Abstract
This study focuses on the development of a functional yoghurt oral film strip with antibacterial properties and probiotics [(Streptococcus thermophilus (S. thermophilus), Lactobacillus bulgaricus (L. bulgaricus), and Lactococcus cremoris (L. cremoris)] using a pectin/glycerol mixture. The tensile characters, colour, physiochemical characters, in vitro disintegration time, mouth dissolving time and in vitro dissolution test of the functional yoghurt oral strip was compared with commercial oral strips. The study examined the storage stability of functional yogurt oral strips over a period of 35 days at room temperature (25 °C) using blister packs made of polypropylene/aluminium and polypropylene/linear low-density polyethylene (LLDPE). Significant changes in mechanical properties, colour, surface pH, in vitro disintegration, and mouth dissolving time was observed with in vitro dissolution time of 6 min. Functional oral strip showed significant (p < 0.05) reduction in surface pH and probiotic viability, along with a significant increase in mouth dissolving time during storage in both packaging materials. Developed functional yoghurt oral strip also demonstrated better antibacterial quality on both storage materials with similar in vitro dissolution time periods. A satisfactory probiotic viability (> 6 log CFU/strip) was upheld for 28 days in a polypropylene/aluminium blister pack, resulting in an extended shelf life for the functional yogurt oral strip. Therefore, this functional yoghurt oral strip development can be considered as a promising production method to retain functional qualities with longer shelf life at room temperature.
Similar content being viewed by others
Data availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
References
M.E. Sanders, D. Merenstein, C.A. Merrifield, R. Hutkins, Probiotics for human use. Nutr. Bull. 43(3), 212–225 (2018). https://doi.org/10.1111/nbu.12334
T.K. Das, S. Pradhan, S. Chakrabarti, K.C. Mondal, K. Ghosh, Current status of probiotic and related health benefits. Appl. Food Res. 2(2), 100185 (2022). https://doi.org/10.1016/j.afres.2022.100185
P. Markowiak, K. Ślizewska, Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients (2017). https://doi.org/10.3390/nu9091021
M.A.R. Amalaradjou, A.K. Bhunia, Modern approaches in probiotics research to control foodborne pathogens (issue 67). Adv. Food Nutr. Res. (2012). https://doi.org/10.1016/B978-0-12-394598-3.00005-8
M.G. Mathipa-Mdakane, M.S. Thantsha, Lacticaseibacillus rhamnosus: a suitable candidate for the construction of novel bioengineered probiotic strains for targeted pathogen control. Foods (2022). https://doi.org/10.3390/foods11060785
M. Aspri, P. Papademas, D. Tsaltas, Review on non-dairy probiotics and their use in non-dairy based products. Fermentation 6(1), 1–20 (2020). https://doi.org/10.3390/fermentation6010030
R. Meghana, M. Velraj, An overview on mouth dissolving film. Asian J. Pharm. Clin. Res. 11(Special Issue 4), 44–47 (2018). https://doi.org/10.22159/ajpcr.2018.v11s4.31712
S. Misra, P. Pandey, C.G. Dalbhagat, H.N. Mishra, Emerging technologies and coating materials for improved probiotication in food products: a review. Food Bioprocess Technol. 15(5), 998–1039 (2022). https://doi.org/10.1007/s11947-021-02753-5
A. Terpou, A. Papadaki, I.K. Lappa, V. Kachrimanidou, L.A. Bosnea, N. Kopsahelis, Nutrients-11-01591 (1).Pdf. Nutrients 11(7), 32 (2019). https://www.mdpi.com/2072-6643/11/7/1591
A.A. Abdillah, A.L. Charles, Characterization of a natural biodegradable edible film obtained from arrowroot starch and iota-carrageenan and application in food packaging. Int. J. Biol. Macromol. 191, 618–626 (2021). https://doi.org/10.1016/j.ijbiomac.2021.09.141
