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Altered connectivity in the cognitive control-related prefrontal cortex in Parkinson’s disease with rapid eye movement sleep behavior disorder

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Abstract

Rapid eye movement sleep behavior disorder (RBD) frequently occurs in Parkinson’s disease (PD), however, the exact pathophysiological mechanism is not clear. The prefrontal cortex (PFC), especially ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), and inferior frontal gyrus (IFG) which may play roles by regulating cognitive control processes. The purpose of this study was to investigate whether there is abnormal functional connectivity (FC) maps and volume changes in PD with RBD(PD-RBD). We recruited 20 PD-RBD, 20 PD without RBD (PD-nRBD), and 20 normal controls (NC). We utilized resting-state functional Magnetic Resonance Imaging (rs-MRI) to explore FC changes based on regions of interest (VLPFC, DLPFC, and IFG), and used voxel-based morphology technology to analyze whole-brain volumes by 3D-T1 structural MRI. Except the REM sleep behavioral disorders questionnaire (RBDSQ), the PD-RBD showed lower visuospatial/executive and attention scores than the NC group. The RBDSQ scores were significantly positively correlated with zFC of right DLPFC to bilateral posterior cingulate cortex (PCC) (P = 0.0362, R = 0.4708, AlphaSim corrected) and also significantly positively correlated with zFC of left VLPFC to right inferior temporal (P = 0.0157, R = 0.5323, AlphaSim corrected) in PD-RBD group. Furthermore, abnormal correlations with zFC values were also found in some cognitive subdomains in PD-RBD group. The study may suggest that in PD-RBD patients, the presence of RBD may be related to the abnormal FC of VLPFC and DLPFC, meanwhile, the abnormal FC of DLPFC and IFG may be related to the mechanisms of cognitive impairment.

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Data availability

The data that support the findings of this study are available from the corresponding author upon request.

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This research was supported by the National Natural Science Foundation of China (No.81871002, 81471334, 81100981) and the National Key Clinical Specialties Construction Program of China.

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  1. Department of Neurology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China

    Jinjing Liu, Xiaoya Zou, Qian Yu, Zhaoying Dong, Hongzhou Zuo, Xiaocui Chen, Xinyi Du, Dezhi Zou, Yu Han & Oumei Cheng

  2. Department of Rehabilitation Medicine, Daping Hospital, Army Medical University, Chongqing, 400042, China

    Jinjing Liu

  3. Department of Radiology, the First Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China

    Jinming Gu & Juan Peng

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Conception and study design (Oumei Cheng, Juan Peng and Jinjing Liu), data collection or acquisition (Jinjing Liu, Xiaoya Zou, Jinming Gu, Qian Yu, Zhaoying Dong, Hongzhou Zuo, Xiaocui Chen, Xinyi Du, Dezhi Zou and Yu Han), statistical analysis (Jinjing Liu and Jinming Gu), interpretation of results (Jinjing Liu and Xiaoya Zou), drafting the manuscript work or revising it critically for important intellectual content (Oumei Cheng, Juan Peng and Jinjing Liu) and approval of final version to be published and agreement to be accountable for the integrity and accuracy of all aspects of the work (All authors).

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Liu, J., Zou, X., Gu, J. et al. Altered connectivity in the cognitive control-related prefrontal cortex in Parkinson’s disease with rapid eye movement sleep behavior disorder. Brain Imaging and Behavior 17, 702–714 (2023). https://doi.org/10.1007/s11682-023-00796-0

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