Skip to main content
Log in

Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical wastewater

  • Research Article
  • Published:
Frontiers of Environmental Science & Engineering Aims and scope Submit manuscript

Abstract

Treatment of sulfamethoxazole pharmaceutical wastewater is a big challenge. In this study, a series of anaerobic evaluation tests on pharmaceutical wastewater from different operating units was conducted to evaluate the feasibility of using anaerobic digestion, and the results indicated that the key refractory factor for anaerobic treatment of this wastewater was the high sulfate concentration. A laboratory-scale up-flow anaerobic sludge blanket (UASB) reactor was operated for 195 days to investigate the effects of the influent chemical oxygen demand (COD), organic loading rate (OLR), and COD/SO2–4 ratio on the biodegradation of sulfamethoxazole in pharmaceutical wastewater and the process performance. The electron flow indicated that methanogenesis was still the dominant reaction although sulfidogenesis was enhanced with a stepwise decrease in the influent COD/SO2–4 ratio. For the treated sulfamethoxazole pharmaceutical wastewater, a COD of 4983 mg/L (diluted by 50%), OLR of 2.5 kg COD/(m3∙d), and COD/SO2–4 ratio of more than 5 were suitable for practical applications. The recovery performance indicated that the system could resume operation quickly even if production was halted for a few days.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • APHA (2005). Standard methods for the examination of water and wastewater. American Water Works Association/American Public Works Association/Water Environment Federation, 21st ed. American Public Health Association, Washington DC, USA

    Google Scholar 

  • Aydin S, Ince B, Cetecioglu Z, Arikan O, Ozbayram E G, Shahi A, Ince O (2015). Combined effect of erythromycin, tetracycline and sulfamethoxazole on performance of anaerobic sequencing batch reactors. Bioresource Technology, 186(3): 207–214

    Article  CAS  Google Scholar 

  • Cetecioglu Z, Ince B, Gros M, Rodriguez-Mozaz S, Barceló D, Ince O, Orhon D (2015). Biodegradation and reversible inhibitory impact of sulfamethoxazole on the utilization of volatile fatty acids during anaerobic treatment of pharmaceutical industry wastewater. Science of the Total Environment, 536(7): 667–674

    Article  CAS  Google Scholar 

  • Cetecioglu Z, Ince B, Orhon D, Ince O (2016). Anaerobic sulfamethoxazole degradation is driven by homoacetogenesis coupled with hydrogenotrophic methanogenesis. Water Research, 90(12): 79–89

    Article  CAS  Google Scholar 

  • Chen Q Q, Wu W D, Zhang Z Z, Xu J J, Jin R C (2017). Inhibitory effects of sulfamethoxazole on denitrifying granule properties: Shortand long-term tests. Bioresource Technology, 233(2): 391–398

    Article  CAS  Google Scholar 

  • Chen Z, Wang H, Chen Z, Ren N, Wang A, Shi Y, Li X (2011). Performance and model of a full-scale up-flow anaerobic sludge blanket (UASB) to treat the pharmaceutical wastewater containing 6-APA and amoxicillin. Journal of Hazardous Materials, 185(2–3): 905–913

    Article  CAS  Google Scholar 

  • Das B K, Roy S, Dev S, Das D, Bhattacharya J (2015). Improvement of the degradation of sulfate rich wastewater using sweetmeat waste (SMW) as nutrient supplement. Journal of Hazardous Materials, 300 (8): 796–807

    Article  CAS  Google Scholar 

  • Hoa T T H, Liamleam W, Annachhatre A P (2007). Lead removal through biological sulfate reduction process. Bioresource Technology, 98(13): 2538–2548

    Article  CAS  Google Scholar 

  • Hu Y, Jing Z, Sudo Y, Niu Q, Du J, Wu J, Li Y Y (2015). Effect of influent COD/SO4 2‒ratios on UASB treatment of a synthetic sulfatecontaining wastewater. Chemosphere, 130(2): 24–33

    Article  CAS  Google Scholar 

  • Isa Z, Grusenmeyer S, Verstraete W (1986). Sulfate reduction relative to methane production in high-rate anaerobic digestion: microbiological aspects. Applied and Environmental Microbiology, 51(3): 580–587

    CAS  Google Scholar 

  • Jeong T Y, Chung H K, Yeom S H, Choi S S (2009). Analysis of methane production inhibition for treatment of sewage sludge containing sulfate using an anaerobic continuous degradation process. Korean Journal of Chemical Engineering, 26(5): 1319–1322

    Article  CAS  Google Scholar 

  • Jia Y, Khanal S K, Zhang H, Chen G H, Lu H (2017). Sulfamethoxazole degradation in anaerobic sulfate-reducing bacteria sludge system. Water Research, 119(4): 12–20