I. Kumar, V. Pandit, A comprehensive review on oral strips. Int. J. Pharm. Sci. Rev. Res. 58(1), 17–26 (2019)
M.B.H. Mahboob, T. Riaz, M. Jamshaid, I. Bashir, S. Zulfiqar, Oral films: a comprehensive review. Int. Curr. Pharm. J. 5(12), 111–117 (2016). https://doi.org/10.3329/icpj.v5i12.30413
A.S. Kulkarni, H.A. Deokule, M.S. Mane, D.M. Ghadge, Exploration of different polymers for use in the formulation of oral fast dissolving strips. J. Curr. Pharm. Res. 2(1), 33–35 (2010)
B.P. Panda, N. Dey, M.E.B. Rao, Development of innovative orally fast disintegrating film dosage forms: a review. Int. J. Pharm. Sci. Nanotechnol. 5(2), 1666–1674 (2012). https://doi.org/10.37285/ijpsn.2012.5.2.2
A. Kistaubayeva, M. Abdulzhanova, S. Zhantlessova, I. Savitskaya, T. Karpenyuk, A. Goncharova, Y. Sinyavskiy, The effect of encapsulating a prebiotic-based biopolymer delivery system for enhanced probiotic survival. Polymers 15(7), 1–15 (2023). https://doi.org/10.3390/polym15071752
R. Sevinç Özakar, E. Özakar, Current overview of oral thin films. Turk. J. Pharm. Sci. 18(1), 111–121 (2021). https://doi.org/10.4274/tjps.galenos.2020.76390
P. Jantrawut, T. Chaiwarit, K. Jantanasakulwong, C.H. Brachais, O. Chambin, Effect of plasticizer type on tensile property and in vitro indomethacin release of thin films based on low-methoxyl pectin. Polymers (2017). https://doi.org/10.3390/polym9070289
L.A.K. Saleena, A.A.L. Song, Y.A. Yusof et al., Development of optimized functional clove fortified probiotic yoghurt. J. Food Sci. Technol. (2023). https://doi.org/10.1007/s13197-023-05904-y
A. Ket-on, N. Pongmongkol, A. Somwangthanaroj, T. Janjarasskul, K. Tananuwong, Properties and storage stability of whey protein edible film with spice powders. J. Food Sci. Technol. 53(7), 2933–2942 (2016). https://doi.org/10.1007/s13197-016-2259-z
R. Bala, S. Khanna, P. Pawar, Design optimization and in vitro–in vivo evaluation of orally dissolving strips of clobazam. J. Drug Deliv. 2014, 1–15 (2014). https://doi.org/10.1155/2014/392783
V.K. Chandur, Formulation evaluation and optimization of fast dissolving oral strips of isosorbide mononitrate. Am. J. Pharmtech Res. 4(3), 1–20 (2014)
H. Singh, M. Kaur, H. Verma, Optimization and evaluation of desloratadine oral strip: an innovation in paediatric medication. Sci. World J. (2013). https://doi.org/10.1155/2013/395681
R. Kumar Gunda, J. Suresh Kumar, C. Priyanaka, L. Sravani, B. Naveena, B. Yamini, S. Mansur Ali, Formulation development and evaluation of oral dissolving films—a review. J. Anal. Pharm. Res. 11(3), 131–134 (2022). https://doi.org/10.15406/japlr.2022.11.00414
N.B.K. Zaman, N.K. Lin, P.L. Phing, Chitosan film incorporated with Garcinia atroviridis for the packaging of Indian mackerel (Rastrelliger kanagurta). Cienc. Agrotecnol. 42(6), 666–675 (2018). https://doi.org/10.1590/1413-70542018426019918
A. Deepthi, B. Venkateswara Reddy, K. Navaneetha, Formulation and evaluation of fast dissolving oral films of zolmitriptan. Am. J. Adv. Drug Deliv. 2(2), 153–163 (2014)
A. Linku, J. Sijimol, Formulation and evaluation of fast dissolving oral film of anti-allergic drug. Asian J. Pharm. Res. Dev. 6(3), 5–16 (2018). https://doi.org/10.22270/ajprd.v6i3.374
K. Pramod, U.K. Ilyas, Y.T. Kamal, S. Ahmad, S.H. Ansari, J. Ali, Development and validation of RP-HPLC-PDA method for the quantification of eugenol in developed nanoemulsion gel and nanoparticles. J. Anal. Sci. Technol. 4(1), 1 (2013). https://doi.org/10.1186/2093-3371-4-16
S.N. Wai, Y.H. How, L.A.K. Saleena, P. Degraeve, N. Oulahal, L.P. Pui, Chitosan–sodium caseinate composite edible film incorporated with probiotic Limosilactobacillus fermentum. Foods 11(22), 3583 (2022)
