cases, and 10 PD cases. There was a relatively lower rate of severe chemotherapic toxicities in the CIK-cell transfusion group. Side effects of autologous CIK transfusion included chills (13 cases), fever (9 cases), nausea and vomiting (1 case) and general malaise (3 cases). Side effects were treated with conventional therapy resulting in their amelioration. No patients developed shock, blood capillary leakage syndrome, or abnormalities in routine blood, urine, liver and renal function tests.

Conclusion

Adoptive immunotherapy with autologous CIK cells may decrease the clinical signs and symptoms of elderly patients who suffer from advanced gastric cancer. Adverse reactions of patients can be alleviated by conventional therapy. Autologous CIK-cell transfusion may improve endurance to chemotherapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Gallo A and Cha C. Updates on esophageal and gastric cancers. World J Gastroenterol 2006; 12: 3237–3242.

    PubMed  Google Scholar 

  2. Chen FX, Liu JQ, Zhang NZ, et al. Clinical observation on adoptive immunotherapy with autologous cytokine-induced killer cells for advanced malignant tumor. Ai Zheng 2002; 21: 797–801 (Chinese).

    PubMed  Google Scholar 

  3. Chen L, Tian H, Chen J, et al. Surgical management of gastric stump cancer: a report of 37 cases. J Zhejiang Univ Sci B 2005; 6: 38–42.

    Article  PubMed  Google Scholar 

  4. Abe M, Nishimura Y, Shibamoto Y. Intraoperative radiation therapy for gastric cancer. World J Surg 1995; 19: 544–547.

    PubMed  CAS  Google Scholar 

  5. Bresciani C, Gama-Rodrigues J, Strassmann V, et al. Long term (five-year) survival following radical surgical treatment plus adjuvant chemotherapy (FAM) in advanced gastric cancer: a controlled study. Rev Hosp Clin Fac Med Sao Paulo 2000; 55: 129–136.

    PubMed  CAS  Google Scholar 

  6. Jiang J, Xu N, Wu C, et al. Treatment of advanced gastric cancer by chemotherapy combined with autologous cytokine-induced killer cells. Anticancer Res 2006; 26: 2237–2242.

    PubMed  CAS  Google Scholar 

  7. Jiang J, Wu C, Chen X, et al. Analysis of the therapeutic effect of tumour infiltrating lymphocytes on malignant pleural effusion in aged. Chin J Geriatrics. 1999; 18: 35–37 (Chinese).

    CAS  Google Scholar 

  8. Schmidt-Wolf GD, Negrin RS, Schmidt-Wolf IG. Activated T cells and cytokine-induced CD3+CD56+ killer cells. Ann Hematol 1997; 74: 51–56.

    Article  PubMed  CAS  Google Scholar 

  9. Kollmannsberger C, Budach W, Stahl M, et al. Adjuvant chemoradiation using 5-fluorouracil/folinic acid/cisplatin with or without paclitaxel and radiation in patients with completely resected high-risk gastric cancer: two cooperative phase II studies of the AIO/ARO/ACO. Ann Oncol 2005; 16: 1326–1333.

    Article  PubMed  CAS  Google Scholar 

  10. Lin WL, Li DG, Chen Q, et al. Clinical and experimental study of oxaliplatin in treating human gastric carcinoma. World J Gastroenterol 2004; 10: 2911–2915.

    PubMed  CAS  Google Scholar 

  11. Klautke G, Foitzik T, Ludwig K, et al. Neoadjuvant radiochemotherapy in locally advanced gastric carcinoma. Strahlenther Onkol 2004;180: 695–700.

    Article  PubMed  Google Scholar 

  12. Zuo Y, Xu M, Shen D, et al. Postoperative intraperitioneal hyperthermic chemoperfusion combined with intravenous chemotherapy for 82 advanced gastric cancer patients. Chin J Oncol 2004; 26: 247–249 (Chinese).

    Google Scholar 

  13. Bozzetti F, Vaglini M, Deraco M. Intraperitoneal hyperthermic chemotherapy in gastric cancer: rationale for a new approach. Tumori 1998; 84: 483–488.

    PubMed  CAS  Google Scholar 

  14. Yu QS, Zhang FZ, Tang XR. Clinical study on early use of Chinese medicinal herbs and chemotherapy after operation of gastric cancer. Zhongguo Zhong Xi Yi Jie He Za Zhi 1995; 15: 459–461 (Chinese).

    PubMed  CAS  Google Scholar 

  15. Wang GT. Treatment of operated late gastric carcinoma with prescription of strengthening the patient’s resistance and dispelling the invading evil in combination with chemotherapy: follow-up study of 158 patients and experimental study in animals. Zhong Xi Yi Jie He Za Zhi 1990; 10: 712–716, 707 (Chinese).

    PubMed  CAS  Google Scholar 

  16. Catalano V, Labianca R, Beretta GD, et al. Gastric cancer. Crit Rev Oncol Hematol 2005; 54: 209–241.

    Article  PubMed  Google Scholar 

  17. Herberman RB. Cancer therapy by biological response modifiers. Clin Physiol Biochem 1987; 5: 238–248.

    PubMed  CAS  Google Scholar 

  18. Margolin KA, Negrin RS, Wong KK, et al. Cellular immunotherapy and autologous transplantation for hematologic malignancy. Immunol Rev 1997; 157: 231–240.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Tumor Biological Treatment, Third Affiliated Hospital, Suzhou University, Changzhou, 213003, Jiangsu province, China

    Jingting Jiang, Changping Wu, Liangrong Shi, Haifeng Deng, Mingyang Lu & Mei Ji

  2. Section of Clinical Chemistry & Pharmacology, Lund University, S-221 85, Lund, Sweden

    Ning Xu

  3. Institute of Biotechnology, Key Laboratory of Clinical Immunology of Jiangsu Province, Suzhou University, Suzhou, 215007, Jiangsu province, China

    Yibei Zhu & Xueguang Zhang

Authors
  1. Jingting Jiang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Changping Wu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Liangrong Shi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ning Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Haifeng Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Mingyang Lu
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Mei Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Yibei Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Xueguang Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Changping Wu.

About this article

Cite this article

Jiang, J., Wu, C., Shi, L. et al. Side effects during treatment of advanced gastric carcinoma by chemotherapy combined with CIK-cell transfusion in elderly people. Chin. J. Clin. Oncol. 5, 79–82 (2008). https://doi.org/10.1007/s11805-008-0079-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11805-008-0079-2

Key Words

Search

Navigation