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The Change in the Percent of Android and Gynoid Fat Mass Correlated with Increased Testosterone After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 6-Month Follow-Up

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Abstract

Objective

The study was designed to examine changes of body fat distribution after laparoscopic sleeve gastrectomy (LSG) in obese male patients and to confirm whether these changes are correlated with increased testosterone.

Methods

A total of 30 obese male patients with body mass index (BMI) 30–45 kg/m2 were enrolled in this study. Data on demographic characteristics, anthropometry, metabolic parameters, and body fat distribution were collected at baseline and 6 months after LSG. Body fat distribution was assessed by dual-energy X-ray absorptiometry (DXA).

Results

Six months after surgery, the BMI of participants (age 33.0 ± 9.5) decreased from 40.2 ± 5.2 to 30.8 ± 4.4 kg/m2, total testosterone increased from 2.4 ± 1.2 to 4.5 ± 1.8 ng/mL, and the percentage of testosterone deficiency in these patients decreased from 82.7 to 23.1%. Fat mass was significantly decreased in all regions, but the loss of fat mass in the android region was more than that in any other body region. After adjusting age and the BMI, the changes in android FM% and gynoid FM% were significantly correlated with an increase in total testosterone concentration (R2 = 0.187, R2 = 0.282, respectively).

Conclusion

In obese male patients with BMI 30–45 kg/m2, an increase of total testosterone correlated to the changes in android FM% and gynoid FM% at the sixth month after LSG surgery.

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Acknowledgments

The present study would not have been possible without the participation of these patients. This study is supported by grants from the Chinese National Natural Science Foundation (No. 81601269) and Shanghai Sailing Program (16YF1408900).

Author information

Author notes

  1. Jingyang Gao and Manna Zhang are equal contributors to this work.

Authors and Affiliations

  1. Department of Endocrinology & Metabolism, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, 301 Middle Yanchang Road, Shanghai, 200072, China

    Jingyang Gao, Manna Zhang, Cuiling Zhu, Yi Zhang, Xingchun Wang, Liang Li & Shen Qu

  2. Nanjing Medical University, 101 Longmian Avenue, Nanjing, Jiangsu Province, 211166, China

    Jingyang Gao & Shen Qu

  3. Department of Central Laboratory, Shanghai Tenth People’s Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200072, China

    Qi Liu

  4. National Metabolic Management Center, Shanghai Tenth People’s Hospital, 301 Middle Yanchang Road, Shanghai, 200072, China

    Donglei Zhou & Shen Qu

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  1. Jingyang Gao
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Contributions

JG and MZ analyzed the data and drafted the manuscript. JG, MZ, and SQ designed the study and directed implementation and data collection. JG, CZ, XW, and YZ collected the data. QL and LL provided necessary logistical support. DZ performed the surgery and participated in the discussion of this manuscript. MZ and SQ edited the manuscript for intellectual content and provided critical comments on the manuscript.

Corresponding author

Correspondence to Shen Qu.

Ethics declarations

Informed consent was obtained from all individual participants included in the study. The study was approved by the ethics committee of Shanghai Tenth People’s Hospital.

Conflict of Interest

The authors declare no competing interests.

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Gao, J., Zhang, M., Zhu, C. et al. The Change in the Percent of Android and Gynoid Fat Mass Correlated with Increased Testosterone After Laparoscopic Sleeve Gastrectomy in Chinese Obese Men: a 6-Month Follow-Up. OBES SURG 28, 1960–1965 (2018). https://doi.org/10.1007/s11695-018-3116-0

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