E. Abdollahzadeh, S.M. Ojagh, A.A.I. Fooladi, B. Shabanpour, M. Gharahei, Effects of probiotic cells on the mechanical and antibacterial properties of sodium-caseinate films. Appl. Food Biotechnol. 5(3), 155–162 (2018). https://doi.org/10.22037/afb.v%vi%i.20360
A.M. López De Lacey, M.E. López-Caballero, J. Gómez-Estaca, M.C. Gómez-Guillén, P. Montero, Functionality of Lactobacillus acidophilus and Bifidobacterium bifidum incorporated to edible coatings and films. Innov. Food Sci. Emerg. Technol. 16, 277–282 (2012). https://doi.org/10.1016/j.ifset.2012.07.001
F.P. Downes, K. Ito, Culture methods for enumeration of microorganisms, in Compendium of Methods for the Microbiological Examination of Foods, 4th edn. (APHA, Washington, D.C., 2001)
N.O. Nwamaioha, S.A. Ibrahim, A selective medium for the enumeration and differentiation of Lactobacillus delbrueckii ssp. bulgaricus. J. Dairy Sci. 101(6), 4953–4961 (2018). https://doi.org/10.3168/jds.2017-14155
Y. Liu, N. Charamis, S. Boeren, J. Blok, A.G. Lewis, E.J. Smid, T. Abee, Physiological roles of short-chain and long-chain menaquinones (vitamin K2) in Lactococcus cremoris. Front. Microbiol. 13(March), 1–18 (2022). https://doi.org/10.3389/fmicb.2022.823623
R.J.B. Heinemann, R.A. Carvalho, C.S. Favaro-Trindade, Orally disintegrating film (ODF) for delivery of probiotics in the oral cavity—development of a novel product for oral health. Innov. Food Sci. Emerg. Technol. 19, 227–232 (2013). https://doi.org/10.1016/j.ifset.2013.04.009
B. Yang, C. Wei, Y. Yang, Q. Wang, S. Li, Evaluation about wettability, water absorption or swelling of excipients through various methods and the correlation between these parameters and tablet disintegration. Drug Dev. Ind. Pharm. 44(9), 1417–1425 (2018). https://doi.org/10.1080/03639045.2018.1453519
H.M. Muzawar, K. Viresk, A.R.S. Chandur, Formulation evaluation and optimization of fast dissolving oral strips of isosorbide mononitrate. Am. J. Pharmtech Res. 4(3), 453–472 (2019)
J. Castro-Rosas, A.M. Cruz-Galvez, C.A. Gomez-Aldapa, R.N. Falfan-Cortes, F.A. Guzman-Ortiz, M.L. Rodríguez-Marín, Biopolymer films and the effects of added lipids, nanoparticles and antimicrobials on their mechanical and barrier properties: a review. Int. J. Food Sci. Technol. 51(9), 1967–1978 (2016). https://doi.org/10.1111/ijfs.13183
S.K. Patel, D.R. Shah, S. Tiwari, Bioadhesive films containing fluconazole for mucocutaneous candidiasis. Indian J. Pharm. Sci. 77(1), 55–61 (2015). https://doi.org/10.4103/0250-474X.151601
R. Bala, S. Khanna, P. Pawar, S. Arora, Orally dissolving strips: a new approach to oral drug delivery system. Int. J. Pharm. Investig. 3(2), 67 (2013). https://doi.org/10.4103/2230-973x.114897
K. Sajayan, S. KK, S.C. C, J. MC, R.S. Nair, S. K, S. Kappally, S. KR, J. Joseph, Development and evaluation of fast dissolving oral films of mefenamic acid for the management of fever. Indian J. Pharm. Educ. Res. 57(1s), s41–s51 (2023). https://doi.org/10.5530/ijper.57.1s.6
M.G.A. Mohammed, S.A. Adinarayana, Formulation design of hydrocortisone films for the treatment of aphthous ulcers. Turk. J. Pharm. Sci. 16(3), 348–355 (2019). https://doi.org/10.4274/tjps.galenos.2018.75046
W.H. Sperber, M.P. Doyle, Compendium of the Microbiological Spoilage of Foods and Beverages. Food Microbiology and Food Safety (Springer, New York, NY, 2009). https://doi.org/10.1007/978-1-4419-0826-1
H.A. Deokule, S.S. Pimple, P.D. Chaudhari, A.S. Kulkarni, Fabrication and evaluation of mouth dissolving strips of metoclopramide hydrochloride by using novel film former. Res. J. Pharm. Technol. 14(10), 5515–5520 (2021)
