Abstract
Highly selective C3 position controllable mono-Michael additions or di-Michael additions of indolin-2-one to 2,4-dien-1-ones are described. The method was applied to a wide range of substrates and demonstrated excellent tolerance to a variety of substituents. This protocol has advantages of high selectivity, high atom economy, high yield, and mild conditions.
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Acknowledgements
The authors extremely grateful for the support of the National Natural Science Foundation of China (21462038) and Key Laboratory of Eco-environment Related Polymer Materials of Ministry of Education of China for the financial support of this work.
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Song, G., Li, Z. Highly selective controllable Michael additions of indolin-2-one with 2,4-dien-1-ones. Chem. Pap. 72, 1379–1388 (2018). https://doi.org/10.1007/s11696-018-0393-y
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DOI: https://doi.org/10.1007/s11696-018-0393-y