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The Longer-Term Effects of Roux-en-Y Gastric Bypass Surgery on Sodium Excretion

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Abstract

Background

Obesity is an independent risk factor for hypertension and chronic kidney disease. During the first months after bariatric surgery, an improvement of sodium excretion has been described. The aim of this work was to study the influence of bariatric surgery on sodium excretion at more than a year after the intervention.

Methods

Patients who have undergone Roux-en-Y gastric bypass (RYGB) and who had collected a 24-h urine sample before surgery more than 12 months ago were asked to participate. A second 24-h urine sample was collected. Blood pressure and weight were measured. The difference in sodium excretion before and after surgery was calculated, and the relationship with blood pressure and weight loss was investigated.

Results

We included 33 patients; the median follow-up time was 21 months (range 14–41). Sodium excretion was high before surgery (median 195 mmol/day, IQR range 167–247) and decreased by 18 % after surgery (median 160 mmol/day, IQR range 118–205, p = 0.015), while there were significant improvements in body weight (% EWL 80.9 ± 21.8), systolic blood pressure (126 to 120 mmHg, p = 0.02), and diastolic blood pressure (84 to 77 mmHg, p = 0.002), even with a reduced number of antihypertensive drugs.

Conclusions

After RYGB and considerable weight loss, sodium excretion remains high in the longer term. The profound improvement in blood pressure cannot be explained by reductions in sodium excretion after RYGB.

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Conflict of Interest

The authors certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

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Authors and Affiliations

  1. Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands

    Funda Celik, Mohamed Ahdi, Eelco W. Meesters, Dees P. M. Brandjes & Victor E. A. Gerdes

  2. Department of Surgery, Slotervaart Hospital, Amsterdam, The Netherlands

    Arnold van de Laar

  3. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

    Dees P. M. Brandjes & Victor E. A. Gerdes

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  1. Funda Celik
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  2. Mohamed Ahdi
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Correspondence to Funda Celik.

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Celik, F., Ahdi, M., Meesters, E.W. et al. The Longer-Term Effects of Roux-en-Y Gastric Bypass Surgery on Sodium Excretion. OBES SURG 23, 358–364 (2013). https://doi.org/10.1007/s11695-012-0764-3

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  • DOI: https://doi.org/10.1007/s11695-012-0764-3

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