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Validation and Application of the Chinese Version of the M. D. Anderson Symptom Inventory in Breast Cancer Patients

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Abstract

Objective

To validate and use the Chinese Version of the M. D. Anderson Symptom Inventory (MDASI-C) to assess the symptom burden of breast cancer patients in China.

Methods

A total of 342 breast cancer patients in China participated in this study. Their symptoms were investigated with the MDASI-C from November 2020 to February 2021, and the reliability and validity of this tool were evaluated, respectively. Cluster analysis and correlation analysis were also performed.

Results

The Cronbach’s alpha coefficient values of the symptom and interference items were 0.827 and 0.880, respectively. Construct validity revealed a four-factor structure. The Kaiser—Meyer—Olkin value was 0.760. The Karnofsky Performance Status, treatment phase, and cancer stage of the patients were grouped, and the differences of scores within the groups were significant. In addition, the employment status, education level, and age of the patients were significantly correlated with the symptoms. The correlation analysis of the education level of the patients showed that most of the symptoms and interference items were reduced as the education level was increased. The top three symptoms were disturbed sleep (3.10±2.52), difficulty remembering (2.54±2.30), and fatigue (2.24±2.13). The clinical and biochemical indicators such as body mass index and neutral granulocyte lymphocyte ratio had effects on many symptoms. As the patients’ BMI increased, the patients’ pain, disturbed sleep, and difficulty remembering were aggravated, and numbness was alleviated.

Conclusion

The MDASI-C is a reliable and effective assessment tool to evaluate patients with breast cancer in China. The symptoms are related to many clinical and biochemical indicators.

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Authors and Affiliations

  1. Cancer Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Ren-wang Chen, Qiong Wang, Ting Hu, Yu-xiu Xie, Hai-yan Chang & Jing Cheng

Authors
  1. Ren-wang Chen
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  2. Qiong Wang
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  3. Ting Hu
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  4. Yu-xiu Xie
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  5. Hai-yan Chang
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  6. Jing Cheng
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Corresponding author

Correspondence to Jing Cheng.

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The authors declare that they have no conflicts of interest.

Additional information

This work was supported by the National Natural Science Foundation of China (No. 81672977).

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Chen, Rw., Wang, Q., Hu, T. et al. Validation and Application of the Chinese Version of the M. D. Anderson Symptom Inventory in Breast Cancer Patients. CURR MED SCI 42, 426–433 (2022). https://doi.org/10.1007/s11596-022-2544-1

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  • DOI: https://doi.org/10.1007/s11596-022-2544-1

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