    Article  CAS  Google Scholar 

  • Jing Z, Hu Y, Niu Q, Liu Y, Li Y Y, Wang X C (2013). UASB performance and electron competition between methane-producing archaea and sulfate-reducing bacteria in treating sulfate-rich wastewater containing ethanol and acetate. Bioresource Technology, 137 (11): 349–357

    Article  CAS  Google Scholar 

  • Kaksonen A H, Puhakka J A (2007). Sulfate reduction based bioprocesses for the treatment of acid mine drainage and the recovery of metals. Engineering in Life Sciences, 7(6): 541–564

    Article  CAS  Google Scholar 

  • Kiyuna L S M, Fuess L T, Zaiat M (2017). Unraveling the influence of the COD/sulfate ratio on organic matter removal and methane production from the biodigestion of sugarcane vinasse. Bioresource Technology, 232(2): 103–112

    Article  CAS  Google Scholar 

  • Li W, Niu Q, Hong Z, Zhe T, Yu Z, Gao Y, Li Y Y, Nishimura O, Min Y (2015). UASB treatment of chemical synthesis-based pharmaceutical wastewater containing rich organic sulfur compounds and sulfate and associated microbial characteristics. Chemical Engineering Journal, 260(8): 55–63

    CAS  Google Scholar 

  • Li Y, Hu Q, Chen C H, Wang X L, Gao D W (2017). Performance and microbial community structure in an integrated anaerobic fluidizedbed membrane bioreactor treating synthetic benzothiazole contaminated wastewater. Bioresource Technology, 236(3): 1–10

    CAS  Google Scholar 

  • Liu Z H, Maszenan A M, Liu Y, Ng W J (2015). A brief review on possible approaches towards controlling sulfate-reducing bacteria (SRB) in wastewater treatment systems. Desalination and Water Treatment, 53(10): 2799–2807

    Article  CAS  Google Scholar 

  • Lu X, Zhen G, Ni J, Hojo T, Kubota K, Li Y Y (2016). Effect of influent COD/SO 2‒4 ratios on biodegradation behaviors of starch wastewater in an upflow anaerobic sludge blanket (UASB) reactor. Bioresource Technology, 214(4): 175–183

    Article  CAS  Google Scholar 

  • Mizuno O, Li Y Y, Noike T (1994). Effects of sulfate concentration and sludge retention time on the interaction between methane production and sulfate reduction for butyrate. Water Science and Technology, 30 (8): 45–54

    Article  CAS  Google Scholar 

  • Sabumon P C (2008). Development of enhanced sulphidogenesis process for the treatment of wastewater having low COD/SO4 2‒ratio. Journal of Hazardous Materials, 159(2–3): 616–625

    Article  CAS  Google Scholar 

  • Shin H S, Oh S E, Lee C Y (1997). Influence of sulfur compounds and heavy metals on the methanization of tannery wastewater. Water Science and Technology, 35(8): 239–245

    Article  CAS  Google Scholar 

  • Sponza D T, Demirden P (2007). Treatability of sulfamerazine in sequential upflow anaerobic sludge blanket reactor (UASB)/completely stirred tank reactor (CSTR) processes. Separation and Purification Technology, 56(1): 108–117

    Article  CAS  Google Scholar 

  • Svojitka J, Dvořák L, Studer M, Straub J O, Frömelt H, Wintgens T (2017). Performance of an anaerobic membrane bioreactor for pharmaceutical wastewater treatment. Bioresource Technology, 229 (1): 180–189

    Article  CAS  Google Scholar 

  • Tursman J F, Cork D (1989). Influence of sulfate and sulfate-reducing bacteria on anaerobic digestion technology. Advances in Biotechnological Processes, 12(1): 273–285

    CAS  Google Scholar 

  • Vallero M V G, Lettinga G, Lens P N L (2005). High rate sulfate reduction in a submerged anaerobic membrane bioreactor (SAMBaR) at high salinity. Journal of Membrane Science, 253(1–2): 217–232

    Article  CAS  Google Scholar 

  • Weijma J, Stams A J, Hulshoff Pol L W, Lettinga G (2000). Thermophilic sulfate reduction and methanogenesis with methanol in a high rate anaerobic reactor. Biotechnology and Bioengineering, 67(3): 354–363

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This study was supported by the Fundamental Research Funds for the Central Universities (No. 2015XKMS053).

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Shilong He or Yingxin Gao.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chen, Y., He, S., Zhou, M. et al. Feasibility assessment of up-flow anaerobic sludge blanket treatment of sulfamethoxazole pharmaceutical wastewater. Front. Environ. Sci. Eng. 12, 13 (2018). https://doi.org/10.1007/s11783-018-1069-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • DOI: https://doi.org/10.1007/s11783-018-1069-0

Keywords

Navigation