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Dysmobility syndrome: a case-series study describing a musculoskeletal syndrome in postmenopausal Mexican women

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Abstract

Summary

“Dysmobility Syndrome” (DS) is a term that correlates sarcopenia and osteoporosis together with mobility disturbances, obesity, fractures, and falls. The prevalence of DS is of 74% in this study. Further research with bigger sample sizes is needed to describe if prevalence and DS characteristics are similar in other studies.

Purpose

“Dysmobility Syndrome” (DS) correlates sarcopenia and osteoporosis together with mobility disturbances, obesity, fractures, and falls, all of which are related to adverse outcomes in the health of the elderly; however, there are no studies of DS in Mexican patients. In this study, we aimed to describe the characteristics of DS in Mexican postmenopausal women from a private practice.

Methods

A case-series study was conducted; women of 60 years and older were invited to participate from August to December of 2019, a total of 50 patients were included. Medical history, physical tests, bone densitometry, and body composition analysis were performed; patients who met 3 or more of the following criteria were diagnosed with DS: osteoporosis: T-score ≤ −2.5, falls in a previous year, lean appendicular mass: ≤ 5.45 kg/m2, walking speed: < 1.0 m/s, grip strength: < 20 kg, and body fat percentage: > 40%.

Results

Out of the total 50 patients, 37 were diagnosed with DS, with a prevalence of 74% in our study. Sixteen patients had a history of a non-vertebral fragility fracture, of which 14 had a diagnosis of DS (87%).

Conclusions

DS has a high frequency in our study group, and was found to be closely related to the presence of non-vertebral fragility fractures. More research is needed to describe the prevalence and characteristics of DS with a stronger statistical significance within our population, and among others across the country, to get an extensive understanding of its presentation in Mexican women.

Key Points

• The frequency of DS in this study is higher than the one that is described in global literature.

• DS diagnosis is closely related to the antecedent of non-vertebral fragility fracture.

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Data Availability

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Code availability

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Acknowledgements

We thank Natalia Hernandez-Rodriguez and Jose Maria Espinoza-Espinoza for their support with work related to the densitometry studies. We thank Dr. Thomas Arias-Fernandez and Dr. Armando Martinez-Salazar for comments on the manuscript and assistance with English translation.

Funding

This study was funded by Centro de Investigacion en Artritis y Osteoporosis led by Dr. Francisco Fidencio Cons Molina.

Author information

Authors and Affiliations

  1. Universidad Autonoma de Baja California (Facultad de Medicina Mexicali), Mexicali, Baja California, Mexico

    Karen Burgueno-Aguilar & Marissa Alexandra Gudino-Barroso

  2. Centro de Investigacion en Artritis y Osteoporosis, Mexicali, Baja California, Mexico

    Francisco Fidencio Cons-Molina & Daniela Garcia-Jimenez

  3. Centro de Estudios Universidad Xochicalco, Mexicali, Baja California, Mexico

    Luis Eduardo Bejarano-Lopez

Authors
  1. Karen Burgueno-Aguilar
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  2. Francisco Fidencio Cons-Molina
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  3. Daniela Garcia-Jimenez
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  4. Luis Eduardo Bejarano-Lopez
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  5. Marissa Alexandra Gudino-Barroso
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Corresponding author

Correspondence to Karen Burgueno-Aguilar.

Ethics declarations

Ethics approval

This study was approved by the Investigation and Ethics Committee from the Faculty of Medicine of Universidad Autonoma de Baja California, Mexicali campus. All procedures performed in studies involving human participants were under the ethical standards of the institutional and/or national research committee and the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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All subjects agreed to participate in this study and provided written informed consent.

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Conflicts of interest

Karen Burgueno-Aguilar, Daniela Garcia-Jimenez, Luis Eduardo Bejarano-Lopez, and Marissa Alexandra Gudino-Barroso declare no competing financial interests. Francisco Fidencio Cons-Molina is an Advisory Board assessor for Amgen.

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Burgueno-Aguilar, K., Cons-Molina, F.F., Garcia-Jimenez, D. et al. Dysmobility syndrome: a case-series study describing a musculoskeletal syndrome in postmenopausal Mexican women. Arch Osteoporos 16, 54 (2021). https://doi.org/10.1007/s11657-021-00897-7

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