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Does One-Anastomosis Gastric Bypass Expose Patients to Gastroesophageal Reflux: a Systematic Review and Meta-analysis

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Abstract

This systematic review and meta-analysis aimed to investigate the incidence of new-onset gastroesophageal reflux, reflux change, esophagitis, Barrett’s esophagus, and revision due to reflux, gastritis, and marginal ulcer after one-anastomosis gastric bypass (OAGB). We performed subgroup analyses based on primary and revisional OAGB and time of follow-up. Meta-analysis of 87 studies with 27,775 patients showed a 6% rate of new-onset reflux after OAGB. Preoperative reflux status did not change significantly after OAGB. The rate of esophagitis and Barrett’s esophagus was 15% and 1%, respectively. The new-onset reflux rate after OAGB was significantly higher than gastric bypass but not different with sleeve gastrectomy. The current study showed a relatively low rate of reflux and its complications after OAGB, but it was significantly higher than Roux-en-Y gastric bypass.

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Authors and Affiliations

  1. Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Ali Esparham & Soheil Ahmadyar

  2. Department of General Surgery, Faculty of Medicine, Mashhad Medical Sciences, Islamic Azad University, Mashhad, Iran

    Tooraj Zandbaf

  3. Department of General Surgery, School of Medicine, Surgical Oncology Research Center, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran

    Amin Dalili & Alireza Rezapanah

  4. Center for Laparoscopic Obesity Surgery, 6240 N Durango Dr STE 120, Las Vegas, NV, 89149, USA

    Robert Rutledge

  5. Department of Surgery, University of Oklahoma School of Community Medicine, 1919 S. Wheeling Avenue, Suite 600, Tulsa, OK, 74104-5638, USA

    Zhamak Khorgami

  6. Harold Hamm Diabetes Center, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Zhamak Khorgami

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  1. Ali Esparham
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  2. Soheil Ahmadyar
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  4. Amin Dalili
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  7. Zhamak Khorgami
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Correspondence to Zhamak Khorgami.

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Key Points

• The current study showed a relatively low rate of gastroesophageal reflux and its complications after OAGB.

• OAGB had a significantly higher rate of new-onset reflux than Roux-en-Y gastric bypass.

• Studies with sample sizes > 500 had a 3% rate of new-onset reflux versus 7% for studies with lower sample sizes.

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Esparham, A., Ahmadyar, S., Zandbaf, T. et al. Does One-Anastomosis Gastric Bypass Expose Patients to Gastroesophageal Reflux: a Systematic Review and Meta-analysis. OBES SURG 33, 4080–4102 (2023). https://doi.org/10.1007/s11695-023-06866-y

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  • DOI: https://doi.org/10.1007/s11695-023-06866-y

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