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Study of Qingre Liyan Decoction (清热利咽汤) in treating and preventing acute radioactive oral mucositis

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Abstract

Objective

To study the effect of Qingre Liyan Decoction (清热利咽汤, QRLYD) in the prevention and treatment of acute radiative oral mucositis (AROM), and to explore the mechanism of QRLYD by detecting epidermal growth factor (EGF) and T lymphocytes (CD3, CD4, and CD8).

Methods

Sixty patients conforming with the standard were randomly assigned to two groups, 30 patients in each group. Patients in the trial group were treated with QRLYD, and those in the control group were treated with Dobell’s solution, both groups receiving conventional radiation treatment. The treatment course for both groups was 6 weeks on average. Blood routine test, CD3, CD4, and CD8 in the peripheral blood and EGF in the saliva were detected one day before and on the 14th and 28th day of radio-therapy.

Results

Patients in the trial group were in good condition with normal spirits and intake of food and drinks. The incidence of AROM is lower and the effect in preventing AROM is higher in the trial group than those in the control group (P<0.05). The EGF in saliva, and CD4 and CD8 in the blood of patients in the trial group were higher than those in the control group (P<0.05).

Conclusion

QRLYD can cure and prevent AROM. The mechanism may be related with its effects in enhancing body immunity and promoting salivary EGF.

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Authors and Affiliations

  1. Department of Integrative Medicine, Shaanxi Province Oncology Hospital, Xi’an, 710061, China

    Wu Min-hui  (吴敏慧), Yuan Bin  (袁 彬), Liu Qiu-fang  (刘秋芳) & Wang Qian  (王 倩)

Authors
  1. Wu Min-hui  (吴敏慧)
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  2. Yuan Bin  (袁 彬)
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  3. Liu Qiu-fang  (刘秋芳)
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  4. Wang Qian  (王 倩)
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Corresponding author

Correspondence to Yuan Bin  (袁 彬).

Additional information

Supported by the Foundation Item of Shaanxi Provincial Administration of Traditional Chinese Medicine (No.0331)

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Wu, Mh., Yuan, B., Liu, Qf. et al. Study of Qingre Liyan Decoction (清热利咽汤) in treating and preventing acute radioactive oral mucositis. Chin. J. Integr. Med. 13, 280–284 (2007). https://doi.org/10.1007/s11655-007-0280-9

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  • DOI: https://doi.org/10.1007/s11655-007-0280-9

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