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Thermo-responsive self-folding feedstock with excellent shape memory programming

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Abstract

Shape memory polymers are smart materials that have the thermo-/chemo-responsive shape memory effect, can react to environmental stimuli, and exhibit excellent shape-fixity, shape-recovery and folding/unfolding effects. This type of shape memory polymer has shown great potential in the design and development of various drug delivery systems/devices. However, they have some intrinsic shortcomings, such as biodegradability, slow response rate, poor encapsulation ability of hydrophobic/hydrophilic drugs etc. These phenomenon sometimes limit their application in developing suitable drug delivery systems. In this study, we synthesized and characterized a poly(n-isopropyl acrylamide-4-acryloyloxy benzophenone) i.e., p(NIPAM-4ABP) based thermo-responsive self-folding shape-memory polymer with an excellent shape-memory behavior. The lower critical solution temperature of the synthesized p(NIPAM-4ABP) was determined using dynamic light scattering analysis to determine the effect of the addition of 4-ABP to the pNIPAM network. Fourier-transform infrared spectroscopy (FT-IR) was used to understand the reversibility of the shape-memory mechanism of the synthesized feedstock. A swelling study in different solvents was performed as a driving force to further encapsulate the drug molecules into p(NIPAM-4ABP) network. Finally, the shape memory behavior of this synthesized polymer was established via converted it into p(NIPAM-4ABP) feedstock to validate the excellent shape memory features.

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Acknowledgements

S.B. sincerely acknowledges the award support received from the SERB, Ministry of Science and Technology, Government of India, through SERB-SIRE fellowship vide Award No: SIR/2022/000111.

Funding

This study was funded through the Science and Engineering Research Board (SERB)-International Research Experience (SIRE) 2022–23 fellowship for the project titled “Responsive Self-folding Feedstock for Pharmaceutical 4D Printing Applications” vide Award No: SIR/2022/000111 supported by the SERB, Ministry of Science and Technology, Government of India, New Delhi.

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Authors and Affiliations

  1. Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, Changsari, Assam, 781101, India

    Purushottam Suryavanshi, Shubham Kawre & Subham Banerjee

  2. Pharmaceutical Engineering and 3D Printing Lab (PharmE3D), Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, The University of Texas at Austin, Austin, TX, 78712, USA

    Mohammed Maniruzzaman & Subham Banerjee

  3. Department of Medicinal Chemistry, NIPER-Guwahati, Changsari, Assam, 781101, India

    Kapileswar Seth

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  1. Purushottam Suryavanshi
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  2. Shubham Kawre
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  3. Mohammed Maniruzzaman
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  4. Kapileswar Seth
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  5. Subham Banerjee
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Correspondence to Kapileswar Seth or Subham Banerjee.

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Suryavanshi, P., Kawre, S., Maniruzzaman, M. et al. Thermo-responsive self-folding feedstock with excellent shape memory programming. Chem. Pap. 77, 3145–3154 (2023). https://doi.org/10.1007/s11696-023-02693-8

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  • DOI: https://doi.org/10.1007/s11696-023-02693-8

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