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Neuroimaging of Langerhans cell histiocytosis: a radiological review

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Abstract

The neuroimaging of Langerhans cell histiocytosis (LCH), in most of the cases, is nonspecific and can vary depending on the location, especially as shown on magnetic resonance imaging (MRI). In the absence of a clinical history of LCH, isolated central nervous system (CNS) lesion presents a diagnostic challenge. LCH should be considered in the differential diagnosis of craniofacial tumors and neurodegenerative (ND) lesions of the brain. MRI is the modality of choice for investigating the CNS-LCH. Long-term follow-up with MRI is indicated in patients with ND-LCH. This retrospective study provides a comprehensive description of the spectrum of neuroimaging findings in patients with LCH, the underlying neuropathology, and follow-up study of the disease.

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References

  1. Rasalkar DD, Tong C, Cheng FWT, Li CK, Paunipagar BK, Chu WCW. An institutional audit and pictorial review of Langerhans’ cell histiocytosis presented with intracranial manifestations. J Hong Kong Coll Radiol. 2010;13:46–51.

    Google Scholar 

  2. Prayer D, Grois N, Prosch H, Gadner H, Barkovich AJ. MR imaging presentation of intracranial disease associated with Langerhans cell histiocytosis. AJNR Am J Neuroradiol. 2004;25:880–91.

    PubMed  Google Scholar 

  3. D’Ambrosio N, Soohoo S, Warshall C, Johnson A, Karimi S. Craniofacial and intracranial manifestations of Langerhans cell histiocytosis: report of findings in 100 patients. AJR Am J Roentgenol. 2008;191:589–97.

    Article  PubMed  Google Scholar 

  4. Steiner M, Prayer D, Asenbaum S, Prosch H, Minkov M, Unger E, et al. Modern imaging methods for the assessment of Langerhans’ cell histiocytosis-associated neurodegenerative syndrome: case report. J Child Neurol. 2005;20:253–7.

    PubMed  Google Scholar 

  5. Ribeiro MJ, Idbaih A, Thomas C, Remy P, Martin-Duverneuil N, Samson Y, et al. 18F-FDG PET in neurodegenerative Langerhans cell histiocytosis: results and potential interest for an early diagnosis of the disease. J Neurol. 2008;255:575–80.

    Article  PubMed  Google Scholar 

  6. Buchmann L, Emami A, Wei JL. Primary head and neck Langerhans cell histiocytosis in children. Otolaryngol Head Neck Surg. 2006;135:312–7.

    Article  PubMed  Google Scholar 

  7. Chen HC, Shen WC, Chou DY, Chiang IP. Langerhans cell histiocytosis of the skull complicated with an epidural hematoma. AJNR Am J Neuroradiol. 2002;23:493–5.

    PubMed  Google Scholar 

  8. Fernández-Latorre F, Menor-Serrano F, Alonso-Charterina S, Arenas-Jiménez J. Langerhans’ cell histiocytosis of the temporal bone in pediatric patients: imaging and follow-up. AJR Am J Roentgenol. 2000;174:217–21.

    Article  PubMed  Google Scholar 

  9. Schmidt S, Eich G, Geoffray A, Hanquinet S, Waibel P, Wolf R, et al. Extraosseous Langerhans cell histiocytosis in children. Radiographics. 2008;28:707–26.

    Article  PubMed  Google Scholar 

  10. Erly WK, Carmody RF, Dryden RM. Orbital histiocytosis X. Am J Neuroradiol. 1995;16:1258–61.

    CAS  PubMed  Google Scholar 

  11. Grois N, Fahrner B, Arceci RJ, Henter J-I, McClain K, Lassmann H, et al. Central nervous system disease in Langerhans cell histiocytosis. J Pediatr. 2010;156:873–81.

    Article  PubMed  Google Scholar 

  12. Leger J, Velasquez A, Garel C, Hassan M, Czernichow P. Thickened pituitary stalk on magnetic resonance imaging in children with central diabetes insipidus. J Clin Endocrinol Metab. 1999;84:1954–60.

    Article  CAS  PubMed  Google Scholar 

  13. Prosch H, Grois N, Wnorowski M, Steine M, Prayer D. Long-term MR imaging course of neurodegenerative Langerhans cell histiocytosis. Am J Neuroradiol. 2007;28:1022–8.

    Article  CAS  PubMed  Google Scholar 

  14. Wnorowski M, Prosch H, Prayer D, Janssen G, Gadner H, Grois N. Pattern and course of neurodegeneration in Langerhans cell histiocytosis. J Pediatr. 2008;153:127–32.

    Article  PubMed  Google Scholar 

  15. Grois N, Prayer D, Prosch H, Lassmann H, CNS LCH Co-operative Group. Neuropathology of CNS disease in Langerhans cell histiocytosis. Brain. 2005;128:829–38.

    Article  PubMed  Google Scholar 

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The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiodiagnosis, Employees’ State Insurance Corporation (ESIC) Model Hospital, Gurgaon, 122001, Haryana, India

    Vikas Chaudhary

  2. Department of Radiodiagnosis, Lady Hardinge Medical College and Associated Hospitals, New Delhi, 110001, India

    Shahina Bano, Rainy Aggarwal, Mahender Kaur Narula, Rama Anand, Ravi Shankar Solanki & Puran Singh

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  1. Vikas Chaudhary
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  2. Shahina Bano
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  3. Rainy Aggarwal
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  4. Mahender Kaur Narula
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  5. Rama Anand
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  6. Ravi Shankar Solanki
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  7. Puran Singh
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Corresponding author

Correspondence to Shahina Bano.

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Chaudhary, V., Bano, S., Aggarwal, R. et al. Neuroimaging of Langerhans cell histiocytosis: a radiological review. Jpn J Radiol 31, 786–796 (2013). https://doi.org/10.1007/s11604-013-0254-0

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  • DOI: https://doi.org/10.1007/s11604-013-0254-0

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