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Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery

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Abstract

Introduction

Small intestinal bacterial overgrowth (SIBO) is a common complication of bariatric surgery. Digestive decontamination treatments with oral antibiotic therapy vary and are not codified. This retrospective study was conducted to analyse the characteristics of bariatric surgery patients who underwent a glucose breath test (GBT) and to analyse the effectiveness of the antibiotic decontamination therapy.

Materials and Methods

A total of 101 operated patients (Roux-en-Y bypass (RYB), omega bypass (ΩB) and sleeve gastrectomy (SG)) who underwent a GBT (75 g/250 mL) were included. Anthropometric data, symptoms of SIBO, type of surgery, use of proton pump inhibitors (PPIs) and antibiotic therapy were analysed. The effectiveness of the antibiotic treatment, defined by improvement of the symptoms, was evaluated during the follow-up.

Results

Of the 85 women and 16 men included (48.5 ± 3.6 years old), 63 underwent RYB, 31 underwent ΩB and 7 underwent SG. The GBT was positive in 83% of the patients. A positive test was associated with age (p < 0.001), female sex (p < 0.01) and PPI use (p < 0.01), but there was no significant difference according to the type of surgery. Sixty-one percent of patients treated with gentamicin/metronidazole sequential antibiotic therapy and 58% of patients treated with metronidazole alone achieved treatment efficacy (with no significant difference in efficacy between these treatments).

Conclusion

SIBO should be systematically considered in the context of abdominal symptoms in bariatric surgery patients, regardless the type of surgery, particularly in patients who are older or female and after PPI treatment. Digestive decontamination appears to be similar between gentamycin/metronidazole and metronidazole treatments.

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Authors and Affiliations

  1. Centre des Sciences du Goût et de l’Alimentation, AgroSup Dijon, CNRS, INRAE, Université Bourgogne Franche-Comté, F-21000, Dijon, France

    Thomas Mouillot, Sarah Lepers-Tassy, Corinne Leloup, Agnès Jacquin-Piques, Marie-Claude Brindisi & Laurent Brondel

  2. Service d’hépato-gastro-entérologie, CHU F. Mitterrand, F-21000, Dijon, France

    Thomas Mouillot, Nybel Rhyman, Sylvain Manfredi, Côme Lepage & Laurent Brondel

  3. Espace Médical Nutrition et Obésité, Ramsay Santé, 4 rue Lounes Matoub, F-21000, Dijon, France

    Cyril Gauthier

  4. Service de Pharmacie, CHU F. Mitterrand, F-21000, Dijon, France

    Justine Paris & Anne-Sophie Lang

  5. Service de neurophysiologie clinique, CHU F. Mitterrand, F-21000, Dijon, France

    Agnès Jacquin-Piques

  6. Service d’endocrinologie et diabétologie, CHU F. Mitterrand, F-21000, Dijon, France

    Marie-Claude Brindisi

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  1. Thomas Mouillot
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  2. Nybel Rhyman
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  3. Cyril Gauthier
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  4. Justine Paris
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  10. Agnès Jacquin-Piques
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  11. Marie-Claude Brindisi
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  12. Laurent Brondel
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Correspondence to Thomas Mouillot.

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Mouillot, T., Rhyman, N., Gauthier, C. et al. Study of Small Intestinal Bacterial Overgrowth in a Cohort of Patients with Abdominal Symptoms Who Underwent Bariatric Surgery. OBES SURG 30, 2331–2337 (2020). https://doi.org/10.1007/s11695-020-04477-5

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  • DOI: https://doi.org/10.1007/s11695-020-04477-5

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