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Identification of BTG1 Status in Solid Cancer for Future Researches Using a System Review and Meta-analysis

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Summary

Abundant studies have been conducted to identify how B-cell translocation gene 1 protein (BTG1) gene affects the differentiation, proliferation, metastasis of cancer cells, and how it further regulates the generation or development of diseases to influence the prognosis of patients. However, the data from single research were not powerful enough. The correlations between BTG1 expression and mechanisms of tumorigenesis or prognosis of patients are still in controversial. Our system review and meta-analysis provided a complete explanation about the association between BTG1 expression and clinicopathological features or prognosis of patients, which further laid a foundation for future research on BTG1. Fifteen eligible studies consisting of 1992 participants were included. We uncovered that BTG1 expression in solid tumors was associated with lymph node status (RR=0.66, 95% CI: 0.58–0.75, P=0.142), TMN stage status (RR=2.13, 95% CI: 1.71–2.65, P=0.001), T category (RR=1.90, 95% CI: 1.20–3.00, P=0.000), histological differentiation (RR=1.91, 95% CI: 1.55–2.37, P=0.012), vascular invasion (RR=0.90, 95% CI: 0.57–1.41, P=0.001). BTG1 low expression was significantly associated with overall survival (OS) (HR=0.47, 95% CI: 0.38–0.67, P=0.000). It concluded that BTG1 possessed the potential value for future research and could be recommended as a significant biomarker in solid tumor.

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Authors and Affiliations

  1. Cancer Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xiu-qiong Chen, Hua Xiong, Ya-li Wang, Wen-hua Tang & Yan-mei Zou

  2. Tianjin Medical University, Tianjin, 300203, China

    Fan-qiao Meng

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  1. Xiu-qiong Chen
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  2. Fan-qiao Meng
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  3. Hua Xiong
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  4. Ya-li Wang
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  5. Wen-hua Tang
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Correspondence to Yan-mei Zou.

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Conflict of Interest Statement

All authors have no conflicts of interest in our research.

This work was supported by Natural Science Foundation of Hubei Province of China (No. 2018CFB611).

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Chen, Xq., Meng, Fq., Xiong, H. et al. Identification of BTG1 Status in Solid Cancer for Future Researches Using a System Review and Meta-analysis. CURR MED SCI 40, 85–94 (2020). https://doi.org/10.1007/s11596-020-2150-z

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  • DOI: https://doi.org/10.1007/s11596-020-2150-z

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