M.L. Sanyang, S.M. Sapuan, M. Jawaid, M.R. Ishak, J. Sahari, Effect of plasticizer type and concentration on physical properties of biodegradable films based on sugar palm (Arenga pinnata) starch for food packaging. J. Food Sci. Technol. 53(1), 326–336 (2016). https://doi.org/10.1007/s13197-015-2009-7
M.G.A. Vieira, M.A. Da Silva, L.O. Dos Santos, M.M. Beppu, Natural-based plasticizers and biopolymer films: a review. Eur. Polym. J. 47(3), 254–263 (2011). https://doi.org/10.1016/j.eurpolymj.2010.12.011
N.S. Kadbhane, D.M. Shinkar, R.B. Saudagar, An overview on: orally fast dissolving film. Int. J. ChemTech Res. 10(7), 815–821 (2017)
L. Nurdianti, T. Rusdiana, I. Sopyan, N.A. Putriana, H.R. Aiman, T.R. Fajria, Characteristic comparison of an intraoral thin film containing astaxanthin nanoemulsion using sodium alginate and gelatin polymers. Turk. J. Pharm. Sci. 18(3), 289–295 (2021). https://doi.org/10.4274/tjps.galenos.2020.25483
Y. Swetha, S. Naga Jyothi, Md. Gulshan, N. RamaRao, An overview on oroflash release films. Int. J. Pharm. Pharm. Res. 8(4), 66–84 (2017)
N.H. Che Hamzah, N. Khairuddin, I.I. Muhamad, M.A. Hassan, Z. Ngaini, S.R. Sarbini, Characterisation and colour response of smart sago starch-based packaging films incorporated with Brassica oleracea anthocyanin. Membranes (2022). https://doi.org/10.3390/membranes12100913
N. Choobkar, A. Daraei Garmakhany, A.R. Aghajani, M. Ataee, Response surface optimization of pudding formulation containing fish gelatin and clove (Syzygium aromaticum) and cinnamon (Cinnamomum verum) powder: effect on color, physicochemical, and sensory attributes of the final pudding product. Food Sci. Nutr. 10(4), 1257–1274 (2022). https://doi.org/10.1002/fsn3.2761
S. Hemavathy, P. Sinha, U. Ubaidulla, G. Rathnam, A detailed account on novel oral fast dissolving strips: application and future prospects. Dep. Pharm. 10(4), 773–787 (2022)
A. Khristi, T. Soni, B. Suhagia, Design development & in-vitro evaluation of oral rapid mouth dissolving tablet containing sildenafil aspirin co-crystals using QbD approach. J. Chem. Pharm. Res. 8(10), 259–274 (2016)
M. Saab, M.M. Mehanna, Disintegration time of orally dissolving films: various methodologies and in-vitro/in-vivo correlation. Pharmazie 74(4), 227–230 (2019). https://doi.org/10.1691/ph.2019.8231
N. Janigová, J. Elbl, S. Pavloková, J. Gajdziok, Effects of various drying times on the properties of 3D printed orodispersible films. Pharmaceutics (2022). https://doi.org/10.3390/pharmaceutics14020250
J. Carolina Visser, O.A.F. Weggemans, R.J. Boosman, K.U. Loos, H.W. Frijlink, H.J. Woerdenbag, Increased drug load and polymer compatibility of bilayered orodispersible films. Eur. J. Pharm. Sci. 107(May), 183–190 (2017). https://doi.org/10.1016/j.ejps.2017.07.010
Astrazeneca, F. Al Husban, glad L. H. C. WO2017182589A1.pdf. (2017), p. 7
N. Desai, M. Masen, P. Cann, B. Hanson, C. Tuleu, M. Orlu, Modernising orodispersible film characterisation to improve palatability and acceptability using a toolbox of techniques. Pharmaceutics 14(4), 1–15 (2022). https://doi.org/10.3390/pharmaceutics14040732
K. Anjireddy, S. Karpagam, Micro and nanocrystalline cellulose based oral dispersible film; preparation and evaluation of in vitro/in vivo rapid release studies for donepezil. Braz. J. Pharm. Sci. 56, 1–17 (2020). https://doi.org/10.1590/s2175-97902020000117797
J.N. Sowjanya, P.R. Rao, Development, optimization, and invitro evaluation of novel fast dissolving oral films (FDOF’s) of Uncaria tomentosa extract to treat osteoarthritis. Heliyon 9(3), e14292 (2023). https://doi.org/10.1016/j.heliyon.2023.e14292
S. Kunte, P. Tandale, Fast dissolving strips: a novel approach for the delivery of verapamil. J. Pharm. Bioallied Sci. 2(4), 325 (2010). https://doi.org/10.4103/0975-7406.72133
