Résumé
Le tissu adipeux est reconnu en tant « qu’organe » capable de synthétiser et de sécréter plusieurs centaines de molécules qui exercent des actions pléiotropes, en particulier sur la régulation du métabolisme glucidolipidique, l’inflammation, l’angiogenèse ou la reproduction, molécules rassemblées sous le terme d’adipokines. De nombreux travaux ont été réalisés sur les adipokines « phares » que sont la leptine et l’adiponectine, notamment en raison de leur implication dans le métabolisme énergétique. Cependant, de nombreuses adipokines ont émergé depuis et représentent des cibles prometteuses, en particulier dans le contexte des désordres métaboliques associés à l’obésité. Dans cet article, nous ferons un point non exhaustif des adipokines « classiques » ou plus récemment découvertes dans le domaine de l’obésité et des maladies métaboliques.
Abstract
Adipose tissue is now recognized as an endocrine organ able to synthesize and secrete several hundred molecules molecules, which exert pleiotropic actions in particular on the regulation of carbohydrate and lipid metabolism, inflammation, angiogenesis, or reproduction. These molecules are gathered under the term adipokines. Many studies have been done on “leading” adipokines, leptin, and adiponectin, particularly because of their involvement in energy metabolism. However, many other adipokines have been more recently identified and represent promising targets in the context of metabolic disorders associated with obesity. In this review, we present a non-exhaustive point of “classic” and more recently discovered adipokines in the field of obesity and metabolic diseases.
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Bastard, JP., Bastard, C., Fellahi, S. et al. Les adipokines : état des lieux et nouveautés. Obes 11, 181–193 (2016). https://doi.org/10.1007/s11690-016-0537-6
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DOI: https://doi.org/10.1007/s11690-016-0537-6