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Low-frequency fluctuation amplitude analysis of resting-state fMRI for functional brain response differences between acupuncture and moxibustion at Zusanli (ST 36) in patient with functional dyspepsia

静息态fMRI 低频振幅评价针刺与艾灸功能性消化不良患者足三里脑功能响应差异

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Abstract

Objective

To compare and analyze functional brain response characteristics by applying acupuncture or moxibustion to Zusanli (ST 36) in patients with functional dyspepsia (FD) and investigate the differences of central action mechanism resulting from acupuncture or moxibustion.

Methods

A total of eligible 24 FD cases were divided into two blood-oxygen-level dependent (BOLD) sequences for functional magnetic resonance imaging (fMRI) scan. The amplitude of low frequency fluctuation (ALFF) analyses were conducted on the data of location phase, structure phase, resting state before acupuncture/moxibustion, working state during acupuncture/moxibustion and resting state after acupuncture/moxibustion using Data Processing Assistant for Resting-State fMRI (DPARSF) software.

Results

Acupuncture and moxibustion produced significant differences in functional brain response. The working state during acupuncture/moxibustion mainly decreased ALFF values in the right supramarginal gyrus, right superior parietal lobule, right frontal gyrus, upper right occipital lobe, right precuneus and right cingulate gyrus. At the same time, it increased ALFF values in the left cerebellum, right caudate nucleus, right cerebellum and left inferior gyrus. The differences during the resting state after acupuncture/moxibustion were significantly smaller than the working state in intensity and size. It mainly resulted in decrease in ALFF values in the right postcentral gyrus and right supramarginal gyrus and increase in ALFF values in the left precuneus, orbital part of inferior frontal gyrus and right cerebellar peduncles.

Conclusion

Needling and moxibustion at Zusanli (ST 36) can produce significant differences in immediate functional brain response.

摘要

目的

比较分析针刺与艾灸足三里穴治疗功能性消化不良(FD)的脑功能响应特征, 探索针刺与艾灸中枢作 用机制的差异。

方法

选取符合条件的FD 患者24 例, 分针刺、艾灸两个BOLD 序列进行功能磁共振成像(fMRI) 扫描, 每个序列分为定位相、结构相、针刺/艾灸前静息态、针刺时/艾灸时任务态、针刺/艾灸后静息态, 采集数 据运用DPARSF 软件进行低频振幅(ALFF)分析。

结果

针刺与艾灸时的脑功能响应具有明显差异, 针刺时/艾灸时 任务态比较主要引起了右缘上回、右顶上小叶、右额中回、右枕叶上部、右楔前叶、右扣带回中部等脑区ALFF 值降低, 以及左小脑、右尾状回、右小脑、左小脑脚、左颞下回等脑区ALFF 值的升高; 针刺/艾灸后静息态的比 较差异在强度和区域大小上均明显小于任务态, 主要引起了右中央后回、右缘上回脑区ALFF 值的降低,以及左楔 前叶、左额下回眶部、右小脑脚脑区ALFF 值的升高。

结论

针刺与艾灸FD 患者足三穴的即时脑功能响应区域 有明显差异。

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Acknowledgments

This work was supported by National Basic Research Program of China (973 Program, 国家重点基础研究发展 计划, No. 2015CB554502); Project of China Postdoctoral Science Foundation ( 中国博士后面上基金课题, No. 2015M580689); Key Project of Hunan Province Administration of Traditional Chinese Medicine (湖南省中 医药管理局重点项目, No. 201409); Fund Project of Hunan Province Education Office (湖南省教育厅项目资助, No. 14C0856). Key Subject of Acupuncture Science of Hunan Province (湖南省针灸重点学科).

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Authors and Affiliations

  1. School of Acupuncture, Moxibustion & Tuina, Hunan University of Chinese Medicine, Changsha, 410208, China

    Mai-lan Liu  (刘迈兰), Can Liu  (刘灿), Zhi-gen Zhou  (周芝根), Jie Yu  (郁洁) & Xiao-rong Chang  (常小荣)

  2. School of Information Science and Engineering, Central South University, Changsha, 410002, China

    Jing Wu  (吴静) & Pei-shan Dai  (戴培山)

  3. Radiology Department, the First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, China

    Bo Li  (李波)

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  1. Mai-lan Liu  (刘迈兰)
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  2. Can Liu  (刘灿)
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  4. Bo Li  (李波)
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  5. Zhi-gen Zhou  (周芝根)
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  6. Pei-shan Dai  (戴培山)
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  7. Jie Yu  (郁洁)
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  8. Xiao-rong Chang  (常小荣)
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Correspondence to Jie Yu  (郁洁) or Xiao-rong Chang  (常小荣).

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Liu, Ml., Liu, C., Wu, J. et al. Low-frequency fluctuation amplitude analysis of resting-state fMRI for functional brain response differences between acupuncture and moxibustion at Zusanli (ST 36) in patient with functional dyspepsia. J. Acupunct. Tuina. Sci. 15, 230–236 (2017). https://doi.org/10.1007/s11726-017-1006-y

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  • DOI: https://doi.org/10.1007/s11726-017-1006-y

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