G.E. Yassin, H.A. Abass, Design and evaluation of fast dissolving oro-dispersible films of metoclopramide hydrochloride using 32 multifactorial designs. Int. J. Pharm. Pharm. Sci. 8(7), 218–222 (2016)
Y. Takeuchi, N. Ikeda, K. Tahara, H. Takeuchi, Mechanical characteristics of orally disintegrating films: comparison of folding endurance and tensile properties. Int. J. Pharm. 589(September), 119876 (2020). https://doi.org/10.1016/j.ijpharm.2020.119876
M. Zaman, R. Hassan, S. Razzaq, A. Mahmood, M.W. Amjad, M.A.G. Raja, A.A. Qaisar, A. Majeed, M. Hanif, R.A. Tahir, Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL. Sci. Prog. 103(4), 1–21 (2020). https://doi.org/10.1177/0036850420964302
F. Cilurzo, I.E. Cupone, P. Minghetti, F. Selmin, L. Montanari, Fast dissolving films made of maltodextrins. Eur. J. Pharm. Biopharm. 70(3), 895–900 (2008). https://doi.org/10.1016/j.ejpb.2008.06.032
M.P. Tedesco, C.A. Monaco-Lourenço, R.A. Carvalho, Gelatin/hydroxypropyl methylcellulose matrices—polymer interactions approach for oral disintegrating films. Mater. Sci. Eng. C 69, 668–674 (2016). https://doi.org/10.1016/j.msec.2016.07.023
M. Preis, K. Knop, J. Breitkreutz, Mechanical strength test for orodispersible and buccal films. Int. J. Pharm. 461(1–2), 22–29 (2014). https://doi.org/10.1016/j.ijpharm.2013.11.033
M. Rashighi, J.E. Harris, Impact of super-disintegrants and film thickness on disintegration time of strip films loaded with poorly water-soluble drug microparticles. Physiol. Behav. (2017). https://doi.org/10.1053/j.gastro.2016.08.014.CagY
B.N. Nalluri, B. Sravani, V.S. Anusha, R. Sribramhini, K.M. Maheswari, Development and evaluation of mouth dissolving films of sumatriptan succinate for better therapeutic efficacy. J. Appl. Pharm. Sci. 3(8), 161–166 (2013). https://doi.org/10.7324/JAPS.2013.3828
P.J.P. Espitia, W.X. Du, R. de Jesús Avena-Bustillos, N. de Fátima Ferreira Soares, T.H. McHugh, Edible films from pectin: physical-mechanical and antimicrobial properties—a review. Food Hydrocoll. 35, 287–296 (2014). https://doi.org/10.1016/j.foodhyd.2013.06.005
T. Nisar, Z.C. Wang, X. Yang, Y. Tian, M. Iqbal, Y. Guo, Characterization of citrus pectin films integrated with clove bud essential oil: physical, thermal, barrier, antioxidant and antibacterial properties. Int. J. Biol. Macromol. 106, 670–680 (2018). https://doi.org/10.1016/j.ijbiomac.2017.08.068
E. Bragason, T. Berhe, D. Dashe, K.I. Sørensen, M.E. Guya, E.B. Hansen, Antimicrobial activity of novel Lactococcus lactis strains against Salmonella Typhimurium DT12, Escherichia coli O157:H7 VT− and Klebsiella pneumoniae in raw and pasteurised camel milk. Int. Dairy J. 111, 104832 (2020). https://doi.org/10.1016/j.idairyj.2020.104832
L. Ravindran, N. Manjunath, R.P. Darshan, S.G.A. Manuel, In vitro study analysis of antimicrobial properties of lactic acid bacteria against pathogens. J. Bio Innov. 5(2), 262–269 (2016)
P. Sagar, P. Sharma, R. Singh, Antibacterial efficacy of different combinations of clove, eucalyptus, ginger, and selected antibiotics against clinical isolates of Pseudomonas aeruginosa. AYU (An International Quarterly Journal of Research in Ayurveda) 41(2), 123 (2020). https://doi.org/10.4103/ayu.ayu_101_19
A. Güneş Bayir, M.G. Bilgin, S.S. Kutlu, D. Demirci, F.N. Gölgeci, Microbiological, chemical and sensory analyzes of produced probiotic yoghurts added clove and propolis. Icontech Int. J. 4(2), 1–14 (2020). https://doi.org/10.46291/icontechvol4iss2pp1-14
