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Randomized trial of two after-dialysis gabapentin regimens for severe uremic pruritus in hemodialysis patients

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References

  1. Schena FP (2011) Management of patients with chronic kidney disease. Intern Emerg Med 6(Suppl 1):77–83

    Article  Google Scholar 

  2. Simonsen E, Komenda P, Lerner B et al (2017) Treatment of uremic pruritus: a systematic review. Am J Kidney Dis 70(5):638–655

    Article  CAS  Google Scholar 

  3. Stander S, Weisshaar E, Mettang T et al (2007) Clinical classification of itch: a position paper of the International Forum for the Study of Itch. Acta Derm Venereol 87(4):291–294

    Article  Google Scholar 

  4. Casino FG, Lopez T (1996) The equivalent renal urea clearance: a new parameter to assess dialysis dose. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 11(8):1574–1581

    CAS  Google Scholar 

  5. Friedman LM, Furberg C, DeMets DL (1998) Fundamentals of clinical trials, 3rd edn. Springer, New York

    Book  Google Scholar 

  6. Gunal AI, Ozalp G, Yoldas TK, Gunal SY, Kirciman E, Celiker H (2004) Gabapentin therapy for pruritus in haemodialysis patients: a randomized, placebo-controlled, double-blind trial. Nephrol Dial Transplant Off Publ Eur Dial Transpl Assoc Eur Renal Assoc 19(12):3137–3139

    CAS  Google Scholar 

  7. Manenti L, Vaglio A, Costantino E et al (2005) Gabapentin in the treatment of uremic itch: an index case and a pilot evaluation. J Nephrol 18(1):86–91

    CAS  PubMed  Google Scholar 

  8. Naini AE, Harandi AA, Khanbabapour S, Shahidi S, Seirafiyan S, Mohseni M (2007) Gabapentin: a promising drug for the treatment of uremic pruritus. Saudi J Kidney Dis Transpl 18(3):378–381

    PubMed  Google Scholar 

  9. Pongcharoen P, Fleischer AB Jr (2016) An evidence-based review of systemic treatments for itch. Eur J Pain 20(1):24–31

    Article  CAS  Google Scholar 

  10. Collins SL, Moore RA, McQuay HJ (1997) The visual analogue pain intensity scale: what is moderate pain in millimetres? Pain 72(1–2):95–97

    Article  CAS  Google Scholar 

  11. Pauli-Magnus C, Mikus G, Alscher DM et al (2000) Naltrexone does not relieve uremic pruritus: results of a randomized, double-blind, placebo-controlled crossover study. J Am Soc Nephrol 11(3):514–519

    CAS  PubMed  Google Scholar 

  12. (U.S.) NCI (2009) Common terminology criteria for adverse events (CTCAE). Rev. ed. U.S. Dept. of Health and Human Services, National Institutes of Health, National Cancer Institute, Bethesda

    Google Scholar 

  13. Nofal E, Farag F, Nofal A, Eldesouky F, Alkot R, Abdelkhalik Z (2016) Gabapentin: a promising therapy for uremic pruritus in hemodialysis patients: a randomized-controlled trial and review of literature. J Dermatol Treat 27(6):515–519

    Article  CAS  Google Scholar 

  14. Solak Y, Biyik Z, Atalay H et al (2012) Pregabalin versus gabapentin in the treatment of neuropathic pruritus in maintenance haemodialysis patients: a prospective, crossover study. Nephrology (Carlton) 17(8):710–717

    Article  CAS  Google Scholar 

  15. Manenti L, Tansinda P, Vaglio A (2009) Uraemic pruritus: clinical characteristics, pathophysiology and treatment. Drugs 69(3):251–263

    Article  CAS  Google Scholar 

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This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Correspondence to Lucio Manenti.

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All procedures were approved by the Azienda Ospedaliera S. Maria Nuova of Reggio Emilia Ethical Committee, and were compliant with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments.

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Rossi, G.M., Corradini, M., Blanco, V. et al. Randomized trial of two after-dialysis gabapentin regimens for severe uremic pruritus in hemodialysis patients. Intern Emerg Med 14, 1341–1346 (2019). https://doi.org/10.1007/s11739-019-02175-4

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  • DOI: https://doi.org/10.1007/s11739-019-02175-4

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