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Microorganism-derived biological macromolecules for tissue engineering

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Abstract

According to literature, certain microorganism productions mediate biological effects. However, their beneficial characteristics remain unclear. Nowadays, scientists concentrate on obtaining natural materials from live creatures as new sources to produce innovative smart biomaterials for increasing tissue reconstruction in tissue engineering and regenerative medicine. The present review aims to introduce microorganism-derived biological macromolecules, such as pullulan, alginate, dextran, curdlan, and hyaluronic acid, and their available sources for tissue engineering. Growing evidence indicates that these materials can be used as biological material in scaffolds to enhance regeneration in damaged tissues and contribute to cosmetic and dermatological applications. These natural-based materials are attractive in pharmaceutical, regenerative medicine, and biomedical applications. This study provides a detailed overview of natural-based biomaterials, their chemical and physical properties, and new directions for future research and therapeutic applications.

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Authors and Affiliations

  1. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran, 1591639675, Iran

    Naser Amini, Peiman Brouki Milan, Vahid Hosseinpour Sarmadi & Ahmad Hivechi

  2. Institutes of Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran

    Naser Amini, Peiman Brouki Milan, Vahid Hosseinpour Sarmadi & Bahareh Derakhshanmehr

  3. Department of Tissue Engineering and Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, 1449614535, Iran

    Peiman Brouki Milan

  4. Department of Pharmaceutics, University of Minnesota, Minneapolis, MN, 55455, USA

    Ahmad Hivechi

  5. Burn Research Center, Department of Plastic and Reconstructive Surgery, Iran University of Medical Sciences, Tehran, 1591639675, Iran

    Fateme Khodaei

  6. Department of Medical Biotechnology, Faculty of Paramedicine, Guilan University of Medical Sciences, Rasht, 4477166595, Iran

    Masoud Hamidi

  7. Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, 1477893855, Iran

    Sara Ashraf & Ghazaleh Larijani

  8. Cellular and Molecular Research Centre, Qom University of Medical Sciences, Qom, 3715835155, Iran

    Alireza Rezapour

  9. Department of Tissue Engineering and Regenerative Medicine, School of Medicine, Qom University of Medical Sciences, Qom, 3715835155, Iran

    Alireza Rezapour

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  1. Naser Amini
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  2. Peiman Brouki Milan
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  4. Bahareh Derakhshanmehr
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  5. Ahmad Hivechi
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  8. Sara Ashraf
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  9. Ghazaleh Larijani
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Correspondence to Peiman Brouki Milan or Alireza Rezapour.

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Naser Amini, Peiman Brouki Milan, Vahid Hosseinpour Sarmadi, Bahareh Derakhshanmehr, Ahmad Hivechi, Fateme Khodaei, Masoud Hamidi, Sara Ashraf, Ghazaleh Larijani, and Alireza Rezapour declare that they have no conflict of interests. This manuscript is a review article and does not involve a research protocol requiring approval by the relevant institutional review board or ethics committee.

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Amini, N., Milan, P.B., Sarmadi, V.H. et al. Microorganism-derived biological macromolecules for tissue engineering. Front. Med. 16, 358–377 (2022). https://doi.org/10.1007/s11684-021-0903-0

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  • DOI: https://doi.org/10.1007/s11684-021-0903-0

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