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The Association of SNP276G>T at Adiponectin Gene with Insulin Resistance and Circulating Adiponectin in Morbid Obese Patients After a Biliopancreatic Diversion Surgery

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Abstract

Background

The effects of rs1501299 variant of ADIPO gene on weight loss after bariatric surgery have not been evaluated. We decided to investigate the role of this genetic variant on anthropometric and biochemical outcomes such as serum adiponectin levels after biliopancreatic diversion (BPD) surgery in morbidly obese patients during 3 years.

Material and Methods

A sample of 64 patients with morbid obesity without diabetes mellitus was operated. Biochemical and anthropometric evaluation were realized at basal visit and at each visit during 3 years (1, 2, and 3 years).

Results

Percent excess weight loss, body mass index, weight, waist circumference, fat mass, blood pressure, fasting glucose, LDL cholesterol, total cholesterol, and triglycerides levels improved in both genotype groups. Fasting insulin levels and HOMA-IR decreased significantly only in non-T allele carriers. The decrease of fasting insulin levels at 3 years (delta −9.2 ± 3.4 vs −2.9 ± 2.2 mUI/L; p = 0.01) and HOMA-IR (delta −1.3 ± 0.3 vs −0.8 ± 0.4 units; p = 0.03) were higher in non-T allele carriers than T carriers. Adiponectin levels increased in all times after surgery in non-T allele carriers, too. The increase of adiponectin levels at 3 years (delta 12.2 ± 3.6 vs 1.8 ± 1.2 ng/mL; p = 0.01) was higher in non-T allele carriers than T carriers.

Conclusion

Non-T allele of ADIPOQ gene variant (rs1501299) is associated with increases in adiponectin levels and better improvements of insulin and HOMA-IR after BPD massive weight loss. These parameters remained unchanged in T allele carriers

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Authors and Affiliations

  1. Center of Investigation of Endocrinology and Nutrition, Medicine School, Department of Endocrinology and Nutrition, Hospital Clinico Universitario, Dept Surgery Hospital Universitario Rio Hortega, University of Valladolid, C/Los perales 16 Simancas, 47130, Valladolid, Spain

    Daniel Antonio de Luis, David Pacheco, D. Primo, Olatz Izaola & R. Aller

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  1. Daniel Antonio de Luis
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  2. David Pacheco
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  3. D. Primo
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  4. Olatz Izaola
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Correspondence to Daniel Antonio de Luis.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare that they have no conflict of interest.

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de Luis, D.A., Pacheco, D., Primo, D. et al. The Association of SNP276G>T at Adiponectin Gene with Insulin Resistance and Circulating Adiponectin in Morbid Obese Patients After a Biliopancreatic Diversion Surgery. OBES SURG 27, 3247–3252 (2017). https://doi.org/10.1007/s11695-017-2766-7

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  • DOI: https://doi.org/10.1007/s11695-017-2766-7

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