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Effect of SeO2 on telomerase activity in human lung carcinoma cell line GLC-82

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Chinese Journal of Cancer Research

Abstract

Objective: To observe the effect of inhibition of telomerase activity by selenium dioxide (SeO2) on lung carcinoma cell line GLC-82. Methods: TRAP-PCR-ELISA was used to study the changes of telomerase activity in human pulmonary adenocarcinoma cell line GLC-82 treated by SeO2 at the different concentrations (3, 10, 30 µmol/L) and for different times (24, 48, and 72 h). Results: SeO2 inhibited the telomerase activity of GLC-82 at the different concentrations after treatment of 24, 48 and 72 h. Conclusion: SeO2 inhibits from telomerase activity of human lung carcinoma line GLC-82. The effect of inhibition is dose-dependant and time-dependant.

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Authors and Affiliations

  1. Department of Pathology, Lanzhou General Hospital of PLA, 730050, Lanzhou

    Chen Wei-xiang, Cao Xiao-zhe & Zhu Ren-zhi

Authors
  1. Chen Wei-xiang
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  2. Cao Xiao-zhe
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  3. Zhu Ren-zhi
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Corresponding author

Correspondence to Cao Xiao-zhe.

Additional information

Foundation item: This work was supported by a grant from 9th five-year plan youth project of PLA (No.98Q010).

Biography: CHEN Wei-xiang (1975-), candidate for medical master, Lanzhou Medical College, majors in molecular pathology of lung carcinoma.

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Chen, Wx., Cao, Xz. & Zhu, Rz. Effect of SeO2 on telomerase activity in human lung carcinoma cell line GLC-82. Chin J Cancer Res 15, 202–204 (2003). https://doi.org/10.1007/s11670-003-0026-y

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  • DOI: https://doi.org/10.1007/s11670-003-0026-y

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