G.E. Gardiner, E. O’Sullivan, J. Kelly, M.A.E. Auty, G.F. Fitzgerald, J.K. Collins, R.P. Ross, C. Stanton, Comparative survival rates of human-derived probiotic Lactobacillus paracasei and L. salivarius strains during heat treatment and spray drying. Appl. Environ. Microbiol. 66(6), 2605–2612 (2000). https://doi.org/10.1128/AEM.66.6.2605-2612.2000
S. Santacruz, M. Castro, Viability of free and encapsulated Lactobacillus acidophilus incorporated to cassava starch edible films and its application to Manaba fresh white cheese. LWT 93(April), 570–572 (2018). https://doi.org/10.1016/j.lwt.2018.04.016
T. Mehdizadeh, H. Tajik, A.M. Langroodi, R. Molaei, A. Mahmoudian, Chitosan-starch film containing pomegranate peel extract and Thymus kotschyanus essential oil can prolong the shelf life of beef. Meat Sci. 163(May 2019), 108073 (2020). https://doi.org/10.1016/j.meatsci.2020.108073
C. Soukoulis, S. Behboudi-Jobbehdar, L. Yonekura, C. Parmenter, I. Fisk, Impact of milk protein type on the viability and storage stability of microencapsulated Lactobacillus acidophilus NCIMB 701748 using spray drying. Food Bioprocess Technol. 7(5), 1255–1268 (2014). https://doi.org/10.1007/s11947-013-1120-x
P.K. Akman, F. Bozkurt, K. Dogan, F. Tornuk, F. Tamturk, Fabrication and characterization of probiotic Lactobacillus plantarum loaded sodium alginate edible films. J. Food Meas. Charact. 15(1), 84–92 (2021). https://doi.org/10.1007/s11694-020-00619-6
S. Sathyabama, M. Ranjith kumar, P. Bruntha devi, R. Vijayabharathi, V. Brindha priyadharisini, Co-encapsulation of probiotics with prebiotics on alginate matrix and its effect on viability in simulated gastric environment. LWT 57(1), 419–425 (2014). https://doi.org/10.1016/j.lwt.2013.12.024
T. Nisar, A. Alim, T. Iqbal, M. Iqbal, S. Tehseen, W. Zi-Chao, Y. Guo, Functionality of different probiotic strains embedded in citrus pectin based edible films. Int. J. Food Sci. Technol. 57(2), 1005–1015 (2022). https://doi.org/10.1111/ijfs.15460
S. Namratha, V. Sreejit, R. Preetha, Fabrication and evaluation of physicochemical properties of probiotic edible film based on pectin–alginate–casein composite. Int. J. Food Sci. Technol. 55(4), 1497–1505 (2020). https://doi.org/10.1111/ijfs.14550
R. Altamirano-Fortoul, R. Moreno-Terrazas, A. Quezada-Gallo, C.M. Rosell, Viability of some probiotic coatings in bread and its effect on the crust mechanical properties. Food Hydrocoll. 29(1), 166–174 (2012). https://doi.org/10.1016/j.foodhyd.2012.02.015
A.S. Bauer, K. Leppik, K. Galić, I. Anestopoulos, M.I. Panayiotidis, S. Agriopoulou, M. Milousi, I. Uysal-Unalan, T. Varzakas, V. Krauter, Cereal and confectionary packaging: background, application and shelf-life extension. Foods (2022). https://doi.org/10.3390/foods11050697
Funding
This work was supported by the Research Excellence & Innovative Grant (REIG) scheme, UCSI University, Malaysia (REIG – FAS- 2021/003).
Author information
Authors and Affiliations
Contributions
Study design: Lejaniya Abdul Kalam Saleena and Liew Phing Pui; Experiments: Lejaniya Abdul Kalam Saleena; Data analysis: Lejaniya Abdul Kalam Saleena, Liew Phing Pui, Kar Lin Nyam; Writing—original draft preparation: Lejaniya Abdul Kalam Saleena; Writing—review & editing: Lejaniya Abdul Kalam Saleenaa, Kar Lin Nyam, Yus Aniza Yusof, Adelene Ai-Lian Song, Lionel Lian Aun In, and Liew Phing Pui; All authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors declare no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Saleena, L.A.K., Nyam, K.L., Yusof, Y.A. et al. Characterization and shelf-life study of functional yoghurt based oral strip in polypropylene–aluminium/LLDPE blister pack. Food Measure 18, 3771–3782 (2024). https://doi.org/10.1007/s11694-024-02448-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11694-024-02448-3