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Clinicopathological features of intraoperative pleural lavage cytology for non-small cell lung cancer

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Abstract

Objective

The significance of clinicopathological features of pre- and post-resection pleural lavage cytology (PLC) for non-small cell lung carcinoma (NSCLC) currently remains unknown.

Methods

Between January 2010 and December 2012, pre- and post-resection PLC were performed for NSCLC in 565 patients at Tohoku University, Miyagi Cancer Center, or Sendai Medical Center. The relationship between the clinicopathological features and patient outcomes was analyzed.

Results

Twenty-two patients (3.9%) had positive findings from pre- or post-resection PLC. Both PLC were correlated with pT and pl factors, while only post-resection PLC was correlated with pN factor (p < 0.005). The 5-year disease-free survival (DFS) rate of the positive pre-resection PLC was significantly poorer than that of negative (26.7% vs. 76.9%, p < 0.0001). In addition, the 5-year DFS of the positive post-resection PLC was also poorer than that of negative (14.3% vs. 76.0%, p < 0.0001). Multivariate analyses revealed that both PLC were not independent prognostic factors in our study.

Conclusions

A significant association of post-resection PLC with N factor is considered to be characteristics of post-resection PLC different from pre-resection PLC. A prognostic impact of post-resection PLC and its detailed difference from pre-resection PLC should be clarified by further investigations.

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Authors and Affiliations

  1. Department of Thoracic Surgery, Sendai Medical Center, Sendai, 983-8520, Japan

    Ken Onodera, Tohru Hasumi & Yasuki Saito

  2. Department of Thoracic Surgery, Institute of Development, Aging and Cancer, Tohoku University, Seiryo-machi 4-1, Aoba-ku, Sendai, 980-8575, Japan

    Akira Sakurada, Fumihiko Hoshi & Yoshinori Okada

  3. Department of Thoracic Surgery, Miyagi Cancer Center, Natori, 981-1293, Japan

    Jiro Abe & Satomi Takahashi

Authors
  1. Ken Onodera
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  2. Akira Sakurada
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  3. Fumihiko Hoshi
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  4. Jiro Abe
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  5. Tohru Hasumi
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  6. Satomi Takahashi
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  7. Yasuki Saito
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  8. Yoshinori Okada
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Correspondence to Akira Sakurada.

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The authors declare no conflicts of interest in association with the present study.

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Onodera, K., Sakurada, A., Hoshi, F. et al. Clinicopathological features of intraoperative pleural lavage cytology for non-small cell lung cancer. Gen Thorac Cardiovasc Surg 68, 164–169 (2020). https://doi.org/10.1007/s11748-019-01170-y

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  • DOI: https://doi.org/10.1007/s11748-019-01170-y

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