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Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway

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Abstract

Objective

Secoemestrin C (SC), an epitetrathiodioxopiperazine isolated from Aspergillus nidulans, has been previously reported to have immunomodulatory and hepatoprotective effects against acute autoimmune hepatitis. However, the effect of SC on regulating the inflammation and its underlying mechanisms in the pathogenesis of psoriasis remain unclear. This study aimed to evaluate the effects of SC on inflammatory dermatosis both in vitro and in vivo.

Methods

In vitro, HaCaT cells were induced with tumor necrosis factor-alpha (TNF-α, 10 ng/mL) to establish an inflammatory injury model, and the expression of nuclear transcription factor-κB (NF-κB) pathway components was measured using qRT-PCR and Western blotting. An in vivo mouse model of imiquimod (IMQ)-induced psoriasis-like skin inflammation was used to evaluate the effectiveness of SC in alleviating psoriasis.

Results

SC significantly blocked the activation of NF-κB signaling in TNF-α-stimulated HaCaT cells. In addition, systemic and local administration of SC improved psoriatic dermatitis in the IMQ-induced mouse model. SC reduced skin scale and significantly inhibited the secretion of inflammatory factors in skin lesions.

Conclusion

The protective effect of SC against psoriatic-associated inflammation reveals its potential therapeutic value for treating psoriasis.

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Author notes

  1. Both authors contributed equally to this study.

Authors and Affiliations

  1. Department of Stomatology, Chengdu Seventh People’s Hospital, Chengdu, 610044, China

    Zhi-bin Zhu & Meng-jie Liu

  2. Department of Pharmacy, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jing Wang, Zhou Shu & Jie Cao

Authors
  1. Zhi-bin Zhu
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  2. Meng-jie Liu
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  3. Jing Wang
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  4. Zhou Shu
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  5. Jie Cao
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Corresponding author

Correspondence to Jie Cao.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.

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Zhu, Zb., Liu, Mj., Wang, J. et al. Secoemestrin C Ameliorates Psoriasis-like Skin Inflammation in Mice by Suppressing the TNF-α/NF-κB Signaling Pathway. CURR MED SCI 44, 232–240 (2024). https://doi.org/10.1007/s11596-024-2828-8

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  • DOI: https://doi.org/10.1007/s11596-024-2828-8

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